Neonatal meningitis according to the microbiological diagnosis: a decade of experience in a tertiary center

Bentlin, Maria Regina; Ferreira, Gabriel Luís; Rugolo, Lígia Maria Suppo de Souza; Silva, Geraldo Henrique Soares; Mondelli, Alessandro Lia; Júnior, Antonio Rugolo

doi:10.1590/s0004-282x2010000600010

Cited by 18 publications

(24 citation statements)

References 26 publications

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“…The prevalence of meningitis in our NICU was 0.7% which is comparable to study by Bentlin et al (0.6%). 17 The study from Africa and Asia reported incidence of meningitis ranging from 0.8 to 6.1 per 1000 live births. 18 Neonatal risk factors observed in our study were low birth weight (87.7%), prematurity (75%), birth asphyxia (20.1%), mechanical ventilation (17.3%).…”

Section: Discussionmentioning

confidence: 99%

“…Bentlin et al have also reported (21 out of 22) late onset of neonatal meningitis cases. 17 These low rates of positive culture in early infection may be due to hemodynamic instability which delays lumbar puncture and use of antibiotics before the lumbar puncture which interfere with bacterial growth. 34 The Out of the 20 isolates of K. pneumoniae, 9 (45%) isolates were ESBL producers.…”

Section: Discussionmentioning

confidence: 99%

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A study of infections in neonatal intensive care unit at a tertiary care hospital

Ingale

Kongre

Bharadwaj

2017

Int J Contemp Pediatr

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Background: As infection is a major cause of morbidity and mortality in neonates, early diagnosis and prompt treatment can prevent its serious consequences. The present study was conducted to determine the prevalence of infections in neonatal intensive care unit (NICU) of a tertiary care hospital and to study their risk factors, causative organisms and antimicrobial susceptibility pattern.Methods: Appropriate samples were collected from all neonates with clinical signs and symptoms of infections. Isolation of microorganisms, their identification and antimicrobial susceptibility was done according to standard microbiological techniques.Results: Among 1210 neonates admitted in the NICU, 393 (32.4%) were clinically suspected infections. The prevalence of Septicemia, Pneumonia, and Meningitis were 6%, 1.5%, 0.7% respectively. The predominant organisms causing neonatal infection were Gram negative bacteria followed by fungi and Gram positive bacteria. Among Gram negative bacteria, the antimicrobial resistance was highest for third generation Cephalosporins [Ceftazidime (81.1%), Cefotaxime (60.3%)]. In Gram positive bacteria highest resistance was observed for Penicillin and Ampicillin (91.3%). Methicillin resistance was observed in 91.6% of Coagulase negative Staphylococci (CoNS). All isolates of Candida parapsilosis were sensitive to Fluconazole, Voriconazole but resistant to Amphotericin B. Predominant risk factors were low birth weight (87.7%) and prematurity (75%). Maternal risk factors were pregnancy induced hypertension (13.4%) and premature rupture of membranes (PROM) (10.1%). The case fatality rate was 20.7%.Conclusions: There is a need of strict infection control measures and rational antibiotic policy to reduce the economic burden of hospital and community due to neonatal infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A study of infections in neonatal intensive care unit at a tertiary care hospital

Ingale

Kongre

Bharadwaj

2017

Int J Contemp Pediatr

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“…El aumento se relacionaría con una mejora en el diagnóstico, mayor complejidad asistencial y mejor capacidad resolutiva. Sin embargo, se encuentra dentro del rango esperado a nivel internacional (3,10,13,14) .…”

Section: Discussionunclassified

“…La tasa de letalidad fue menor a la esperada para países en desarrollo (15-30%) y es concordante con países desarrollados (<10%) (5,9,14) , siendo mayor en casos de MN temprana. Esto difiere de estudios españoles y franceses donde se encontraron tasas de letalidad de 2,3 y 2 veces mayor en MN tardía, teniendo ambos mayores tamaños poblacionales (10,17) .…”

Section: Discussionunclassified

Meningitis neonatal en un hospital general de Lima, Perú, 2008 al 2015

Lewis

Schweig

Guillén–Pinto

et al. 2017

Rev Peru Med Exp Salud Publica

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NEONATAL MENINGITIS IN A GENERAL HOSPITAL IN LIMA, PERU, 2008 TO 2015 ABSTRACTAiming at describing the incidence, clinical characteristics and factors associated with neonatal meningitis (NM), a case series study was conducted from 2008 to 2015, where 53 neonates, 10 with early onset NM and 43 with late onset were included. An incidence of 1.5 per thousand live births and a lethality of 3.8% were found. The associated factors were peripartum fever, urinary tract infection and chorioamnionitis (P < 0.05). Frequent symptoms were fever (84.9%), hypotonia (77.4%) and hypoactivity (73.6%). In the cerebrospinal fluid (CSF), the cases of early NM presented a median of 330 leukocytes/µl and 29 mg/dl of glucose, and the cases of late NM presented 170 leukocytes/µl and 32 mg/dl of glucose. The most common bacteria were Listeria monocytogenes (16.9%) and negative coagulase staphylococcus (11.3%). In conclusion, the incidence was high compared to other studies and the associated factors were the expected.

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“…Thus, ataxic mice had histological changes characteristic of Gram-negative bacillary meningoencephalitis. 21 Fluorescence immunohistochemistry and confocal microscopy revealed that the severe histological changes in the ataxic Nramp1 þ/þ mice were associated with areas of bacterial infection. Salmonella was observed in the olfactory bulb ( Figure 9A), periventricular areas ( Figure 9B), ventricles ( Figure 9, C and D), and meninges ( Figure 9, E and F).…”

Section: Pathology Correlates With Neurological Signs Of Ataxia In Nrmentioning

confidence: 96%

Salmonella Meningitis Associated with Monocyte Infiltration in Mice

Bauler

Starr

Nagy

et al. 2017

The American Journal of Pathology

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In the current study, we examined the ability of Salmonella enterica serovar Typhimurium to infect the central nervous system and cause meningitis following the natural route of infection in mice. C57BL/6J mice are extremely susceptible to systemic infection by Salmonella Typhimurium because of loss-of-function mutations in Nramp1 (SLC11A1), a phagosomal membrane protein that controls iron export from vacuoles and inhibits Salmonella growth in macrophages. Therefore, we assessed the ability of Salmonella to disseminate to the central nervous system (CNS) after oral infection in C57BL/6J mice expressing either wild-type (resistant) or mutant (susceptible) alleles of Nramp1. In both strains, oral infection resulted in focal meningitis and ventriculitis with recruitment of inflammatory monocytes to the CNS. In susceptible Nramp1 mice, there was a direct correlation between bacteremia and the number of bacteria in the brain, which was not observed in resistant Nramp1 mice. A small percentage of Nramp1 mice developed severe ataxia, which was associated with high bacterial loads in the CNS as well as clear histopathology of necrotizing vasculitis and hemorrhage in the brain. Thus, Nramp1 is not essential for Salmonella entry into the CNS or neuroinflammation, but may influence the mechanisms of CNS entry as well as the severity of meningitis.

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Neonatal meningitis according to the microbiological diagnosis: a decade of experience in a tertiary center

Cited by 18 publications

References 26 publications

A study of infections in neonatal intensive care unit at a tertiary care hospital

A study of infections in neonatal intensive care unit at a tertiary care hospital

Meningitis neonatal en un hospital general de Lima, Perú, 2008 al 2015

Salmonella Meningitis Associated with Monocyte Infiltration in Mice

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