Nematicidal activity of essential oils of medicinal plants

Boyko, О. О.; Brygadyrenko, V. V.

doi:10.2478/foecol-2021-0005

Cited by 18 publications

(8 citation statements)

References 41 publications

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“…While in eggs there were other oils such as mallow (Pelargonium graveolens), star anise (Illicium verum), Lawson's cypress (Chamaecyparis lawsoniana) and coriander (Coriandrum sativum) that had ovicidal action with lethal doses of less than 5 mg/mL.In another study, the use of Mallow (Pelargonium graveolens) did not show larvae mortality of Strongyloides papillosus and H. contortus from sheep in Ukraine. Although, high larval mortality was found with Cinnamomum verum and Syzygium aromaticum (100%)(Boyko and Brygadyrenko 2021). In the present study, C. verum also had high egg mortality, which corroborates the possibility of using this product for the control of cyathostomin eggs and larvae.…”

supporting

confidence: 83%

Preliminary screening of plant essential oils from an oceanic climate zone (NW Spain) for the control of equine cyathostomins

Garduño,

Vázquez,

Monteiro

et al. 2023

Preprint

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Cyathostomins are gastrointestinal nematodes (GIN) that affect equines in many parts of the world. Due to anthelmintic resistance (AR), it is necessary to search for control alternatives. The objective of the study was to carry out a screening of 26 essential oils (EOs) from plants to determine in vitro their action on cyathostomins. Essential oils were obtained by hydro-distillation from leaves, flowers, fruits and seeds of the selected species and used against the eggs of cyathostomins by means of the tests of egg hatching and larval motility inhibition. For each EO, different concentrations were prepared (250, 125, 62.5, 31.3, 15.6, 7.8, 3.9, 2.0, 1.0, 0.5 and 0.24 mg/mL). Oxfendazole at 2.5% mixed with closantel 5% was used as positive control, and PBS served as negative control. Cyathostomin eggs were obtained from feces of infected horses and infective larvae were recovered after de coproculture. The in vitro test was carried out 36 hours after the challenge con the EOs. The highest production of EOs was obtained from leaves of bay, eucalyptus, mallow and basil, as well as from seeds of black pepper, coriander, cinnamon, anise, and peel of orange and cloves, cumin and Lawson’s cypress. The oils extracted from laurel leaves, ground cinnamon, anise, cumin, and coriander seeds had a very high effect on cyathostomins eggs up to doses lower than 3.9 mg/mL. Therefore, in addition to the uses in other species such as fungi and bacteria, the use of EOs in the control of nematode eggs gives greater importance as alternative control.

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supporting

confidence: 83%

Preliminary screening of plant essential oils from an oceanic climate zone (NW Spain) for the control of equine cyathostomins

Garduño,

Vázquez,

Monteiro

et al. 2023

Preprint

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“…Also, in our previous studies, we determined that aqueous tincture of V. angus-castus in in vitro experiment had weak lethal effect on larvae of parasitic intestinal nematodes of Strongyloides papillosus (Wedl, 1856), though mortality of nematodes of Haemonchus contortus (Rudolphi, 1803) in aqueous tincture of this plants was no different from the control (Boyko et al, 2020). Essential oil from L. officinalis had similar effect on these species of nematodes, causing 4-fold increase in mortality of larvae of S. papillosus, but took no effect on larvae of H. contortus (Boyko & Brygadyrenko, 2021). Thus, possible effect of medicinal plants of Lamiaceae family may likely occur through various species of parasitic nema-todes of Strongyloides genus, specific various species of model animals and human.…”

Section: Discussionmentioning

confidence: 98%

Influence of Lavandula angustifolia, Melissa officinalis and Vitex angus-castus on the organism of rats fed with excessive fat-containing diet

Lieshchova

Brygadyrenko

2021

Regul. Mech. Biosyst.

