2016
DOI: 10.1038/ncomms11082
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Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Abstract: To maintain tissue integrity during epithelial morphogenesis, adherens junctions (AJs) must resist the mechanical stresses exerted by dynamic tissue movements. Junctional stability is dependent on actomyosin contractility within the actin ring. Here we describe a novel function for the axon guidance receptor, Neogenin, as a key component of the actin nucleation machinery governing junctional stability. Loss of Neogenin perturbs AJs and attenuates junctional tension. Neogenin promotes actin nucleation at AJs by… Show more

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Cited by 38 publications
(64 citation statements)
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References 61 publications
(116 reference statements)
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“…Neogenin also affects E-cadherin recycling, but whether this effect depends on its ability to control actin dynamics is unknown. Knockdown of RGMa induces defects in AJ stability and WRC localization similar to those observed following Neogenin depletion [62]. This suggests that RGMa and Neogenin act together at the AJ.…”
Section: Actin Regulation During Epithelial Cell Adhesionsupporting
confidence: 52%
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“…Neogenin also affects E-cadherin recycling, but whether this effect depends on its ability to control actin dynamics is unknown. Knockdown of RGMa induces defects in AJ stability and WRC localization similar to those observed following Neogenin depletion [62]. This suggests that RGMa and Neogenin act together at the AJ.…”
Section: Actin Regulation During Epithelial Cell Adhesionsupporting
confidence: 52%
“…The actin ring undergoes continuous turnover and failure to rebuild the ring causes loss of adhesion. Interestingly, recent work identified Neogenin as a key component of the actin nucleation machinery governing AJ stability [62]. Neogenin promotes the formation of stable actin rings at AJs by spatially coupling Arp2/3-mediated actin nucleation to the AJ via recruitment of the wave regulatory complex (WRC) (Figure 2).…”
Section: Actin Regulation During Epithelial Cell Adhesionmentioning
confidence: 99%
“…3B). Neogenin also recruits the WAVE regulatory complex (WRC) and activates the actin related protein 2/3 complex (Arp2/3) (Lee et al 2016). The WRC comprises five subunits organized into the Sra/Nap and WAVE/Abi/HSPC300 subcomplexes Verma et al 2012).…”
Section: Netrins and Adherens Junctionsmentioning
confidence: 99%
“…The WRC comprises five subunits organized into the Sra/Nap and WAVE/Abi/HSPC300 subcomplexes Verma et al 2012). Neogenin directly interacts with, and recruits, the WRC to AJs via a WRC interacting receptor sequence (WIRS) present in its cytoplasmic domain (Lee et al 2016). This interaction requires Rac activation downstream from RGMa-mediated engagement of neogenin and leads to Arp2/3 activation at AJs that modulates tension through peri-junctional nucleation of F-actin (Lee et al 2016).…”
Section: Netrins and Adherens Junctionsmentioning
confidence: 99%
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