Neonatal exposure to whole body ionizing radiation induces adult neurobehavioural defects: Critical period, dose—response effects and strain and sex comparison

Eriksson, Per; Buratovic, Sonja; Fredriksson, Anders; Stenerlöw, Bo; Sundell‐Bergman, Synnöve

doi:10.1016/j.bbr.2016.02.008

Cited by 26 publications

(24 citation statements)

References 36 publications

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“…Another is described earlier as there are differences between sexes in the hippocampus in terms of both function and structure (Goldstein et al ., ; Madeira & Lieberman, ; Romeo et al ., ). In our neonatal mouse model, we have previously evaluated potential sex differences for both environmental contaminants and irradiation; however, none of these studies revealed any sex‐related differences in adult spontaneous behavior after neonatal exposure (Buratovic et al ., ; Eriksson et al ., ; Viberg et al ., ). The fact that environmental contaminants, irradiation and now paracetamol affect male and female brain development in the same manner may be regarded as a sign of how important and fundamental the processes are during the BGS.…”

Section: Discussionmentioning

confidence: 98%

Adult neurobehavioral alterations in male and female mice following developmental exposure to paracetamol (acetaminophen): characterization of a critical period

et al. 2017

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Paracetamol (acetaminophen) is a widely used non-prescription drug with analgesic and antipyretic properties. Among pregnant women and young children, paracetamol is one of the most frequently used drugs and is considered the first-choice treatment for pain and/or fever. Recent findings in both human and animal studies have shown associations between paracetamol intake during brain development and adverse behavioral outcomes later in life. The present study was undertaken to investigate if the induction of these effects depend on when the exposure occurs during a critical period of brain development and if male and female mice are equally affected. Mice of both sexes were exposed to two doses of paracetamol (30 + 30 mg kg , 4 h apart) on postnatal days (PND) 3, 10 or 19. Spontaneous behavior, when introduced to a new home environment, was observed at the age of 2 months. We show that adverse effects on adult behavior and cognitive function occurred in both male and female mice exposed to paracetamol on PND 3 and 10, but not when exposed on PND 19. These neurodevelopmental time points in mice correspond to the beginning of the third trimester of pregnancy and the time around birth in humans, supporting existing human data. Considering that paracetamol is the first choice treatment for pain and/or fever during pregnancy and early life, these results may be of great importance for future research and, ultimately, for clinical practice. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 98%

Adult neurobehavioral alterations in male and female mice following developmental exposure to paracetamol (acetaminophen): characterization of a critical period

et al. 2017

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“…There is also limited evidence suggesting a link between exposure to ionised radiation in children with neurodevelopmental disorders or delays [9], although these findings have not been supported by a recent study from Sweden [10]. Despite lack of consensus, there is ongoing concern for the developing brain exposed to ionised radiation and recent novel studies on infant mice, may have again found an association with low to moderate doses of ionised radiation and neurofunctional disorders and/or reduced cognitive capacity [11]. Obviously, further studies exploring the effect of neuroimaging on the developing brain in humans are required.…”

Section: Introductionmentioning

confidence: 88%

Management of paediatric periorbital cellulitis: Our experience of 243 children managed according to a standardised protocol 2012–2015

Crosbie

Nairn

Kubba

2016

International Journal of Pediatric Otorhinolaryngology

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“…Altered adult spontaneous behavior and impaired habituation capacity was found in mice exposed to low doses (500 mGy) total-body irradiation at a very young age (postnatal day 3 and 10) but not later, indicating an exquisite sensitivity of the young brain to IR. The same group showed significantly higher alterations in the behavior of these mice if they were coexposed to IR and nicotine (132, 133). Gene expression studies performed in the brain or various brain structures repeatedly report mRNA expression profiles characteristic for low-dose exposure.…”

Section: Low-dose Radiation Effects On the Brainmentioning

confidence: 96%

Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain

2017

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Radiation-induced late brain injury consisting of vascular abnormalities, demyelination, white matter necrosis, and cognitive impairment has been described in patients subjected to cranial radiotherapy for brain tumors. Accumulating evidence suggests that various degrees of cognitive deficit can develop after much lower doses of ionizing radiation, as well. The pathophysiological mechanisms underlying these alterations are not elucidated so far. A permanent deficit in neurogenesis, chronic microvascular alterations, and blood–brain barrier dysfunctionality are considered among the main causative factors. Chronic neuroinflammation and altered immune reactions in the brain, which are inherent complications of brain irradiation, have also been directly implicated in the development of cognitive decline after radiation. This review aims to give a comprehensive overview on radiation-induced immune alterations and inflammatory reactions in the brain and summarizes how these processes can influence cognitive performance. The available data on the risk of low-dose radiation exposure in the development of cognitive impairment and the underlying mechanisms are also discussed.

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Neonatal exposure to whole body ionizing radiation induces adult neurobehavioural defects: Critical period, dose—response effects and strain and sex comparison

Cited by 26 publications

References 36 publications

Adult neurobehavioral alterations in male and female mice following developmental exposure to paracetamol (acetaminophen): characterization of a critical period

Adult neurobehavioral alterations in male and female mice following developmental exposure to paracetamol (acetaminophen): characterization of a critical period

Management of paediatric periorbital cellulitis: Our experience of 243 children managed according to a standardised protocol 2012–2015

Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain

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