Negatively charged cyclodextrins: Synthesis and applications in chiral analysis-A review

Multicharged cyclodextrin supramolecular assemblies

“…Although the literature contains numerous reviews covering the diverse applications of CDs and CD-based assemblies, including metal complexation, 11,41,161,162 cyclodextrin metal–organic frameworks, 163 cyclodextrin covalent organic frameworks, 164–167 supramolecular catalysis and synthesis, 168–170 multistimuli-responsive materials, 15,171–173 polymer materials, 13,24,174–181 self-healing materials, 182 amphiphilic materials, 90,183 crystalline organic materials, 184 liquid crystal materials, 14 rotaxanes/polypseudorotaxanes/catenanes/polyrotaxanes, 185–190 drug/protein/gene delivery, 16,19,23,191–194 molecular recognition and imaging, 1,195–199 molecular machines, 200 thiolated cyclodextrins, 201 cyclodextrin–porphyrinoid systems, 202 foods and antioxidants, 203,204 electrochemical analysis, 5 and chiral analysis, 205 to the best of our knowledge, multicharged CDs as an important building block have not been comprehensively reviewed. Multilevel supramolecular assembly based on electrostatic interactions between opposite charges, including parent CDs modified with multiple charges or encapsulating charged guest molecules, has enabled the construction of a diverse variety of multifunctional materials, and these have been widely applied in drug delivery, 206–214 bioimaging, 215–218 molecular recognition, 219–231 nanochannels, 232,233 molecular switches, 26,234 adsorbents and enrichment, 235–237 surfactants, 238 electrospinning supramolecular systems, 239,240 supercapacitors, 241 CD–polyoxometalate complexes, 242–245 liquid crystal materials, 246 multistimuli-responsive materials, 247–252 pseudorotaxanes, 253 conductive polymers, 254 photodynamic/chemotherapy, 255 molecular shuttles, 256,257 etc.…”

Chiral Capillary Electrokinetic Chromatography: Principle and Applications, Detection and Identification, Design of Experiment, and Exploration of Chiral Recognition Using Molecular Modeling

“…Negatively charged CDs (anionic CDs) are also especially important and widely applied for the enantioseparation of positively charged cationic compounds (basic chiral compounds) and neutral chiral compounds [ 56 ].…”

Cyclodextrins in the antiviral therapy

“…The vast majority of these publications concern drug analysis, especially chiral separations. CDs are not only excellent chiral selectors but also have successful positional isomer-selector properties [41][42][43]. Due to its low reagent requirements, flexibility, and sensitivity, capillary electrophoresis (CE) is increasingly paving the way for analytical applications of CDs in pharmaceutical analyses.…”