Negative pressure wound therapy in the treatment of ulcerated infantile haemangioma

Fox, Carly M; Johnson, Bethan; Storey, Kristen; Gupta, Romi Das; Kimble, Roy M.

doi:10.1007/s00383-015-3716-x

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…These therapies have little supporting evidence. Fox et al 30 treated 6 cases of ulcerated hemangioma with the combination of propranolol and negative pressure wound therapy.…”

Section: Resultsmentioning

confidence: 99%

“…When the search was repeated for studies published between January and July 2016, we retrieved 516 additional results. Following title and abstract screening, we selected 138 studies for full-text review and ultimately included 78 studies in our analysis 1-4,7…”

Section: Resultsmentioning

confidence: 99%

“…More interestingly, amongst all of the patients in our analysis, 21 failed oral steroids, 2,8,9,11,18-26 3 failed intralesional steroids, 19 and 7 failed topical steroids. 9,22,27-30 Steroid therapy often produced lesion shrinkage but failed to produce ulcer healing. All 31 were subsequently treated successfully with other therapies.…”

Section: Resultsmentioning

confidence: 99%

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Medical, Surgical, and Wound Care Management of Ulcerated Infantile Hemangiomas: A Systematic Review

et al. 2018

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Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Seventy-seven studies met our inclusion criteria. One study was a randomized controlled trial, 30 were observational studies, and 46 were case reports or case series. There is significant heterogeneity among the methods used. We reviewed 1239 patients in total. Of the 197 treated with oral propranolol, 191 (97.0%) achieved complete ulcer healing. Thirty-one patients failed corticosteroid therapy (oral, intralesional, or topical) and were subsequently successfully treated with other therapies. Surgical resections were typically performed for larger hemangiomas and those causing complications. None of the therapies discussed appear to offer significant advantages over others. Therefore, treatment decisions should be individualized based on location of disease, extent, symptoms, feasibility, cost, and parental preference.

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“…These therapies have little supporting evidence. Fox et al 30 treated 6 cases of ulcerated hemangioma with the combination of propranolol and negative pressure wound therapy.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Medical, Surgical, and Wound Care Management of Ulcerated Infantile Hemangiomas: A Systematic Review

et al. 2018

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“…Since then, NPWT has become widely accepted in the world of wound management, particularly in the context of diabetic ulcers [68], open abdomens [69, 70], sternal wounds [71], open fractures [72] and haemangiomas [73]. Although the exact mechanism of action of NPWT is not yet fully understood, it is known to exert several effects on the local tissue environment.…”

Section: Introductionmentioning

confidence: 99%

Study of negative pressure wound therapy as an adjunct treatment for acute burns in children (SONATA in C): protocol for a randomised controlled trial

Frear

Griffin

Cuttle

et al. 2019

Trials

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Background Although negative pressure wound therapy (NPWT) is widely used in the management of several wound types, its efficacy as a primary therapy for acute burns has not yet been adequately investigated, with research in the paediatric population particularly lacking. There is limited evidence, however, that NPWT might benefit children with burns, amongst whom scar formation, wound progression and pain continue to present major management challenges. The purpose of this trial is to determine whether NPWT in conjunction with standard therapy accelerates healing, reduces wound progression and decreases pain more effectively than standard treatment alone. Methods/design A total of 104 children will be recruited for this trial. To be eligible, candidates must be under 17 years of age and present to the participating children’s hospital within 7 days of their injury with a thermal burn covering <5% of their total body surface area. Facial and trivial burns will be excluded. Following a randomised controlled parallel design, participants will be allocated to either an active control or intervention group. The former will receive standard therapy consisting of Acticoat™ and Mepitel™. The intervention arm will be treated with silver-impregnated dressings in addition to NPWT via the RENASYS TOUCH™ vacuum pump. Participants’ dressings will be changed every 3 to 5 days until their wounds are fully re-epithelialised. Time to re-epithelialisation will be studied as the primary outcome. Secondary outcomes will include pain, pruritus, wound progression, health-care-resource use (and costs), ease of management, treatment satisfaction and adverse events. Wound fluid collected during NPWT will also be analysed to generate a proteomic profile of the burn microenvironment. Discussion The study will be the first randomised controlled trial to explore the clinical effects of NPWT on paediatric burns, with the aim of determining whether the therapy warrants implementation as an adjunct to standard burns management. Trial registration Australian New Zealand Clinical Trials Registry, ACTRN12618000256279 . Registered on 16 February 2018. Electronic supplementary material The online version of this article (10.1186/s13063-019-3223-9) contains supplementary material, which is available to authorized users.

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Aplicación de la terapia de presión negativa en heridas complejas en pediatría

Sánchez

Muñoz-Miguelsanz

2016

Enfermería Clínica

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Negative pressure wound therapy in the treatment of ulcerated infantile haemangioma

Cited by 7 publications

References 24 publications

Medical, Surgical, and Wound Care Management of Ulcerated Infantile Hemangiomas: A Systematic Review

Medical, Surgical, and Wound Care Management of Ulcerated Infantile Hemangiomas: A Systematic Review

Study of negative pressure wound therapy as an adjunct treatment for acute burns in children (SONATA in C): protocol for a randomised controlled trial

Aplicación de la terapia de presión negativa en heridas complejas en pediatría

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