Neglected Tropical Diseases and Sudden Cardiac Death: The NET-Heart Project

Abstract

Sudden cardiac death (SCD) is responsible for approximately 6% of global mortality and 25% of cardiovascular (CV) deaths. SCD has been traditionally linked to coronary artery disease, valvular heart disease, cardiomyopathies, and genetic arrhythmia disorders. However, advancements in care for these diseases have not translated to a proportional reduction in SCD. This suggests an important role of underrecognized contributing pathologies. Neglected tropical diseases (NTDs) are a group of illnesses prevalent in tropical and sub-tropical regions which have been understudied partially due to their high prevalence in marginalized populations. The relationship between SCD and Chagas disease has been well-established, though emerging literature suggests that other NTDs with CV involvement may lead to fatal arrhythmias. Additionally, specific therapies for a subset of NTDs put patients at increased risk of malignant arrhythmias and other cardiac complications. This review aims to summarize the association between a group of selected NTDs and SCD.

Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational Models

“…Sudden death is highlighted as a conspicuous feature (60%) in carriers of Chagas disease [ 8 ]. It is noteworthy that antiarrhythmic drugs effectively reduce ventricular arrhythmias but are not successful in reducing mortality [ 9 , 10 ]. Prevention of transmission, expansion of diagnostic testing, and access to treatment and clinical care remain important for the management of the disease [ 11 ].…”