Neonatal Necrotizing Enterocolitis

Bell, Martin; Ternberg, Jessie L.; Feigin, Ralph D.; Keating, James P.; Marshall, Richard; Barton, Leslie L.; Brotherton, Thomas

doi:10.1097/00000658-197801000-00001

Cited by 2,983 publications

(878 citation statements)

References 39 publications

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“…Perinatal outcomes included GA at birth, fetal gender, birth weight, presence or absence of growth restriction with birth weight <3%, presence or absence of respiratory distress syndrome (RDS), bronchopulmonary dysplasia, intraventricular hemorrhage (IVH), periventricular leukomalacia, necrotizing enterocolitis, retinopathy of prematurity (ROP), neonatal sepsis, perinatal death and neonatal stay in the Neonatal Intensive Care Unit (NICU) as defined by accepted international classifications. [19][20][21] Adverse neonatal outcomes were additionally combined in a moderate morbidity index defined as one or more of the following outcomes: RDS, IVH grades 1 or 2, ROP grades 1 or 2 or neonatal sepsis and a severe morbidity index defined as one or more of IVH grades 3 or 4, periventricular leukomalacia, necrotizing enterocolitis, ROP grades 3 or 4, bronchopulmonary dysplasia or perinatal death. These morbidity indices were designed to address the clinical impact of a neonatal outcome that either has a major effect on infant health (severe morbidity index), or a minor effect with less impact on long-term health (moderate morbidity index).…”

Section: Methodsmentioning

confidence: 99%

Neonatal outcomes are associated with latency after preterm premature rupture of membranes

et al. 2012

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Objective: To determine factors associated with latency time to birth after preterm premature rupture of membranes (PPROM) and the impact on neonatal outcomes.Study Design: Data on singleton pregnancies with PPROM (n ¼ 1535 infants) were prospectively collected in a computerized perinatal/neonatal database at a tertiary care perinatal center. Latency was characterized as p72h versus >72 h after PPROM.Result: The percentage of women with latency to birth >72 h decreased from 67% in very preterm (gestational age (GA) 25 to 28 weeks) to 10% in late preterm women (GA 33 to 36 weeks). PPROM women with latency p72 h were more likely to have pregnancy-induced hypertension and birth weight <3%; PPROM women with latency >72 h were more likely to have received steroids and develop clinical chorioamnionitis. PPROM <32 weeks GA with latency p72 h was associated with a two-fold higher incidence of severe neonatal morbidity, while PPROM between 29 to 34 weeks GA and latency p72 h was associated with a higher incidence of moderate neonatal morbidity. Conclusion:A latency period >72 h was associated with a decreased incidence of adverse neonatal outcomes up to 32 weeks GA for severe and 34 weeks GA for moderate morbidity indices.

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Section: Methodsmentioning

confidence: 99%

Neonatal outcomes are associated with latency after preterm premature rupture of membranes

et al. 2012

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“…Detailed information was collected for specific conditions related to prematurity, including NEC (Bell's stage II or greater), 28 sepsis (confirmed by culture), intraventricular hemorrhage, bronchopulmonary dysplasia and retinopathy of prematurity (ROP). Investigators documented the occurrence and clinical outcome of each event.…”

Section: Growth and Feeding Tolerancementioning

confidence: 99%

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

et al. 2011

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Objective: Dietary carotenoids (lutein, lycopene and b-carotene) may be important in preventing or ameliorating prematurity complications. Little is known about carotenoid status or effects of supplementation.Study Design: This randomized controlled multicenter trial compared plasma carotenoid levels among preterm infants (n ¼ 203, <33 weeks gestational age) fed diets with and without added lutein, lycopene and b-carotene with human milk (HM)-fed term infants. We assessed safety and health.Result: Plasma carotenoid levels were higher in the supplemented group at all time points (P<0.0001) and were similar to those of term HM-fed infants. Supplemented infants had lower plasma C-reactive protein (P<0.001). Plasma lutein levels correlated with the full field electroretinogram-saturated response amplitude in rod photoreceptors (r ¼ 0.361, P ¼ 0.05). The supplemented group also showed greater rod photoreceptor sensitivity (least squares means 6.1 vs 4.1; P<0.05). Conclusion:Carotenoid supplementation for preterm infants raises plasma concentrations to those observed in HM-fed term infants. Carotenoid supplementation may decrease inflammation. Our results point to protective effects of lutein on preterm retina health and maturation.

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“…In this study we collected data related to IVH, germinal matrix haemorrhage (GMH), periventricular leukomalacia (PVL) and ventriculomegaly (mild 0.5-1cm, moderate 1.0-1.5cm, severe >1.5cm). The diagnosis of NEC was made if the baby had modified Bell's stage 2 or 3 12 .…”

Section: Objectivesmentioning

confidence: 99%

Short term outcome, complications and average direct cost in managing extremely low birth weight infants in a tertiary care centre in Sri Lanka

Nelumdeniya¹,

Silva²,

Nanayakkara³

et al. 2012

Sri Lanka J Child Health

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Neonatal Necrotizing Enterocolitis

Cited by 2,983 publications

References 39 publications

Neonatal outcomes are associated with latency after preterm premature rupture of membranes

Neonatal outcomes are associated with latency after preterm premature rupture of membranes

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

Short term outcome, complications and average direct cost in managing extremely low birth weight infants in a tertiary care centre in Sri Lanka

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