Neonatal outcomes in in vitro fertilization (IVF) pregnancies

Buchori, Muhammad; Patria, Suryono Yudha; Wibowo, Tunjung; Hanoum, Ita Fauzia

doi:10.19106/jmedsci005002201805

Cited by 2 publications

(3 citation statements)

References 21 publications

(31 reference statements)

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“…1,2 The number of neonates born through this process continues to increase, with an estimated 3-5 million IVF neonates worldwide since the first successful IVF and embryo transfer was reported in 1978. 3,4 In accordance with reports of success, IVF also poses potential risks for both mother and baby. 5 In most ARTs, higher numbers of embryos are transferred to the uterus, resulting in multiple pregnancies.…”

supporting

confidence: 64%

“…In a comparison of natural conception and IVF, multiple pregnancies were higher in IVF. 4 Another study found that mothers who underwent ART conception had a 54 times higher chance of multiple pregnancies. 22 In order to reduce the incidence of multiple pregnancies while improving perinatal outcomes, many studies have focused on reduction of the number of embryos transferred into the uterus at one time.…”

Section: Discussionmentioning

confidence: 99%

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Neonatal outcomes from in vitro fertilization-conceived pregnancies

Imanadhia,

Kaban,

Iskandar

et al. 2023

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Background In vitro fertilization (IVF) shows potential to improve pregnancy success, especially for infertile couples. This technique has some risks for neonates in the perinatal period and may affect their future health. Objective To investigate the characteristics and clinical outcomes of neonates from IVF-conceived pregnancies. Methods This retrospective study was conducted in neonates from IVF-conceived pregnancies from January to December 2021 at Bunda Women’s and Children’s Hospital, Jakarta. We gathered data from medical records about maternal age and morbidity, gravidity, gestational age, method of delivery, multiple gestation, also neonates’ significant profiles like prematurity, birth weight, Apgar score, and morbidities in perinatal period. We would like to investigate the characteristics and clinical outcomes of neonates born from IVF-conceived pregnancies program. Results There were 361 neonates whose mothers underwent IVF included in this study. Most mothers were ?35 years (70.9%) and on their first pregnancy (69.2%). Maternal complicating factors were premature contractions (16.6%), premature rupture of membranes (8.3%), and twin pregnancy (31.5%). About 98.6% of deliveries were performed by caesarean section and from IVF-conceived pregnancies program most 61.2% neonates were born at full term gestation (61.2%). Preterm deliveries occurred at a mean gestational age of 34.4 (SD 2.4) weeks. Subjects’ mean birth weight was 2,800.2 (SD 640.3) grams, with 26.3% in the low-birth-weight category. Most neonates (93.0%) were appropriate weight for gestational age and had good Apgar scores in the first minute (92.2%) and fifth minute (99.7%). However, 24.3% of neonates needed intensive care (NICU) with morbidities. The longest length of NICU stay was 100 days, with mortality of 7.9% of NICU-treated infants. Conclusion In our setting, most neonates from the IVF program were born with good outcomes, although preterm birth rate, low birth weight, need for NICU care, and mortality rate were quite high. Further study is needed to evaluate long-term outcomes of IVF neonates.

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supporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Neonatal outcomes from in vitro fertilization-conceived pregnancies

Imanadhia,

Kaban,

Iskandar

et al. 2023

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“…Studi lain di Indonesia menunjukkan persentase kelahiran hidup sebesar 19,8% pada IVF. 4,5 their chances of becoming pregnant are reduced. The follicle-stimulating hormone (FSH Tujuan utama IVF adalah untuk mencapai potensi implantasi maksimum.…”

Section: Pendahuluanunclassified

Hubungan Anti-Mullerian Hormone (AMH) pada Long dan Short Protocol Terhadap Fertilization Rate Pasien In Vitro Fertilization (IVF)

Wahid

Armawan

Djuwantono

2021

Obgynia

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Abstrak Tujuan: Untuk mengevaluasi pengaruh kadar anti-mullerian hormone (AMH) dengan fertilization rate (FR) dan menilai perbedaan pengaruh jenis protokol (long protocol (LP) dan short protocol (SP)) pada tiap tingkat cadangan ovarium terhadap FR pada pasien in vitro fertilization (IVF) dengan Intracytoplasmic Sperm Injection. Metode: Data sekunder dari rekam medis pasien yang menjalani IVF di Aster Fertility Clinic Rumah Sakit Umum Pendidikan dr. Hasan Sadikin pada tahun 2016-2020 dan Bandung Fertility Centre Rumah Sakit Ibu Anak Limijati pada tahun 2018-2019. Penelitian ini analitik observational dengan metode Cohort retrospektif. Hubungan antara dua data kategorik diuji dengan uji chi-square dan uji Kruskal-Wallis digunakan pada data numerik dengan distribusi yang tidak rata pada lebih dari 2 kelompok, Hasil: Hasil data diperoleh nilai rerata kadar AMH secara keseluruhan adalah 3.30 ng/ml dengan rerata capaian FR sebesar 71.97%. Berdasarkan metode IVF yang dipilih, mayoritas pasien menjalani pengobatan SP 54.4% (rerata FR 72.80%) dibandingkan dengan LP 45.6% (rerata FR 70.97%). Tidak ditemukan hubungan yang bermakna antara kadar AMH dengan FR, dinyatakan dengan nilai p=0.977. Kadar AMH terhadap FR bila dipisahkan menurut protokol terapi yang diberikan tidak menunjukkan perbedaan yang bermakna pada masing-masing protokol (LP p=0,763; SP p=0,843). Mengenai hubungan antara protokol IVF dengan FR juga tidak diperoleh perbedaan yang signifikan secara statistik dengan nilai p=0,27 (RR 1.17 (0.62-2.15); CI 95%). Penggobatan menggunakan LP (p=0,770) maupun SP (p=0.845) tidak memberikan pengaruh yang bermakna terhadap FR pada setiap kategori AMH. Kesimpulan: Tidak ada pengaruh kadar AMH dan protokol terapi terhadap FR. Kata kunci : In Vitro Fertilization, Fertilization Rate, Anti-Mullerian Hormone, Protokol Stimulasi Ovarium

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Neonatal outcomes in in vitro fertilization (IVF) pregnancies

Cited by 2 publications

References 21 publications

Neonatal outcomes from in vitro fertilization-conceived pregnancies

Neonatal outcomes from in vitro fertilization-conceived pregnancies

Hubungan Anti-Mullerian Hormone (AMH) pada Long dan Short Protocol Terhadap Fertilization Rate Pasien In Vitro Fertilization (IVF)

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