The process of development of universities from the places where medieval elites met to conduct alliances and partnerships to the modern biotechnological and digital institutions of higher education, research and business took several centuries and went through four main stages. This paper describes the role and the place of the University 4.0 within the context of the sustainable development of higher education in the 21st century. We show that University 4.0 is designed to promote the technology industry through partnerships that support research, marketing, workforce development, as well as entrepreneurship. In keeping with the cooperative nature efforts directed and driven by the policy-makers and relevant stakeholders need to be dedicated to promoting modern universities as hub for the development of intelligent, connected technologies and services that would lead to the sustainable development of higher education that would reflect the challenges of our time.