Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells

Kim, Young-Joo; Choi, Won-Il; Ko, Hyeonseok; So, Youngsin; Kang, Ki Sung; Kim, InKi; Kim, Kunhong; Yoon, Ho‐Geun; Kim, Tae-Jin; Choi, Kyung‐Chul

doi:10.1016/j.lfs.2013.10.035

Cited by 26 publications

(14 citation statements)

References 19 publications

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“…Given that TRAIL is known to trigger apoptosis through binding to its cell surface death receptors, DR4 and DR5, the expression levels of these death receptors may be critical to determining the intensity and/or duration of TRAIL-induced apoptotic signaling [ 8 , 9 , 66 ]. We recently showed that the DR5 up-regulating agent, neobavaisoflavone, effectively stimulates TRAIL-mediated apoptosis in prostate cancer cells via the intrinsic pathway [ 67 ]. In this study, we find that delphinidin increases the protein level of DR5 in prostate cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage

Jeong

Jeon

et al. 2015

Oncotarget

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TRAIL can induce apoptosis in some cancer cells and is an immune effector in the surveillance and elimination of developing tumors. Yes, some cancers are resistant to TRAIL. Delphinidin, a polyphenolic compound contained in brightly colored fruits and vegetables, has anti-inflammatory, anti-oxidant, and anti-tumorigenic activities. Here we showed that delphinidin sensitized TRAIL-resistant human prostate cancer cells to undergo apoptosis. Cells treated with delphinidin and TRAIL activated the extrinsic and intrinsic pathways of caspase activation. TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3). In conclusion, delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis by inducing DR5, thus causing caspase-mediated HDAC3 cleavage. Our data reveal a potential way of chemoprevention of prostate cancer by enabling TRAIL-mediated apoptosis.

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Section: Discussionmentioning

confidence: 99%

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage

Jeong

Jeon

et al. 2015

Oncotarget

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“…Psoralea corylifolia contains, other than neobavaisoflavone, several active compounds including psoralen, isopsoralen, psoralidin, isobavachalcone, bavachin and bakuchiol [220]. Moreover, Psoralea corylifolia seeds have been reported to possess a high activity against the SARS-CoV papain-like protease (PLpro) which is the main enzyme involved in SARS virus replication [221]. In fact, six phenolic compounds with an antiviral activity were isolated from the ethanolic extracts of Psoralea corylifolia identified as, bavachinin, neobavaisoflavone, isobavachalcone, 4′-O-methylbavachalcone, psoralidin and corylifol A. Isobavachalcone and psoralidin were the greatest antiviral inhibitors of SARS-CoV PLpro [222].…”

Section: Neobavaisoflavonementioning

confidence: 99%

“…Moreover, Psoralea corylifolia seeds have been reported to possess a high activity against the SARS‐CoV papain‐like protease (PLpro) which is the main enzyme involved in SARS virus replication [ 221 ]. In fact, six phenolic compounds with an antiviral activity were isolated from the ethanolic extracts of Psoralea corylifolia identified as, bavachinin, neobavaisoflavone, isobavachalcone, 4′-O-methylbavachalcone, psoralidin and corylifol A. Isobavachalcone and psoralidin were the greatest antiviral inhibitors of SARS-CoV PLpro [ 222 ]. Actually, Neobavaisoflavone has numerous biological properties such as antibacterial, anti-fungal, anti-inflammatory, antioxidative, anti-cancer, anti-osteoporosis and anti-platelet aggregation [ 223 , 224 ].…”

Section: Neobavaisoflavonementioning

confidence: 99%

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

Khalil

Tazeddinova

2020

Nat. Prod. Bioprospect.

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Polyphenols are a large family of more than 10,000 naturally occurring compounds, which exert countless pharmacological, biological and physiological benefits for human health including several chronic diseases such as cancer, diabetes, cardiovascular, and neurological diseases. Their role in traditional medicine, such as the use of a wide range of remedial herbs (thyme, oregano, rosemary, sage, mint, basil), has been well and long known for treating common respiratory problems and cold infections. This review reports on the most highlighted polyphenolic compounds present in up to date literature and their specific antiviral perceptive properties that might enhance the body immunity facing COVID-19, and other viral infectious diseases. In fact, several studies and clinical trials increasingly proved the role of polyphenols in controlling numerous human pathogens including SARS and MERS, which are quite similar to COVID-19 through the enhancement of host immune response against viral infections by different biological mechanisms. Thus, polyphenols ought to be considered as a potential and valuable source for designing new drugs that could be used effectively in the combat against COVID‐19 and other rigorous diseases.

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“…In several studies, NBIF has proven to decrease cell viability in cancer cells [27][28][29]. This effect was demonstrated by Kim et al [29] in U-373 MG glioma cells.…”

Section: Discussionmentioning

confidence: 82%

Neobavaisoflavone May Modulate the Activity of Topoisomerase Inhibitors towards U-87 MG Cells: An In Vitro Study

et al. 2021

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Despite many advances in therapy, glioblastoma (GB) is still characterized by its poor prognosis. The main reason for this is unsuccessful treatment, which slightly extends the duration of remission; thus, new regimens are needed. One of many types of chemotherapeutics that are being investigated in this field is topoisomerase inhibitors, mainly in combination therapy with other drugs. On the other hand, the search for new anti-cancer substances continues. Neobavaisoflavone (NBIF) is a natural compound isolated from Psoralea corylifolia L., which possesses anti-oxidant, anti-inflammatory, and anti-cancer properties. The aim of this study was to evaluate the effect of NBIF in human U-87 MG glioblastoma cells in comparison to normal human NHA astrocytes, and to examine if it influences the activity of irinotecan, etoposide, and doxorubicin in this in vitro model. We demonstrated that NBIF decreases U-87 MG cells viability in a dose-dependent manner. Furthermore, we found that it inhibits cell growth and causes glutathione (GSH) depletion more intensely in U-87 MG cells than in astrocytes. This study also provides, for the first time, evidence of the potentialization of the doxorubicin effect by NBIF, which was shown by the reduction in the viability in U-87 MG cells.

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Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells

Cited by 26 publications

References 19 publications

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

Neobavaisoflavone May Modulate the Activity of Topoisomerase Inhibitors towards U-87 MG Cells: An In Vitro Study

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