Neonatal Handling Impairs Spatial Memory and Leads to Altered Nitric Oxide Production and DNA Breaks in A Sex Specific Manner

Noschang, Cristie; Krolow, Rachel; Fontella, Fernanda Urruth; Arcego, Danusa Mar; Diehl, Luisa Amalia; Weis, Simone Nardin; Arteni, Nice Sarmento; Dalmaz, Carla

doi:10.1007/s11064-010-0158-7

Cited by 23 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, enhanced effects of prolonged separation were seen as better reversal learning (Lehmann et al, 1999; Levy et al, 2003). Among studies that report impaired MWM performance, these reflect either increased latency and greater distance to reach the platform (Garner et al, 2007; Huang et al, 2002; Huot et al, 2002; Noschang et al, 2010; Oitzl et al, 2000; Oomen et al, 2010), lower swim distance or time in the former location of the platform during a probe test (Aisa et al, 2009a; Aisa et al, 2009b; Aisa et al, 2007; Brunson et al, 2001; Brunson et al, 2005; Hui et al, 2011; Ivy et al, 2010; Solas et al, 2010), or impaired reversal learning (Ivy et al, 2010; Lehmann et al, 1999; Oitzl et al, 2000). No effect of early life manipulations on MWM was seen in 15 studies (Choy et al, 2008; Gibb and Kolb, 2005; Huot et al, 2002; Ivy et al, 2010; Lai et al, 2006; Oitzl et al, 2000; Oomen et al, 2011; Pryce et al, 2003; Vallee et al, 1999; Vallee et al, 1997).…”

Section: Early Life Stress Effects On Learning and Memory: Spatialmentioning

confidence: 99%

Early life manipulations alter learning and memory in rats

Kosten

Kim

Lee

2012

Neuroscience & Biobehavioral Reviews

124

View full text Add to dashboard Cite

Much research shows early life manipulations have enduring behavioral, neural, and hormonal effects. However, findings of learning and memory performance vary widely across studies. We reviewed studies in which pre-weaning rat pups were exposed to stressors and tested on learning and memory tasks in adulthood. Tasks were classified as aversive conditioning, inhibitory learning, or spatial/relational memory. Variables of duration, type, and timing of neonatal manipulation and sex and strain of animals were examined to determine if any predict enhanced or impaired performance. Brief separations enhanced and prolonged separations impaired performance on spatial/relational tasks. Performance was impaired in aversive conditioning and enhanced in inhibitory learning tasks regardless of manipulation duration. Opposing effects on performance for spatial/relational memory also depended upon timing of manipulation. Enhanced performance was likely if the manipulation occurred during postnatal week 3 but performance was impaired if it was confined to the first two postnatal weeks. Thus, the relationship between early life experiences and adulthood learning and memory performance is multifaceted and decidedly task-dependent.

show abstract

Section: Early Life Stress Effects On Learning and Memory: Spatialmentioning

confidence: 99%

Early life manipulations alter learning and memory in rats

Kosten

Kim

Lee

2012

Neuroscience & Biobehavioral Reviews

124

View full text Add to dashboard Cite

show abstract

“…Perhaps the findings observed in the present study might also imply that our deficient diet was able to significantly alter the machinery of antioxidant enzymes. Our group and others have already demonstrated that neonatal handling leads to differences in adolescent and adult rats on neurochemical and behavioral parameters [50][51][52][53][54]73]. We also demonstrated that H and MS, exposed chronically to n-3 PUFAs deficiency, displayed lower brain derived neurotrophic factor protein in hippocampus (BDNF) [20].…”

Section: Discussionmentioning

confidence: 65%

“…This result might be related to an early apoptosis characteristic, maybe induced by oxidative damage. Noschag et al [50] reported that neonatal handled male rats display, when adults, higher DNA break levels in hippocampus, what could be due to oxidative imbalance. Another focus to consider are the possible epigenetics and post translational modifications involved in these processes.…”

