Neonatal monocular enucleation-induced cross-modal effects observed in the cortex of adult rat

Toldi, József; Rojik, I.; Fehér, O.

doi:10.1016/0306-4522(94)90318-2

Cited by 58 publications

(25 citation statements)

References 38 publications

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“…Moreover, auditory activation of the visual cortex was reported in enucleated hamsters (Izraeli et al, 2002), rats (Piché et al, 2007), opossum (Kahn and Krubitzer, 2002) and cats (Kahn and Krubitzer, 2002;Yaka et al, 2000Yaka et al, , 1999. In addition, significant somatosensory activity was shown in the visual cortex of enucleated rats (Toldi et al 1988(Toldi et al , 1994b and there is evidence for a significant somatosensory input to the dorsal lateral geniculate nucleus of similar extent in enucleated and eyeless mice (Asanuma and Stanfield, 1990). The present data shows that crossmodal auditory and/or somatosensory activations of the visual cortex in anophthalmic mice do not prevent a significant size reduction of the primary visual cortex.…”

Section: 2mentioning

confidence: 92%

Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

et al. 2014

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Section: 2mentioning

confidence: 92%

Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

et al. 2014

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“…This was taken to mean greater synaptic activity in the early blind, possibly reflecting incomplete developmental pruning of synapses. Correspondingly, neonatal visual deprivation in rats and monkeys results in the appearance of somatosensory responsiveness in extrastriate occipital cortex (Hyvärinen, Carlson, & Hyvärinen, 1981;Toldi, Rojik, & Feher, 1994). Prenatal enucleation of monkeys at an early stage results in shrinkage of V1, with consequent redirection of cortical projections destined for V1 to adjacent extrastriate cortex and substantial expansion of ventral extrastriate areas (Barone, Batardière, Dehay, Berland, & Kennedy, 1996;Barone et al, 1997).…”

Section: Involvement Of Visual Cortical Areas In Nonvisual Perceptionmentioning

confidence: 95%

Visual cortical activity during tactile perception in the sighted and the visually deprived

Sathian

2005

Developmental Psychobiology

155

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This article reviews studies demonstrating activity in visual cortex during tactile perception in sighted participants as well as in those who have experienced visual deprivation of varying duration. This field has been very active over the last few years, with the result that a number of exciting findings have emerged, but a unifying framework is still lacking. The first section of this article deals with investigations revealing that visual cortical activity is regularly associated with the neural processing of tactile inputs in normally sighted individuals. Next, the possible reasons underlying such visual cortical recruitment are considered. The focus then shifts to the effects of visual deprivation, examining the involvement of visual cortex in sensory and language processing in the early and late blind. The final section gives an account of studies suggesting that a remarkable degree of plasticity can be observed even after quite short-lasting visual deprivation. Overall, it appears that the nature of visual cortical activity during nonvisual tasks in the sighted can be influenced by late-onset blindness and even by brief interruptions of visual input; however, the relevant neural plasticity seems to considerably more exuberant if vision is lost very early in life or was never present, which suggests that there is a critical period for the maximal expression of such plasticity.

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“…In experimental animals, visual deprivation results in enhanced axonal sprouting between the deprived visual area and surrounding auditory and somatosensory areas (52,(54)(55)(56). In addition to anatomic change, cross-modal plasticity also involves homeostatic plasticity mechanisms that drive alterations in synaptic strength.…”

Section: Binocular Visual Deprivation Alters Intra-and Internetworkmentioning

confidence: 99%

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Kraft

Mitra

Bauer

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Decades of work in experimental animals has established the importance of visual experience during critical periods for the development of normal sensory-evoked responses in the visual cortex. However, much less is known concerning the impact of early visual experience on the systems-level organization of spontaneous activity. Human resting-state fMRI has revealed that infraslow fluctuations in spontaneous activity are organized into stereotyped spatiotemporal patterns across the entire brain. Furthermore, the organization of spontaneous infraslow activity (ISA) is plastic in that it can be modulated by learning and experience, suggesting heightened sensitivity to change during critical periods. Here we used wide-field optical intrinsic signal imaging in mice to examine whole-cortex spontaneous ISA patterns. Using monocular or binocular visual deprivation, we examined the effects of critical period visual experience on the development of ISA correlation and latency patterns within and across cortical resting-state networks. Visual modification with monocular lid suturing reduced correlation between left and right cortices (homotopic correlation) within the visual network, but had little effect on internetwork correlation. In contrast, visual deprivation with binocular lid suturing resulted in increased visual homotopic correlation and increased anti-correlation between the visual network and several extravisual networks, suggesting cross-modal plasticity. These network-level changes were markedly attenuated in mice with genetic deletion of Arc, a gene known to be critical for activity-dependent synaptic plasticity. Taken together, our results suggest that critical period visual experience induces global changes in spontaneous ISA relationships, both within the visual network and across networks, through an Arc-dependent mechanism.infraslow activity | functional connectivity | visual critical period | activity-regulated cytoskeleton-associated protein

show abstract

Neonatal monocular enucleation-induced cross-modal effects observed in the cortex of adult rat

Cited by 58 publications

References 38 publications

Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

Visual cortical activity during tactile perception in the sighted and the visually deprived

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

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