Neonatal candida septicaemia: diagnosis on buffy smear.

Cattermole, H E J; Rivers, R. P. A.

doi:10.1136/adc.62.3.302

Cited by 16 publications

(1 citation statement)

References 6 publications

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“…In addition, other factors may play a role in predisposing to the infection such as use of total parenteral nutri-tion, intravenous additives, use of central lines particularly for long duration, prolonged endotracheal intubation and the use of drugs such as theophylline [2,3,6,8,[12][13][14][15]. There are clinical, hematological and biochemical parameters by which Candida infection is suspected and treatment is therefore initiated since blood cultures are not always positive [11,[15][16][17]. Mortality rate from Candida infection varies from 10 to 55% in extremely premature babies; there are no studies to define the long-term outcome in the survivors [9,14,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Pattern of Candidiasis in the Newborn: A Study from Kuwait

Al-Essa

Khan

Rashwan³

et al. 2000

Med Princ Pract

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Objectives: To determine the rate and pattern of Candida infection in a large neonatal unit in Kuwait. Methods: A prospective study of all newborn infants who were admitted to the neonatal intensive care unit (NICU) at Maternity Hospital in Kuwait during the year of 1997 and who were suspected of having Candida infection were collected and analyzed. Method of selection of neonates, laboratory parameters and possible risk factors of the infection were identified and defined. Results:Candida infection was recognized in 22 (8.4%) cases out of 263 total infants admitted to the NICU. All the proven cases originated from 168 infants of birth weight less than 2,000 g with an incidence of 13%. In addition, Candida infection was suspected and treated without positive culture in 15 infants (5.7%). Cases with proven Candida sepsis had longer mean duration of endotracheal intubation (p < 0.03) and total parenteral nutrition (p < 0.03) and more episodes of concomitant bacterial infection (p < 0.01) compared to infants with suspected candidiasis. Conclusion: For an early diagnosis of candidiasis, a high index of suspicion in septic low-birth weight infants is always warranted since the clinical and laboratory diagnostic parameters are difficult to differentiate between suspected and proven cases.

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Section: Introductionmentioning

confidence: 99%

Pattern of Candidiasis in the Newborn: A Study from Kuwait

Al-Essa

Khan

Rashwan³

et al. 2000

Med Princ Pract

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Candidemia Diagnosed from Peripheral Blood Smear: Case Report and Review of Literature 1954–2013

et al. 2015

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We analysed 36 cases including the present case. Almost all CPBS patients (96.5 %, n = 29) were using an intravenous catheter. The most frequently isolated species was C. parapsilosis (35.1 %), followed by C. albicans (29.7 %). The overall mortality rate was 53.6 % (n = 28). The time from the discovery of yeast-like pathogens using peripheral blood smears to death ranged from a few hours to 93 days (median 19 days). The present results suggest that intravenous catheter use and the underlying conditions of patients are responsible for CPBSs. The detection of yeast in peripheral blood smears suggests advanced infections with uncontrollable complications, which means a poor prognosis. Rapid detection methods besides blood culture are needed.

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