NEONATAL HYPERTRIGLYCERIDEMIA A New Index of Antepartum‐Intrapartum Fetal Stress?

Abstract

The 95th percentile value of cord serum triglyceride concentration in 82 consecutively live born infants was found to be 0.79 mmol/l. This level was arbitrarily used to define neonatal hypertriglyceridemia. A comparison between 78 normotriglyceridemic and 61 hypertriglyceridemic newborn infants showed a significant association between elevated cord serum triglyceride concentration and insufficiency of the placenta, fetal bradycardia, meconium-stained amniotic fluid and one-minute Apgar score less than or equal to 7. A significantly (p less than 0.001) greater number of infants with one or several of these four factors, indicating antepartum and/or intrapartum fetal stress were found to be hypertriglyceridemic at birth. This finding suggests that estimation of cord serum triglyceride which is easy and inexpensive might be of value for a more complete evaluation of the newborn infant, and can serve as a supplement to the Apgar Score system.

Assay of neonatal cord blood lipid levels and its correlation with neonatal gestational age, gender and birth weight: a single center experience

“…This was in unison with few other studies including Anderson et al and Tsang et al which showed no significant changes in the cord blood lipid profile in terms of gender. 12,13 But contrasting results were noted in studies by Hardell et al, Zhao et al, Simmi Kharb et al and Badiee Z et al who noted significantly higher total cholesterol and HDL levels in their study group. [14][15][16][17] Higher and statistically significant values of total cholesterol, LDL and triglyceride levels were noted in our low birth weight (LBW) study group.…”

High-Density Lipoprotein Subclass Distribution And Human Cord Blood Lipid Levels

“…Several investigators have shown that prenatal and perinatal complications can influence CB lipid levels (12)(13)(14)(15)(16)(17)(18)(19)(20). It is well known that prematurity (gestational age less than 37 wk) is associated with elevated TC and low TG (1 2, 14, 17-19, 2 1) and that TC is elevated in infants of diabetic mothers (19,35,36).…”

“…Of the total CB plasmas examined, 154 samples with plasma volume of 2 ml or more were selected for determination of HDL-cholesterol and for evaluation by gradient polyacrylamide gel electrophoresis. Since prematurity and perinatal complications have been shown to be associated with elevated CB lipid levels (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), emphasis was placed on inclusion of infants with pre-and perinatal complications or lipid levels above 100 mg/dl.…”

“…(1 1) and was deficient in (HDL3a)gge, the major peak in adult HDL. Several reports indicate that prematurity and pre-and perinatal complications elevate the cholesterol and TG levels of cord blood (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). However, little is known about the effect of elevated lipid levels on the HDL subclass distribution in the newborn.…”

Correlation of maternal lipid profile with newborn’s lipid profile

“…[1][2][3] Concentrations of the cord blood lipoprotein subtypes are influenced by fetal malnutrition and prematurity. [4][5][6] High concentrations of triglyceride-rich lipoproteins, and apolipoprotein B in infants with a low gestational age; and increase of Apo c-1 rich in high-density lipoprotein (HDL) with low birth weight are potential risk factors for cardiovascular disease in the future.…”