Neither male age nor semen parameters influence clinical pregnancy or live birth outcomes from IVF

Mariappen, Uma; Keane, Kevin N.; Hinchliffe, Peter M; Dhaliwal, Satvinder S.; Yovich, John L.

doi:10.1016/j.repbio.2018.11.003

Cited by 25 publications

(45 citation statements)

References 32 publications

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“…This finding may also be associated with the finding that ICSI without spermatozoa selection cannot improve the clinical outcomes for the patients with teratozoospermia (Li et al, 2016). A retrospective cohort study reported that sperm morphology (NSMR ≥4%) did not significantly affect the clinical pregnancy or live‐birth outcomes of IVF cycles (Mariappen, Keane, Hinchliffe, Dhaliwal, & Yovich, 2018). However, regardless of whether the NSMR was ≥4% or <4%, our retrospective study showed that NSMR did not affect the clinical pregnancy or live‐birth outcomes in c‐IVF cycles (Table 2 and 4).…”

Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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The present study assessed the influences of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional in vitro fertilisation cycles. This retrospective study analysed 427 and 2,728 cycles from the normal sperm morphology rate <4% and ≥4% group respectively. The clinical (total fertilisation failure, clinical pregnancy, implantation and abortion) and neonatal (sex, gestational age, preterm birth, birthweight, low birth weight, live births and birth defects of newborns) outcomes were compared. The rate of total fertilisation failure in the normal sperm morphology rate <4% group was significantly higher compared with that in the normal sperm morphology rate ≥4% group (2.8% versus 1.2%, p = .012). Total fertilisation failure was completely resolved by early rescue intracytoplasmic sperm injection. The clinical pregnancy, implantation and abortion rates were not significantly different between the two groups. Additionally, the sex, preterm birth, low birth weight, live births and birth defect rates, gestational age and birthweight of newborns were not significantly different between the two groups. Thus, normal sperm morphology rate <4% significantly increased the total fertilisation failure rate but did not affect the clinical or neonatal outcomes.

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Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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“…Due to the complexity of reproductive process, it is difficult to associate a single semen maker with pregnancy outcome. Conflicting evidence regarding the association between male factors and ART outcomes was not only observed in studied using semen parameters as male fertility markers (Bartolacci et al 2018;Borges et al 2016;Capelouto et al 2018;Chapuis et al 2017;Mariappen et al 2018;Mazzilli et al 2017), but also in those using other male fertility biomarkers, such as DNA fragmentation (Colaco & Sakkas 2018). While many of the previous analyses were univariate in nature, the conflicting results may imply the importance of Manuscript to be reviewed response, maternal age and endometrial thickness may play significant roles (McLernon et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…While many of the previous analyses were univariate in nature, the conflicting results may imply the importance of Manuscript to be reviewed response, maternal age and endometrial thickness may play significant roles (McLernon et al 2016). In their study investigating the effects of male factor on ART outcomes, Mariappen et al found that female age but not male age or semen parameters has significant influence on pregnancy or live birth (Mariappen et al 2018). In our study, the association between male fertility and IVF outcomes is strengthened by a prospective cohort in which female counterparts with good prognosis were selected and important covariates for IVF outcomes were considered.…”

Section: Discussionmentioning

confidence: 99%

“…The semen parameters, however, may only have limited predicting value for clinic outcomes among IVF patients.Bartolacci et al suggested that oligozoospermia according to WHO criteria may affect the embryo development but not top quality blastocyst formation rate or the establishment of pregnancy in ICSI cycles(Bartolacci et al 2018). In a study including 1280 IVF cycles, Mariappen et al suggested that the semen parameters have an insignificant role to play in embryo quality and overall outcomes(Mariappen et al 2018). Similarly, Capelouto et al found a lack of association between semen parameters and live birth rate in frozen donor oocyte cycles…”

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confidence: 99%

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Peer Review #1 of "Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles (v0.2)"

Yoshida¹

2019

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The prospective study including 166 participants aims to evaluate the association between seminal prosaposin and the outcomes of in vitro fertilization (IVF) cycles in humans. Generalized linear model (GLM) was used to analyze the associations between seminal prosaposin concentrations and normal fertilization rates and good embryos proportion. Generalized estimating equation (GEE) was used to evaluate the association between embryo parameters and the prosaposin concentrations. Each model was adjusted for age of the couples, female basal FSH, AFC and BMI, starting dose and oocyte yield of IVF cycles and smoker. GLM models suggested that prosaposin was significantly associated with fertilization rate (P=0.005) and good embryo proportion (P=0.038) while none of the semen parameters (sperm concentration, motility, progressive motility, normal morphology rate, postwash sperm concentration and motility) was significantly associated with the parameters in the cohort. Using GEE, it is also shown that prosaposin was positively associated with the occurrence of early cleavage and negatively associated with uneven cleavage pattern on day 3. In both the overall population and the normozoospermia patients, the prosaposin was significantly associated with pregnancy with adjustment with covariates. In conclusion, our data suggested that seminal prosaposin concentration could provide more information regarding normal fertilization and embryo development in IVF than traditional semen parameters.

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“…In fact, no increase in the frequency of health problems caused by genomic imprinting abnormalities, such as Beckwith-Wiedemann, Prader-Willi, and Angelman syndromes, has been detected in children born after ICSI with testicular spermatozoa [91] and ROSI [59]. A recent study [92] has suggested that the supposed increase of imprinting errors, present in the sperm of infertile patients, does not have an obvious influence on assisted reproduction outcome or the imprinting of offspring, probably because the imprinting errors in sperm are selectively discarded or corrected during development [20,93].…”

Section: Current Clinical Experiencementioning

confidence: 99%

Paternal Effects on Embryonic, Fetal and Offspring Health: The Role of Epigenetics in the ICSI and ROSI Era

Tesarik

2020

Innovations in Assisted Reproduction Technology

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Paternal effects on the developmental potential of human embryos have been studied since the early 1990s, particularly with respect to newly emerging assisted reproduction technologies. Both genetic and epigenetic paternal effects can influence postfertilization development and cause implantation failure or miscarriage. However, it is only over the last few years that issues related to paternal effects associated with different assisted reproduction techniques on the health status of newborn and adult progeny have been focused. At the same time, new findings point out different, yet unexplored, areas of research into the potentially responsible factors, including the activity of the sperm-derived oocyte-activating factor and the oocyte signaling pathways mediating its action, the methylation status of both imprinted and non-imprinted genes, correct replacement of sperm nuclear protamines with oocyte-derived histones, the histone acetylation status, and the function of sperm-borne small RNAs. It is increasingly important to know how these developmentally important epigenetic regulators can be altered in the context of the current micromanipulation-assisted fertilization techniques, intracytoplasmic sperm injection (ICSI) and round spermatid injection (ROSI). Last but not least, transgenerational transmission of acquired, environmentally conditioned disorders from fathers to offspring is a newly emerging issue which warrants further research.

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Neither male age nor semen parameters influence clinical pregnancy or live birth outcomes from IVF

Cited by 25 publications

References 32 publications

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Peer Review #1 of "Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles (v0.2)"

Paternal Effects on Embryonic, Fetal and Offspring Health: The Role of Epigenetics in the ICSI and ROSI Era

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