Neonatal seizures, experience at Children Hospital and Institute of Child Health Multan

A, Rehman Malik; A, Iqbal Quddusi; Naila,

doi:10.12669/pjms.295.3847

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Primary metabolic abnormalities were found in 17.5% cases in the study by Abdur Rheman Malik [9]. Ashok Kumar and Veenu Gupta [10], carried out a study on 35 neonates to determine the frequency of biochemical abnormalities in neonatal seizures. Two thirds (66%) of neonates with seizures had biochemical abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hypomagnesemia in neonatal seizures in a tertiary care hospital in South India

Suganthi

Vikneshwari.

G³

2017

Int J Pediatr Res

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Introduction: Metabolic causes of neonatal seizures with good prognosis are hypoglycemia, hypocalcemia, hypomagnesemia. Some of hypocalcmic seizures are accompanied by hypomagnesemia, but magnesium levels are rarely investigated in resource restricted hospitals. Materials and Methods: A group of 150 neonates with seizures were studied. Analysis of serum Calcium, Magnesium and Sodium were done on the samples using conventional methods. Prevalence of hypomagnesemia, hypocalcemia and their association was estimated. Results: Metabolic abnormalities were present in 89 (59.3%) out of 150 cases. Of these, hypoglycemia and hypocalcemia were the most common with 39 (43.8%) and 28 (35.4%) cases respectively. The prevalence of hypomagnesemia was 5.3%. 87% of hypomagnesemia cases were associated with hypocalcemia implying the interrelation in pathophysiology. Among neonates with hypocalcemia, 20% had hypomagnesemia. Hence, there is a need to estimate magnesium levels in neonatal seizures because treatment is definitive with magnesium salts. Conclusion: Hypomagnesemia was a significant cause of neonatal seizures. Most of the neonates with hypomagnesemia had an associated hypocalcemia. It is necessary to estimate levels of magnesium in addition to calcium in all neonates with seizures.

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Section: Discussionmentioning

confidence: 99%

Prevalence of hypomagnesemia in neonatal seizures in a tertiary care hospital in South India

Suganthi

Vikneshwari.

G³

2017

Int J Pediatr Res

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“…Data were collected using a structured questionnaire for interviewing mothers in the NICU at admission. The questionnaires have been adapted and modified from different studies conducted in developed and non-developed countries (7,12,14,15). Additionally, a structured checklist adapted from the aforementioned studies was also used to abstract data on some maternal and neonatal determinants of neonatal seizure.…”

Section: Methods Of Data Collectionmentioning

confidence: 99%

Determinants of neonatal Seizure among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023: A multi-center unmatched case control study.

Alene,

Tsega,

terefe

et al. 2024

Preprint

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Background: Neonatal seizure is a common medical emergency that signals severe insult to the neonatal brain. It is a major risk factor for neonatal morbidity and mortality. It has a wide worldwide variation, ranging from 5 per 1,000 live births in the United States of America to 39.5 per 1,000 live births in Kenya. To decrease this significant figure, it is better to investigate its causes further. Therefore, this study aimed to assess its determinants since there was no prior evidence about it in the context of study area. Objective: Aim to assess the determinants of neonatal seizures among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023. Methods: An institution based unmatched case-control study was conducted on 531 admitted eligible neonates from January 1, 2023, to May 30, 2023. A pretested tool was employed to collect data. The collected data were coded, edited, and entered into Epi-data version 3.1 and then exported to SPSS 26. Chi-square and odds ratios were used to assess the relationship between factors associated with the occurrence of neonatal seizure. Model goodness of fit was tested by Hosmer and Lemeshow. Bivariate and multivariate analysis was declared at P<0.25 and P<0.05 respectively to show a significant association with neonatal seizure at a 95% level of significance. Results: A total of 506 (130 cases and 376 controls) of admitted neonates were used in the final analysis model. Neonates admitted within 24 hours of birth [AOR; 5.98 (95%, CI: 2.18-16.43)], gestational age <32 weeks [AOR; 2.89 (95%, CI: 1.29-6.53)], body temperature >37.5℃ [AOR; 4.82 (95%, CI: 1.82-12.76)], blood glucose level < 40g/dl [AOR; 4.95 (95%, CI: 2.06,11.88)], neonatal sepsis [AOR; 2.79 (95%, CI: 1.46-5.35)] and perinatal asphyxia [AOR; 8.25 (95%, CI: 4.23, 16.12)] were found to be determinants of neonatal seizure. Conclusion and recommendations: In this study, neonatal seizure was determined by the factors of neonatal age, gestational age<32 weeks, body temperature >37.5°C, blood glucose level < 40 g/dl, neonatal sepsis, and perinatal asphyxia. Therefore, the presence of such factors requires prompt recognition and treatment. Key words: Seizure, neonates, determinants, case control, Ethiopia.

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“…Birth asphyxia, perinatal infection, and hypoglycemia are the most frequently identifiable etiologies of NS in LMIC, based on studies from Pakistan, Kenya, Nigeria, and Iran. 15 , 16 , 23 , 24 Undiagnosed acute bilirubin encephalopathy may add to the problem in LMIC. The underrepresentation of intracranial hemorrhage in neonates living in LMIC could be explained by limited access to neuroimaging, especially brain magnetic resonance imaging (MRI).…”

Section: Etiologymentioning

confidence: 99%

Neonatal Seizures in Low- and Middle-Income Countries: A Review of the Literature and Recommendations for the Management

Spenard,

Salazar Cerda,

Nevzat Çizmeci

2024

Turkish Archives of Pediatrics

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Neonatal seizures are a common cause of neonatal intensive care unit (NICU) admission and a significant source of morbidity and mortality worldwide. Over the recent decades, there have been significant improvements in perinatal and neonatal medicine and electroencephalographic monitoring that have enhanced the diagnosis and treatment of neonatal seizures in high-income countries. However, the management of neonatal seizures remains a major challenge in low- to middle-income countries, where the availabilityof resources is limited. The purpose of this article is to present a comprehensive review of the current evidence on the etiology, pathophysiology, diagnosis, and treatment of neonatal seizures and to offer practical management recommendations that could be implemented in resource-limited settings.

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Neonatal seizures, experience at Children Hospital and Institute of Child Health Multan

Cited by 5 publications

References 18 publications

Prevalence of hypomagnesemia in neonatal seizures in a tertiary care hospital in South India

Prevalence of hypomagnesemia in neonatal seizures in a tertiary care hospital in South India

Determinants of neonatal Seizure among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023: A multi-center unmatched case control study.

Neonatal Seizures in Low- and Middle-Income Countries: A Review of the Literature and Recommendations for the Management

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