Neonatal Polycythemia and Hyperviscosity

Black, Virginia D.; Lubchenco, Lula O.

doi:10.1016/s0031-3955(16)34251-1

Cited by 35 publications

(19 citation statements)

References 58 publications

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“…Hyperviscosity may, therefore, impede blood flow to various organs, compromise their oxygen supply, and result in organ failure or damage (2)(3)(4)(5)(6). In particular, hyperviscosity increases the risk of pulmonary hypertension (6), renal failure (2), necrotizing enterocolitis (7), cerebral ischemia (4), intracranial hemorrhage (8), and developmental retardation (9).…”

mentioning

confidence: 99%

“…In artificial tubes as well as in blood vessels with diameters of less than 500 pm, both the hematocrit (Fahraeus effect) and the blood viscosity (Fahraeus-Lindqvist effect) decrease with decreasing diameter (1 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. This has been attributed to the migration of RBC to the tube center, thereby creating a cell-poor plasma layer on the wall and a cell-rich central core (17)(18)(19)(20)(21)(22).…”

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confidence: 99%

“…Studies using artificial tubes have shown that the viscosity of adult blood with a hematocrit of 0.40 111 (= 40%) decreases by about 40% as the tube diameter is decreased from 500 to 50 pm (1 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. At higher hematocrit, the viscosity reduction may be 60% or more (1 8, 19).…”

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confidence: 99%

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Viscosity Reduction of Red Blood Cells from Preterm and Full-Term Neonates and Adults in Narrow Tubes (Fahraeus-Lindqvist Effect)

Zilow

Linderkamp

1989

Pediatr Res

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ABSTRACT. In artificial tubes as well as in blood vessels with diameters less than 500 pm, blood viscosity decreases with decreasing diameter (Fahraeus-Lindqvist effect). Our study measured viscosity of red blood cells (RBC) from 10 preterm infants, 10 term neonates, and 10 adults by means of a capillary viscometer. RBC were suspended in buffer at hematocrits of 0.20,0.40, and 0.60 111 (1.00 111 = 100%).

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Viscosity Reduction of Red Blood Cells from Preterm and Full-Term Neonates and Adults in Narrow Tubes (Fahraeus-Lindqvist Effect)

Zilow

Linderkamp

1989

Pediatr Res

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“…Ao se observar a existência de uma associação entre valores médios de velocidade de FSC na ACA com a presença de policitemia, corroborou-se com resultados semelhantes observados por vários outros autores 19,26,27 , que também descreveram diminuição significativa dos valores de fluxo cerebral em RN com hiperviscosidade sanguínea. Os fatores etiológicos mais importantes para o seu desencadeamento provêm, em grande parte, da insuficiência placentária e de quadros de hipoxemia intra-uterina e o consequente aumento de eritropoiese fetal.…”

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Velocimetria Doppler no período neonatal em recém-nascidos a termo pequenos para idade gestacional

Muniz

Netto

Gonçalves

2003

Arq. Neuro-Psiquiatr.