Section: Discussionmentioning

confidence: 99%

“…Contrariwise, early maternal separated animals (separation of pups from their dams for longer periods) may involve a range of effects, in adulthood, including changes in the secretion of neurotransmitters, proinflammatory cytokines, increased stress hormones, and epigenetic modifications, resulting in synaptic remodeling and structural changes in neurons [48,49]. Studies from our research group illustrated that adult male rats exposed to neonatal stress exhibit increased DNA breaks index, impairment in nitric oxide production and altered antioxidant enzymatic activity level in hippocampus [50][51][52][53][54].…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Mitochondrial and Oxidative Stress Aspects in Hippocampus of Rats Submitted to Dietary n-3 Polyunsaturated Fatty Acid Deficiency After Exposure to Early Stress

et al. 2015

Self Cite

View full text Add to dashboard Cite

Chronic dietary long-chain polyunsaturated fatty acids (PUFAs) deficiency may lead to changes in cortex and hippocampus neuronal membrane phospholipids, and may be linked to impaired central nervous system function. Particularly docosahexaenoic acid deficiency appears to be involved in neuropsychiatric disorders. On the other hand, adverse events early in life may also profoundly affect brain development, leading to long-lasting effects on neurophysiology, neurobiology and behavior. This research assessed if neonatal stress and a dietary n-3 PUFAs deficiency could interact to produce hippocampal alterations related to mitochondrial functions in adult rats. There were no effects of diet, neonatal intervention or interactions on superoxide dismutase or catalase enzymatic activities, mitochondrial membrane potential and respiratory chain complexes. Rats fed n-3 PUFAs deficient diet displayed higher levels of glutathione peroxidase and catalase activity, higher free radicals production and higher thiol content compared to rats fed n-3 PUFAs adequate diet. There were interactions among diets and neonatal stress, since glutathione peroxidase, free radicals production and thiol content were increased in groups that were subjected to neonatal interventions fed n-3 PUFAs deficient diet. Additionally, reduced mitochondrial potential was observed in handled animals. Total thiol revealed a neonatal stress effect, since animals subjected to neonatal interventions displayed lower thiol content. In conclusion, we observed that a chronic treatment with deficient n-3 PUFAs diet, from the puberty period on, increased free radicals production and imbalanced antioxidant enzymes activities, and these increases were higher in animals subjected to neonatal interventions.

show abstract

“…Similarly, Noschang et al [38] found that females subjected to an EH paradigm showed impairments in spatial learning, while this effect was not observed in [11, [41][42][43][44]. However, the exact mechanism by which this plasticity occurs remains unclear.…”

Section: Gender As An Important Factormentioning

confidence: 99%

Rodent models of early environment effects on offspring development and susceptibility to neurological diseases in adulthood

Coutellier

2012

Translational Neuroscience

View full text Add to dashboard Cite

Rodent Models of eaRly envIRonMent effects on offspRIng developMent and susceptIbIlIty to neuRologIcal dIseases In adulthood abstractEvents early in life can program brain for a pattern of neuroendocrine and behavioral responses in later life. This mechanism is named "developmental phenotypic plasticity". Experimental evidences from rodents show that early experiences influence long-term development of behavioral, neuroendocrine and cognitive functions. While some neonatal conditions lead to positive outcomes, offspring might also display neurological dysfunctions in adulthood in case of adverse conditions during the early development. Different factors have been suggested to mediate the effects of neonatal conditions on offspring development but their exact contribution as well as their interaction still needs to be clarified. Studies based on rodents have been developed to model the longterm effects of early environmental conditions on the developing brain. These studies highlight importance of maternal behavior in mediating the effects of early environmental conditions on the offspring. However, other studies suggest that aside from the level of maternal care, other factors (gender, neonatal glucocorticoid levels) contribute to the adjustment of offspring phenotype to early environmental cues. Altogether, rodentsbased evidence suggests that developmental plasticity is a very complex phenomenon mediated by multiple factors that interact one to each other. Ultimately, the goal is to understand how early life events can lead to advantageous phenotype in adult life, or, on the contrary, can predispose individuals to psychopathologies such as depression or anxiety.

show abstract

Neonatal Handling Impairs Spatial Memory and Leads to Altered Nitric Oxide Production and DNA Breaks in A Sex Specific Manner

Cited by 23 publications

References 50 publications

Early life manipulations alter learning and memory in rats

Early life manipulations alter learning and memory in rats

Mitochondrial and Oxidative Stress Aspects in Hippocampus of Rats Submitted to Dietary n-3 Polyunsaturated Fatty Acid Deficiency After Exposure to Early Stress

Rodent models of early environment effects on offspring development and susceptibility to neurological diseases in adulthood

Contact Info

Product

Resources

About