Neolignans and an isoprenylated phenol from Piper clarkii

Chemical Composition of Leaves, Stem, and Roots of Peperomia pellucida (L.) Kunth

“…2′,4′,5′-trihydroxybutyrophenone has been applied as food antioxidant [ 58 , 59 ]. Velutin has already been detected in Piper species such as Piper porphyrophyllum [ 60 ], Piper umbellata [ 61 ], and Piper clarkii [ 62 ], and it has already been reported as having antibacterial activity [ 63 ], anti-melanogenic activity [ 64 ], human immunodeficiency virus (HIV-1) activity, and as being against Trypanosoma cruzi [ 65 ]. In previous reports, pipercallosidine showed anesthetic activity [ 66 ], and dehydroretrofractamide C showed inhibition ACAT activity in both rat liver microsomes and HepG2 cancer cells [ 41 ].…”

Flavonas, lignanas e terpeno de Piper umbellata (Piperaceae)

“…42,50 A substância 7 foi identificada como sendo a velutina, previamente isolada dos caules e das folhas de Piper clarkii. 42,51 As substâncias 5 e 8 foram identificadas como sendo as lignanas sesamina e diidrocubebina, as quais já foram isoladas de várias espé-cies de Piper, incluindo Piper brachystachyum Wall, P. retrofractum, P. peepuloides, P. guineense e P. cubeba. 7,52,53 …”

Unusual Bicyclo[3.2.1]Octanoid Neolignans from Leaves of Piper crocatum and Their Effect on Pyruvate Dehydrogenase Activity

“…However, a correlation between H-8 and H-4 was observed. Therefore, the trans-relationship of methyl (H-9) and aryl groups was confirmed [ 4 ]. Additionally, the correlations between H-2′, –OH-2′, and H-9 were observed, which indicated the endo conformation of the hydroxy group on C-2′.…”

“…Piper species have been widely investigated, and a number of physiological activity components have been isolated, which can be characterized into the typical classes of alkaloids, amides, chalcones, dihydrochalcones, flavanones, lignans, neolignans, propenylphenols, steroids, and terpenes [ 1 ]. However, only a few chemical investigations of P. crocatum have been reported, which were limited to sterols, lignans, and neolignans [ 2 , 3 , 4 ]. In China, people have used the dried stem of Piper kadsura (Choisy) Ohwi as a traditional Chinese medicine to treat asthma and rheumatism for hundreds of years.…”