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Plant food additives are becoming more and more popular and broadly applied products, though the information on risks they poses to the organism is limited and contradictive. Obesity and overeating are some of the commonest health issues around the world, and people are increasingly consuming workability-enhancing preparations as a simple and fast method of weight control. The plant-based preparations are considered less harmful than the synthetic chemical ones. Lavandula angustifolia Mill., Melissa officinalis L. and Vitex angus-castus L. are broadly used as food additives and medicinal plants, despite the fact that their complex physiological assessment on model animals in the conditions of obesity has not yet been performed. We carried out a 30-day experiment on white male rats. All the animals were given high-fat diet, and the experimental animals, in addition to this diet, received 5% crumbled dry herbs of L. angustifolia, M. officinalis or V. angus-castus. Taking into account the overall amount of consumed food, the mean daily gain in body weight; at the end of the experiment, we determined the index of the weight of the internal organs, biochemical and morphological blood parameters. At the beginning and the end of the experiment, the rats were examined for motor and orienting activities, and emotional status. Rats on high-fat diet gained up to 112% body weight by the end of the experiment, while rats that had received V. angus-castus gained up to 119%, M. officinalis – 135%, L. angustifolia – 139%, compared with the initial body weight. Addition of medicinal plants to the diet led to increase in average daily weight increment, significantly and reliably after consuming lavender and lemon balm, less significantly and unreliably after eating Vitex. L. angustifolia and M. officinalis reduced the relative brain weight, and ingestion of L. angustifolia and M. officinalis caused notable decrease in the relative mass of the thymus (down to 58% and 47% of the relative weight of thymus in animals of the control group respectively). Also, these plants decreased the motor and orienting activities of the rats by the end of the experiment. As for the biochemical parameters of blood, the activity of alkaline phosphatase significantly increased to 406% following consumption of Melissa, to 350% after consuming lavender, and to 406% after Vitex, compared to the control group. Furthermore, all the groups were observed to have increased AST and ALT activities. Intake of lavender led to increases in cholesterol (to 125%) and LDL cholesterol (to 228%), whereas the groups that consumed lemon balm were observed to have decreases in urea nitrogen (to 79%), totalbilirubin (to 63%) and triglycerides (to 63%). Addition of Vitex led to increase in the index of aterogenecity against the background of notable fall in HDL cholesterol (to 52% of the control group). The medicinal plants also contributed to the normalization of the glucose level. Morphological analysis of blood revealed no significant changes, except heightened content of monocytes in blood, which is characteristic of all groups, including the control. Effects of L. angustifolia, M. officinalis and V. angus-castus on the organism of rats on excessive-fat diet require additional histological, histochemical and immunological surveys.

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“…The antihelmintic activity of certain bioactive principles (triterpenoid saponins, glycosides of oleanic acid) isolated from marigold, against free-living stages of Heligmosomoides bakery and Heligmosomoides polygyrus was already reported on [ 63 , 64 ]. The essential oil of C. officinalis killed L1-2 larvae of Strongiloides papillosus but had no effect on the embryogenesis of A. suum eggs [ 65 ]. In the present study, the ethanolic marigold extract displayed the strongest anticoccidial activity, compared to the other plants studied.…”

Section: Discussionmentioning

confidence: 99%

The In Vitro Anticoccidial Activity of Some Herbal Extracts against Eimeria spp. Oocysts Isolated from Piglets

et al. 2023

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Coccidiosis in pigs seldom results in important economic losses. However, it can influence growth rates in weaners and it is an important hygiene indicator in swine farms. Certain herbs, along with their extracts, have been used over the course of history in traditional medicine. The aim of this study was to evaluate the in vitro anticoccidial effects of Allium sativum L. (garlic), Artemisia absinthium L. (wormwood), Coriandrum sativum L. (coriander), Cucurbita pepo L. (pumpkin), Satureja hortensis L. (summer savory), and Calendula officinalis L. (marigold) against Eimeria suis and Eimeria debliecki oocysts. The stock solution of oocysts (58% E. suis + 42% E. debliecki) was incubated for three days, before adding the tested solutions. The unsporulated Eimeria spp. oocysts were then placed in a 3 mL well plate and incubated for 96 h at 27 °C, in a suspension containing serial dilutions of alcoholic plant extracts (5%, 2.5%, 1.25%, 0.625%, and 0.312%). The percentage of sporulated and destroyed oocysts was recorded every 24 h for 96 h. All extracts had a good in vitro anticoccidial effect against oocysts of Eimeria spp. compared with the control groups. Oocyst sporulation was significantly (p = 0.05) inhibited by the 5% marigold extract (3.6% sporulated oocysts). The same extract had the highest lytic effect on oocysts (65.2% destroyed oocysts). Our results prove that the most effective alcoholic plant extract is the marigold extract, followed, in order of efficiency, by the wormwood, coriander, garlic, pumpkin, and summer savory extracts. This study represents a preliminary contribution for establishing a new generation of natural disinfectants aimed at destroying Eimeria oocysts in the context of swine contamination.

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Nematicidal activity of essential oils of medicinal plants

Cited by 18 publications

References 41 publications

Preliminary screening of plant essential oils from an oceanic climate zone (NW Spain) for the control of equine cyathostomins

Preliminary screening of plant essential oils from an oceanic climate zone (NW Spain) for the control of equine cyathostomins

Influence of Lavandula angustifolia, Melissa officinalis and Vitex angus-castus on the organism of rats fed with excessive fat-containing diet

The In Vitro Anticoccidial Activity of Some Herbal Extracts against Eimeria spp. Oocysts Isolated from Piglets

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