Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report

Jafarri, Sultan Aqeel; Alattas, Khalid M.; Bajawi, Sultan; Ahsan, Mohammad Kamrul; Al-Sheikh, Ali Mohammed; Buraik, Mohammed A.; Gamal, Amr Mohammed; Mustafa, Nadia S.

doi:10.1016/j.jdds.2016.10.001

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…In vitro studies have demonstrated that variations in the concentration of various coagulation factors affect thrombin generation, but translation into clinical practice is lacking. 26,27 Further studies stratifying cases by the degree of deficiency may help identify a possible link between extreme levels of coagulation factors and ischemic stroke.…”

Section: Inherited Thrombophiliasmentioning

confidence: 99%

Thrombophilia Testing After Ischemic Stroke

Omran

Hartman

Zakai

et al. 2021

Stroke

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Thrombophilia testing is frequently performed after an ischemic stroke, particularly when cryptogenic. However, there is minimal evidence supporting a significant association between most conditions assessed through thrombophilia testing and ischemic stroke, and the rationale for thrombophilia testing in many clinical situations remains uncertain. In this topical review, we review and contextualize the existing data on the risks, predictors, and outcomes of thrombophilic conditions in patients with ischemic stroke. We report that inherited thrombophilias have an uncertain relationship with ischemic stroke. Conversely, antiphospholipid syndrome, an acquired immune-mediated thrombophilia, seems to be a strong risk factor for arterial thromboembolic events, including ischemic stroke, and especially among young patients. Our findings suggest that certain circumstances may warrant targeted thrombophilia testing, such as stroke in the young, cryptogenic stroke, and high estrogen states. Future prospective studies should investigate the utility and cost effectiveness of thrombophilia testing in various stroke settings, including among patients with patent foramen ovale; as well as the optimal secondary stroke prevention regimen in patients with confirmed thrombophilia, particularly if no other potential stroke mechanism is identified.

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Section: Inherited Thrombophiliasmentioning

confidence: 99%

Thrombophilia Testing After Ischemic Stroke

Omran

Hartman

Zakai

et al. 2021

Stroke

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Dermatoses of the Neonate

Clayton,

Sharif

2024

Rook's Textbook of Dermatology

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This chapter provides an overview of neonatal skin function and intrauterine skin development. The impact on the skin of gestational age at birth is discussed along with cutaneous complications arising from prematurity and neonatal medical procedures. Skin care practices and considerations for neonates are summarised and physiological appearances and changes are described. On overview of disordered skin in neonates is provided, including pustular eruptions, atrophic skin lesions, disorders of neonatal fat, colloidion baby, blueberry muffin baby, purpura fulminans and common neonatal dermatosis. The clinical manifestions in a neonate of transplacental transfer of maternal autoantibodies is evaluated, including in conditions such as pemphigus vulgaris, pemphigus foliaceus, herpes gestationis, lupus erythematosus and maternal malignancy. Finally, on overview of infective skin pathologies and clinical manifestations in neonates is provided including viral, bacterial and fungal pathogens.

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Wounds resulting from non-malignant haematological disease: a case series

et al. 2023

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A proactive and systemic approach is imperative to preventing wounds due to disorders of non-malignant haematologic disease. Here, the authors provide several examples of patients with either a known history or acute diagnosis of a coagulation disorder with the aim of reviewing potential cutaneous injuries as well as diagnosis and treatment. A description of the wound and treatment course along with recommendations where appropriate are presented. The article serves as a general review for health professionals who may encounter patients with this disorder and who are involved in treatment decisions. After reviewing the article, the practitioner will be able to identify cutaneous injuries that may be secondary to an underlying haematological disorder, review the diagnosis and treatment recommended, and understand the need for a multidisciplinary approach to patient care.

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Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report

Cited by 4 publications

References 7 publications

Thrombophilia Testing After Ischemic Stroke

Thrombophilia Testing After Ischemic Stroke

Dermatoses of the Neonate

Wounds resulting from non-malignant haematological disease: a case series

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