Neonatal Graves' Disease

Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI).

“…Barnes, G. L., Gwynne, J. F., and Watt, J. M. (1970) Neonatal thyrotoxicosis accompanying or following maternal thyrotoxicosis was first described by White (1912) and is usually temporary. Mackenzie (1964) presented evidence that the disorder was related to transplacental passage of long-acting thyroid stimulator (LATS), an immunoglobulin-G, but Mahoney et al (1964) described a case in which LATS was present in the mother but not in the child. Nutt et al (1974) reported a case in which LATS was not found in mother or baby, but another immunoglobulin, LATS-P (now known as HTSI), was detected in the mother.…”

Thyroid Crisis in a 3‐year‐old Girl

“…We tried, with less effect, to treat the tachycardia and the threatening cardiac insufficiency with digitalis. The neonatal crisis cases, described in the literature (10,13,16), with cardiac insufficiency, reacted well, however, to the administration of digitalis. Good results have been achieved in recent years with reserpine 0.1 mg per kg for children, or guanethidin 0.5 mg-2 mg per kg during 1-3 weeks, with the object of reducing sympatho-adrenergic symptoms, such as tachycardia, hypertension, and tremor during the acute stage (21).…”