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RESUMO -Este estudo teve como objetivo avaliar o fluxo sanguíneo cerebral em recém-nascidos a termo pequenos para idade gestacional, utilizando ultra-sonografia Doppler craniana ao nascimento. O estudo foi desenvolvido no CAISM/UNICAMP (Centro de Saúde Terciário para Mulheres). Foram selecionados sessenta recém-nascidos e divididos em 2 grupos: 36 adequados para idade gestacional (AIG) e 24 pequenos para idade gestacional (PIG). Foi realizada a avaliação de ultra-sonografia Doppler craniana nos grupos, entre 24-48 horas após o nascimento. A velocidade de fluxo sanguíneo cerebral foi menor no grupo PIG na artéria cerebral anterior (ACA). As medidas Doppler foram estatisticamente diferentes entre os grupos apenas para valores relacionados à velocidade de fluxo de pico sistólico (VFPS) e velocidade de fluxo médio (VFM) na ACA. Não houve diferenças significantes para nenhum dos parâmetros avaliados de velocidade de fluxo na artéria cerebral média (ACM). Concluiu-se que recém-nascidos PIG apresentaram VFPS e VFM significativamente menores apenas na ACA. A adequação peso/ idade gestacional, presença de policitemia neonatal e valores de pressão arterial média estiveram estatisticamente associados a VFM na ACA. A presença de sofrimento fetal, valores de pressão arterial média e hábito de fumar durante a gestação estiveram estatisticamente associados a VFM na ACM.PALAVRAS-CHAVE: Doppler-ultra-sonografia craniana, desnutrição intra-uterina, recém-nascido.Neonatal Doppler velocimetry in full term small-for Neonatal Doppler velocimetry in full term small-for Neonatal Doppler velocimetry in full term small-for Neonatal Doppler velocimetry in full term small-for Neonatal Doppler velocimetry in full term small-for-gestational age newborns -gestational age newborns -gestational age newborns -gestational age newborns -gestational age newbornsABSTRACT -This study aimed to evaluate the cerebral blood flow of full term small-for-gestational age newborns, using cranial ultrasound Doppler at birth. This study was performed at CAISM/UNICAMP (Tertiary Health Center for Women). Sixty term newborns were selected and divided in two groups: appropriate-for-gestational age (AGA) (36 neonates) and small-for-gestational age (SGA) (24 neonates). Cranial ultrasound Doppler evaluation was performed on both groups, between 24 and 48 hours after birth. Cerebral blood flow velocity (CBFV) was lower in the small-for-gestational age group, in the anterior cerebral artery (ACA). Doppler measurements were different statistically between the groups only for values related to peak systolic flow velocity (PSFV) and mean flow velocity (MFV) in the ACA. There was no significant difference for any evaluated parameters of flow velocity in the middle cerebral artery (MCA). It was concluded that SGA newborns showed PSFV and MFV significantly reduced only in the ACA. Weight/gestational age, neonatal polycythemia and mean arterial blood pressure values were statistically related to MFV in the ACA. In presence of fetal suffering, mean arterial blood pressure value...

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“…Hyperviscosity due to neonatal polycythemia causes cardiopulmonary failure, renal vein thrombosis, necrotizing enterocolitis, and central nervous system damage, and threatens the life of the infant (Francois, et al, 1984Black, et al, 1982. Fetal hypoxemia was suggested to be a cause of this neonatal polycythemia, but this has as yet to be established.…”

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confidence: 99%

Cord Transferrin and Ferritin Values for Erythropoiesis in Newborn Infants of Diabetic Mothers.

et al. 1989

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Neonatal polycythemia is a perinatal complication in infants of diabetic mothers. The cord CBC (complete blood counts), serum iron, transferrin and ferritin concentrations were studied in newborn infants of 9 GDM (gestational diabetes), 21 NIDDM (noninsulin-dependent diabetes mellitus), and 8 IDDM (insulin-dependent diabetes mellitus) mothers.The RBC (red blood cell) count, Hb (hemoglobin) and Het (hematocrit) of these infants were higher than control infants.There was no difference between the serum iron concentration of the infants of each group diabetic mothers and the infants in the control group, but the transferrin concentration was significantly higher and the ferritin was significantly lower in the infants of diabetic mothers than in those of control mothers. There was a significant negative correlation between transferrin and ferritin (r =-0.491 p <0.001). Erythropoiesis is considered to be enhanced in the fetuses of diabetic mothers, and the iron needed for erythropoiesis is reportedly transported from the mother to the fetus according to the demands of the fetus, but the iron storage was shown to be reduced in the fetuses of diabetic mothers.

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Neonatal Polycythemia and Hyperviscosity

Cited by 35 publications

References 58 publications

Viscosity Reduction of Red Blood Cells from Preterm and Full-Term Neonates and Adults in Narrow Tubes (Fahraeus-Lindqvist Effect)

Viscosity Reduction of Red Blood Cells from Preterm and Full-Term Neonates and Adults in Narrow Tubes (Fahraeus-Lindqvist Effect)

Velocimetria Doppler no período neonatal em recém-nascidos a termo pequenos para idade gestacional

Cord Transferrin and Ferritin Values for Erythropoiesis in Newborn Infants of Diabetic Mothers.

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