2019
DOI: 10.1001/jama.2019.17576
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Neglecting Major Health Problems and Broadcasting Minor, Uncertain Issues in Lifestyle Science

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Cited by 27 publications
(23 citation statements)
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“…Second, we tested the implications of differential reliability for association testing by analyzing results of epigenome-wide association studies of tobacco smoking, one of the most harmful health risks in the modern world. 19 Third, we tested the implications of differential reliability for epigenetic biomarker development by analyzing multi-probe-algorithm-based measurements that are intended to capture information about aging (i.e., “DNA methylation clocks”). Finally, we tested the implications of differential reliability in ascribing biological function to DNA methylation by assessing the impact of reliability on (1) correlations between DNA methylation and gene expression and on (2) correlations between levels of DNA methylation measured in blood tissue and brain tissue.…”
Section: Introductionmentioning
confidence: 99%
“…Second, we tested the implications of differential reliability for association testing by analyzing results of epigenome-wide association studies of tobacco smoking, one of the most harmful health risks in the modern world. 19 Third, we tested the implications of differential reliability for epigenetic biomarker development by analyzing multi-probe-algorithm-based measurements that are intended to capture information about aging (i.e., “DNA methylation clocks”). Finally, we tested the implications of differential reliability in ascribing biological function to DNA methylation by assessing the impact of reliability on (1) correlations between DNA methylation and gene expression and on (2) correlations between levels of DNA methylation measured in blood tissue and brain tissue.…”
Section: Introductionmentioning
confidence: 99%
“…Neste processo, o spin pode ocorrer de forma até inconsciente pelos próprios cientistas no momento de escrever e argumentar os seus achados, podendo ser não intencional em sua natureza 20 . Ele pode ocorrer de forma tão inconsciente que os estudos que quantificaram a presença de spin em outros estudos também foram passíveis de spin 22 . O fato deste presente texto científico sobre spin apresentar uma possível fragilidade metodológica nos estudos científicos que estudam spin reflete o fato de que a ciência deve ser escrita de uma forma que contemple os dois (ou mais) lados/aspectos de uma investigação.…”
Section: O Que é Spin?unclassified
“…Um número crescente de cientistas acredita que tais critérios estão desalinhados das necessidades da sociedade e desconectados das evidências, podendo, dessa forma, ter boa parcela de culpa pela possível crise de reprodutibilidade da ciência, falta de transparência e baixa qualidade de um grande contingente de publicações científicas 19 . Neste contexto, é comum, por exemplo, que a população leiga fique confusa com manchetes de revistas acerca de resultados de pesquisas que se contradizem a todo o momento, sendo que este fenômeno pode afetar negativamente a confiança do público na ciência 20 .…”
Section: "Publish or Perish" E O Desperdício Evitável Em Pesquisaunclassified