Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer

H, Yan; Shang, Wenting; Sun, Xiaodan; Zhao, Lingyun; Xiu-mei, Wang; Zhang, Shuixing; Xu, Nan; Xu, Wanhai; Hui, Hui; Kang, Feiyu

doi:10.1039/c8nr08109c

Cited by 17 publications

(15 citation statements)

References 35 publications

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“…Magnetic fluid hyperthermia as a special physical way，which could increase the temperature above 42°C and targeted to various tumor cells and tissues, has gained more and more attention and recognition 18. Superparamagnetic iron oxide nanoparticles have been widely used in imaging, drug delivery and heating,27,28 and their combination with surgery, radiotherapy, chemotherapy and even ultrasound29 has shown excellent outcomes in both in vitro and in vivo experiments on liver,30,31 breast,32–35 colon36–39 and brain cancers 40–43…”

Section: Discussionmentioning

confidence: 99%

Preparation and Characterization of Fe3O4@MTX Magnetic Nanoparticles for Thermochemotherapy of Primary Central Nervous System Lymphoma in vitro and in vivo

Dai¹,

Yao²,

Zhong³

et al. 2019

IJN

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BackgroundPrimary central nervous system lymphomas (PCNSL) are extranodal malignant non-Hodgkin lymphomas (NHL) that arise exclusively in central nervous system (CNS). Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype.PurposeTo evaluate whether nano drug-loading system-mediated magnetic-targeted thermochemotherapy could produce a better therapeutic effect than single chemotherapy while reducing the use of chemotherapeutic drugs.MethodsSix groups (control, Fe3O4, MTX, Fe3O4@MTX, Fe3O4 with hyperthermia and Fe3O4@MTX with hyperthermia) were set. Tumor cell apoptosis in each treatment group was detected by flow cytometry. Apoptosis-related gene expressions Caspase-3, Bax and Bcl-2 were detected by qPCR and Western blot; intracranial tumor model of PCNSL was established by intracranial injection of OCI-LY18 tumor cells into BALB/c-Nude mice. Magnetic resonance imaging (MRI) was used to monitor tumor progression and H&E staining was used to observe pathological changes of the tumor tissue.ResultsIn vitro, compared with chemotherapy alone, apoptosis rate of Fe3O4@MTX mediated thermochemotherapy group was significantly increased, and expression of apoptosis-inducing gene Caspase-3 and Bax were significantly upregulated in OCI-LY18 cells, while expression of apoptosis-inhibiting Bcl-2 gene was significantly downregulated. In vivo, MRI showed successful generation of intracranial tumor, and tumor volume was significantly smaller in combined thermochemotherapy group than in single chemotherapy group. H&E staining result of tumor tissues in each group was consistent with MRI; tumor cells were significantly reduced in thermochemotherapy group. Expression of apoptosis-related gene Caspase-3 and Bax were significantly upregulated in tumor tissues, while expression of Bcl-2 gene was significantly downregulated.ConclusionThese results demonstrated in vivo and in vitro that the combined thermochemotherapy of Fe3O4@MTX MNPs was superior to the single MTX chemotherapy with less dosage, which may promote apoptosis of DLBCL cells through the mitochondrial apoptotic pathway and provided a new way for the treatment of PCNSL.

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Section: Discussionmentioning

confidence: 99%

Preparation and Characterization of Fe3O4@MTX Magnetic Nanoparticles for Thermochemotherapy of Primary Central Nervous System Lymphoma in vitro and in vivo

Dai¹,

Yao²,

Zhong³

et al. 2019

IJN

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“…[183,244,[318][319][320][321][322][323] Compared with conventional radiotherapy, PTT has the advantage in specificity without radiation and can potentially be an alternative to radiotherapy. [183,244,[318][319][320][321][322][323] Compared with conventional radiotherapy, PTT has the advantage in specificity without radiation and can potentially be an alternative to radiotherapy.…”

Section: Synergistic Surgery With Pttmentioning

confidence: 99%

“…[321] Compared with intraoperative PTT that is mainly applied to eliminate MRDs for improving surgical outcomes, neoadjuvant NPTT reduces tumors to facilitate subsequent resection, thereby possibly providing cancer patients who were previously evaluated to be inoperable with additional chances of resection surgery, as well as boosted surgical outcomes. [321] Compared with intraoperative PTT that is mainly applied to eliminate MRDs for improving surgical outcomes, neoadjuvant NPTT reduces tumors to facilitate subsequent resection, thereby possibly providing cancer patients who were previously evaluated to be inoperable with additional chances of resection surgery, as well as boosted surgical outcomes.…”

Section: Synergistic Surgery With Pttmentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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“…Results showed that tumors could be eliminated completely under the high effective and precise dual‐mode hyperthermia under the guidance of tri‐modality imaging (i.e., photoacoustic/near‐infrared fluorescence/magnetic resonance) (see Figure 19D). Kang and co‐workers [ 155 ] further developed another optical‐magnetic nanoplatforms (MNP@PES‐dye800/FA) for preoperative nano‐photothermal therapy (NPTT) and assist in the follow‐up surgery under the tri‐modality molecular imaging guidance. Contributed by the adjuvant effect of preoperative NPTT, the tumor boundary is more clear for surgical resection, then leading to a better survival rate of tumor‐bearing mice models.…”

Section: The Applications Of Fmions In Cancer Theranosticsmentioning

confidence: 99%

Recent advances of high performance magnetic iron oxide nanoparticles: Controlled synthesis, properties tuning and cancer theranostics

Liang

Xie

et al. 2020

Nano Select

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Recently, magnetic nanomaterials have emerged as multifunctional materials for a wide range of biomedical applications. Functional magnetic iron oxide nanoparticles (FMIONs) are typical magnetic nanomaterials with inherent advantages for disease diagnosis, prevention, and treatment: high specific surface area, excellent superparamagnetism, good colloidal stability, and remarkable biosafety. Therefore, FMION‐based biomedicine has advanced at an unprecedented rate in recent years. However, the performance of FMIONs cannot yet meet complicated physiological circumstances. To overcome these limitations, researchers have designed and manipulated the geometric shapes, sizes, compositions, and surfaces to endow these FMIONs with high performance. This review summarizes recent advances in the controlled synthesis of FMIONs, cover corresponding theories of nucleation and growth in solution, and the tuning of FMION properties for disease diagnosis and therapy. After discussing the biomedical applications in cancer theranostics—tumor hyperthermia, magnetic resonance imaging and drug delivery system—in detail, the review concludes with current challenges and outlooks for the development of FMIONs.

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Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer

Abstract: The neoadjuvant nano-photothermal therapy used before operation could shrink the tumor in a short time and make the boundary clearer, thus greatly assisting subsequent surgery resection and improving the surgery effect finally.

Cited by 17 publications

References 35 publications

<p>Preparation and Characterization of Fe<sub>3</sub>O<sub>4</sub>@MTX Magnetic Nanoparticles for Thermochemotherapy of Primary Central Nervous System Lymphoma in vitro and in vivo</p>

<p>Preparation and Characterization of Fe<sub>3</sub>O<sub>4</sub>@MTX Magnetic Nanoparticles for Thermochemotherapy of Primary Central Nervous System Lymphoma in vitro and in vivo</p>

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Recent advances of high performance magnetic iron oxide nanoparticles: Controlled synthesis, properties tuning and cancer theranostics

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