Negative regulation of glucose uptake by Costus pictus in L6 myotube cell line

Pareek, Anil; Suthar, Manish; Godavarthi, Ashok; Goyal, Manoj; Bansal, V. K.

doi:10.4103/0976-9234.68872

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…[8][9][10] Effect of C. pictus on glucose uptake by L6 myotube cell line (skeletal muscle) has also been reported. [18] However, to the best of our knowledge, this is the fi rst report on the cytotoxic activity of C. pictus on any cancer cell line.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the anticancer potential of Costus pictus on fibrosarcoma (HT-1080) cell line

Nadumane¹,

Rajashekar²,

Narayana³

et al. 2011

J Nat Pharm

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Introduction:The present study is aimed at evaluating the anti-proliferative and apoptotic potential of Costus pictus D. Don on fi brosarcoma HT-1080 cell line, and also evaluating its safety to normal human lymphocytes. Materials and Methods: Dried leaves of C. pictus plant were used for aqueous and alcohol extraction. Different concentrations of these were evaluated for their cytotoxicity by trypan blue dye exclusion method and 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT) assay on the cancer cell line (fi brosarcoma HT-1080) and a normal cell line (human peripheral lymphocytes). The apoptotic potential was analyzed by DNA fragmentation analysis of the treated cells. Results: The ethanol extract of C. pictus was found to be anti-proliferative and cytotoxic at lower concentrations and induced cell death in HT-1080 fi brosarcoma cells. The ethanol extract at the same concentrations had no cytotoxicity on normal lymphocytes. Compared to ethanol extracts, aqueous and methanol extracts were less effective. Conclusion: The present investigation, for the fi rst time, reveals the anticancer potential of ethanol extract of C. pictus on HT-1080 cells. It is very likely that the result can be extrapolated to animal or human system. The extract can be used for further purifi cation of the active component for future applications.

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Section: Discussionmentioning

confidence: 96%

Evaluation of the anticancer potential of Costus pictus on fibrosarcoma (HT-1080) cell line

Nadumane¹,

Rajashekar²,

Narayana³

et al. 2011

J Nat Pharm

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“…Though these plants are not approved by the Department of Health (DOH) for herbal medication, various pharmacological activities are attributed under this genus such as hepatoprotective, antioxidant, antibacterial and antifungal activity and most common for its antidiabetic activity 6 . Researches on hypoglycemic effectiveness usually used Costus such as Insulin Plant (C. igneus and C. pictus) [7][8][9] and Crepe Ginger (C. speciosus) 6 and really showed significant results worth for a preclinical trial.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study

Magtulis

Itable

2020

UIP HEATH MED

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Objective: Diabetes Mellitus is a leading illness to the society and despite of a lot of researches, not a single cure has been discovered. Most of the time, people focused on fighting diabetes and medicinal plants were utilized. The purpose of this study was to investigate the hypoglycemic effect of Scarlet Spiral Flag (Costus woodsonii) and to be reviewed for preclinical trials.Methods: 20 male Swiss mice were made diabetic by inducing Alloxan monohydrate. Then separated randomly into 4 groups with different treatments administered daily for 7 days; Control, Positive Control (600 µg/kg Glibenclamide), T1 (250mg/kg Scarlet Spiral Flag ethanolic extract) and T2 (500mg/kg Scarlet Spiral Flag ethanolic extract). Their blood sugar was monitored onset after 1st treatment (6th, 12th and 24th hours) and during the week within the 1st, 4th and 8th day.Results: Both the onset and fasting blood sugar monitoring showed a significant decrease in the mean average blood glucose level of the mice.Conclusion: The ethanolic extract of Scarlet Spiral Flag (Costus woodsonii) has a potent antidiabetic effect in Alloxan-induced diabetic mice. Since it is under the same Genus of the Insulin plant, it has a common effect in terms of lowering the blood glucose level.Keywords: Acclimatization, Alloxan, Costus woodsonii, Ethanolic Extract, Oral Gavage

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“…However, an in vitro study of ethanolic extract of C. pictus leaf was analyzed to study GLUT4 translocation and glucose uptake activity, which showed no direct peripheral action at 300 μg/ml dose comparable with insulin and metformin. [ 32 ] A study evaluated the ability of a tea made from the leaves of C. spicatus to alter glucose homeostasis in C57BLKS/J (KS) db / db mice, a model of obesity-induced hyperglycemia, with progressive beta-cell depletion. Intraperitoneal (IP) insulin tolerance testing after the 10-week study period showed that C. spicatus tea consumption did not alter insulin sensitivity, which suggested that at the dose given, tea made from C. spicatus leaves had no efficacy in the treatment of obesity-induced hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

A review on Insulin plant (Costus igneus Nak)

Hegde

Rao

2014

Phcog Rev

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Costus igneus Nak and Costus pictus D. Don, commonly known as Spiral flag, is a member of Costaceae and a newly introduced plant in India from South and Central America. It is a perennial, upright, spreading plant reaching about two feet tall, with spirally arranged leaves and attractive flowers. In southern India, it usually grows as an ornamental plant and its leaves are used as a dietary supplement in the treatment of diabetes mellitus. Recently, a number of researches have been carried out to evaluate the anti-diabetic potential of this plant. Besides, it has been proven to possess various pharmacological activities like hypolipidemic, diuretic, antioxidant, anti-microbial, anti-cancerous. Further, various phytochemical investigations reveal the presence of carbohydrates, triterpenoids, proteins, alkaloids, tannins, saponins, flavonoids, steroid, and appreciable amounts of trace elements. This work is an attempt to compile and explore the different pharmacological and phytochemical studies reported till date.

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Negative regulation of glucose uptake by Costus pictus in L6 myotube cell line

Cited by 9 publications

References 5 publications

Evaluation of the anticancer potential of Costus pictus on fibrosarcoma (HT-1080) cell line

Evaluation of the anticancer potential of Costus pictus on fibrosarcoma (HT-1080) cell line

Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study

A review on Insulin plant (Costus igneus Nak)

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