Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-&amp;#945; inhibitory activity

Bezerra, Amanda de Melo; Lins, Antônio Cláudio da Silva; Athayde-Filho, Petrônio Filgueiras de; Silva, Marcelo Sobral da; Barbosa-Filho, José Maria; Câmara, Celso A.; Silva, Tânia Maria Sarmento; Luna, Vanessa da Silva; Santos, Creusioni Figueredo dos

doi:10.1590/s0100-40422012001100024

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…In addition, the configuration of the tetrahydrofuran ring was also identified by comparing the chemical shifts of C-7/7′, C-8/8′, and C-9/9′ with reported data. The chemical shifts for the different configurations of the tetrahydrofuran-type lignans are summarized in Figure . ,,− …”

Section: Resultsmentioning

confidence: 99%

Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein–Barr Virus Lytic Replication

Cui

et al. 2013

J. Nat. Prod.

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Epstein-Barr virus (EBV) is a member of the γ-herpes virus subfamily and has been implicated in the pathogenesis of several human malignancies. Bioassay-guided fractionation was conducted on an EtOAc-soluble extract of the roots of Saururus chinensis and monitored using an EBV lytic replication assay. This led to the isolation of 19 new (1-19) and nine known (20-28) lignans. The absolute configurations of the new lignans were established by Mosher's ester, ECD, and computational methods. Eight lignans, including three sesquineolignans (19, 23, and 24) and five dineolignans (3, 4, 26, 27, and 28), exhibited inhibitory effects toward EBV lytic replication with EC50 values from 1.09 to 7.55 μM and SI values from 3.3 to 116.4. In particular, manassantin B (27) exhibited the most promising inhibition, with an EC50 of 1.72 μM, low cytotoxicity, CC50 > 200 μM, and SI > 116.4. This is the first study demonstrating that lignans possess anti-EBV lytic replication activity.

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Section: Resultsmentioning

confidence: 99%

Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein–Barr Virus Lytic Replication

Cui

et al. 2013

J. Nat. Prod.

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Bioinspired total synthesis of tetrahydrofuran lignans by tandem nucleophilic addition/redox isomerization/oxidative coupling and cycloetherification reactions as key steps

2018

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A very short three-step approach to trans,trans,trans-2,5-diaryl-3,4-dimethyltetrahydrofuran lignans is reported. The carbon skeleton is assembled in a single step based on an unprecedented tandem reaction consisting of 1,2-addition of aryllithium reagents to α,β-unsaturated aldehydes, ruthenium-catalyzed redox isomerization of the resulting alkoxides to enolates and their dimerization triggered by single electron oxidation. The resulting 2,3-dialkyl-1,4-diketones form with moderate to good d/l-diastereoselectivity and are transformed to the target tetrahydrofuran lignans by reduction and diastereoselective cycloetherification.

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Review on Phytochemistry and Pharmacology of the Genus Licaria (Lauraceae)

Salleh

Ahmad

2016

Marmara Pharm J

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The genus Licaria (Lauraceae) is a flowering plant genus, comprises 40 species and endemic to Central and South America. Most of the species have been used as traditional medicine. Phytochemicals isolated from Licaria species are lignans, neolignans, alkaloids, lactones, triterpenes, and arylpropanoids. The purpose of this review is to examine in detail from a phytochemical and pharmacological point of view what is reported in the past and current literature obtained from plants belonging to the Licaria genus.

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Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Cited by 3 publications

References 17 publications

Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein–Barr Virus Lytic Replication

Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein–Barr Virus Lytic Replication

Bioinspired total synthesis of tetrahydrofuran lignans by tandem nucleophilic addition/redox isomerization/oxidative coupling and cycloetherification reactions as key steps

Review on Phytochemistry and Pharmacology of the Genus Licaria (Lauraceae)

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