Neglected tropical diseases in Australia: a narrative review

Kurcheid, Johanna; Gordon, Catherine A.; Clarke, Naomi E.; Wangdi, Kinley; Kelly, Matthew; Lal, Aparna; Mutombo, Polydor Ngoy; Wang, Dongxu; Mationg, Mary Lorraine; Clements, Archie C. A.; Muhi, Stephen; Bradbury, Richard S.; Biggs, Beverley‐Ann; Page, Wendy; Williams, Gail; McManus, Donald P.; Gray, Darren J.

doi:10.5694/mja2.51533

Cited by 4 publications

(2 citation statements)

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“…Symptoms appear on the skin and subcutaneous tissue, with the formation of nodules, plaques, oedemas and skin ulcerations [15]. However, treatment may be delayed due to the often painless progression of the lesions [15,16]. This delay may result in disability surrounding joint movements or severe deformity [17].…”

Section: Introductionmentioning

confidence: 99%

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Multi-epitope vaccine candidates based on mycobacterial membrane protein large (MmpL) proteins against Mycobacterium ulcerans

Ishwarlall,

Adeleke,

Maharaj

et al. 2023

Open Biol.

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Buruli ulcer (BU) is a neglected tropical disease. It is caused by the bacterium Mycobacterium ulcerans and is characterized by skin lesions. Several studies were performed testing the Bacillus Calmette-Guérin (BCG) vaccine in human and animal models and M. ulcerans- specific vaccines in animal models. However, there are currently no clinically accepted vaccines to prevent M. ulcerans infection. The aim of this study was to identify T-cell and B-cell epitopes from the mycobacterial membrane protein large (MmpL) proteins of M. ulcerans. These epitopes were analysed for properties including antigenicity, immunogenicity, non-allergenicity, non-toxicity, population coverage and the potential to induce cytokines. The final 8 CD8 + , 12 CD4 + T-cell and 5 B-cell epitopes were antigenic, non-allergenic and non-toxic. The estimated global population coverage of the CD8 + and CD4 + epitopes was 97.71%. These epitopes were used to construct five multi-epitope vaccine constructs with different adjuvants and linker combinations. The constructs underwent further structural analyses and refinement. The constructs were then docked with Toll-like receptors. Three of the successfully docked complexes were structurally analysed. Two of the docked complexes successfully underwent molecular dynamics simulations (MDS) and post-MDS analysis. The complexes generated were found to be stable. However, experimental validation of the complexes is required.

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Section: Introductionmentioning

confidence: 99%

“…The causative agent of the neglected tropical disease Buruli ulcer (BU) is Mycobacterium ulcerans [14]. Symptoms appear on the skin and subcutaneous tissue, with the formation of nodules, plaques, oedemas and skin ulcerations [15]. However, treatment may be delayed due to the often painless progression of the lesions [15,16].…”

Section: Introductionmentioning

confidence: 99%