Neonatal overfeeding reduces estradiol plasma levels and disrupts noradrenergic-kisspeptin-GnRH pathway and fertility in adult female rats

Stopa, Larissa Rugila S.; Souza, Camila F. de; Martins, Andressa Busetti; Lopes, Gabriela Mendicelli; Costa, Nathalia Orlandini; Gerardin, Daniela Cristina Ceccatto; Carvalho, Giovana Gomes de; Zaia, Dimas Augusto Morozin; Zaia, Cássia Thaïs Bussamra Vieira; Uchôa, Ernane Torres; Leite, Cristiane Mota

doi:10.1016/j.mce.2020.111147

Cited by 12 publications

(12 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, there are other central modifications that affect the hormonal axis and contribute to metabolic disorders in adulthood. Adaptive changes in the hypothalamus–pituitary–adrenal (HPA) axis have been reported [ 28 ], affecting stress responses; in the hypothalamus–pituitary–thyroid (HPT) axis [ 29 ], impacting energy expenditure; and in the reproductive axis [ 30 ], causing reproductive disorders.…”

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

“…In addition to central dysfunction, SL offspring exhibit several peripheral changes involved in their metabolic profile. The early energy and fat overload promoted by the SL model [ 17 ] has been involved in many metabolic disorders by affecting the postnatal development and function of glands such as the pancreas, adrenal, adipose tissue, thyroid, and gonads and metabolic tissues such as liver [ 17 , 29 , 30 , 39 , 40 , 41 ]. These hormonal changes can act as an imprinting factor or a mechanism of developmental adaptations in metabolic programming models.…”

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

“…On the other hand, female SL offspring exhibit controversial changes at puberty. It has been described as normal [ 67 ], early [ 30 ], or delayed vaginal opening [ 68 ]. Reinforcing the suggestions of early puberty in SL females, they show an early first estrus compared to control animals [ 30 ].…”

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

“…It has been described as normal [ 67 ], early [ 30 ], or delayed vaginal opening [ 68 ]. Reinforcing the suggestions of early puberty in SL females, they show an early first estrus compared to control animals [ 30 ]. At puberty onset, SL female offspring also have higher levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [ 67 ] than normal litters.…”

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

“…In adulthood, despite the absence of changes in the serum LH and progesterone levels in SL females, they exhibit reduced hypothalamic gonadotropin releasing hormone (GnRH) expression, reduced kisspeptin expression, and lower serum estradiol levels [ 67 ]. This disruption in the noradrenergic–kisspeptin–GnRH pathway seems to be involved in the reproductive disorders of SL female offspring [ 30 ].…”

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

See 4 more Smart Citations

Litter Size Reduction as a Model of Overfeeding during Lactation and Its Consequences for the Development of Metabolic Diseases in the Offspring

2022

View full text Add to dashboard Cite

Overfeeding during lactation has a deleterious impact on the baby’s health throughout life. In humans, early overnutrition has been associated with higher susceptibility to obesity and metabolic disorders in childhood and adulthood. In rodents, using a rodent litter size reduction model (small litter) to mimic early overfeeding, the same metabolic profile has been described. Therefore, the rodent small litter model is an efficient tool to investigate the adaptive mechanisms involved in obesogenesis. Besides central and metabolic dysfunctions, studies have pointed to the contribution of the endocrine system to the small litter phenotype. Hormones, especially leptin, insulin, and adrenal hormones, have been associated with satiety, glucose homeostasis, and adipogenesis, while hypothyroidism impairs energy metabolism, favoring obesity. Behavioral modifications, hepatic metabolism changes, and reproductive dysfunctions have also been reported. In this review, we update these findings, highlighting the interaction of early nutrition and the adaptive features of the endocrine system. We also report the sex-related differences and epigenetic mechanisms. This model highlights the intense plasticity during lactation triggering many adaptive responses, which are the basis of the developmental origins of health and disease (DOHaD) concept. Our review demonstrates the complexity of the adaptive mechanisms involved in the obesity phenotype promoted by early overnutrition, reinforcing the necessity of adequate nutritional habits during lactation.

show abstract

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

Section: The Litter Size Reduction Model: Short- and Long-term Effectsmentioning

confidence: 99%

See 3 more Smart Citations

Litter Size Reduction as a Model of Overfeeding during Lactation and Its Consequences for the Development of Metabolic Diseases in the Offspring

2022

View full text Add to dashboard Cite

show abstract

Neonatal overnutrition, but not neonatal undernutrition, disrupts CCK-induced hypophagia and neuron activation of the nucleus of the solitary tract and paraventricular nucleus of hypothalamus of male Wistar rats

Wunderlich¹,

Martins²,

Souza³

et al. 2023

Brain Research Bulletin

View full text Add to dashboard Cite

Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells

Lei

Huang

et al. 2022

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

Neonatal overfeeding reduces estradiol plasma levels and disrupts noradrenergic-kisspeptin-GnRH pathway and fertility in adult female rats

Cited by 12 publications

References 52 publications

Litter Size Reduction as a Model of Overfeeding during Lactation and Its Consequences for the Development of Metabolic Diseases in the Offspring

Litter Size Reduction as a Model of Overfeeding during Lactation and Its Consequences for the Development of Metabolic Diseases in the Offspring

Neonatal overnutrition, but not neonatal undernutrition, disrupts CCK-induced hypophagia and neuron activation of the nucleus of the solitary tract and paraventricular nucleus of hypothalamus of male Wistar rats

Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells

Contact Info

Product

Resources

About