Neonatal Seizures: Incidence, Etiologies, Clinical Features and EEG Findings in the Neonatal Intensive Care Unit

Hu, Su Ching; Hung, Kun Long; Chen, Hui Ju

doi:10.4172/2472-0895.1000117

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…It is much lower than that reported by Sharek et al (4) that were 5.1% and that reported by Glass, (30) , as seizures rate ranged between 1 to 5 per 1000 live births. A study done in 2017 by Hu et al (31) revealed that seizures were 18.32%. Pisani et al (32) reported neonatal seizures were 2.29 per 1000 live births.…”

Section: Discussionmentioning

confidence: 98%

Measuring Adverse Events in the Neonatal Intensive Care Units in Mit-Ghamr Central Hospital

2023

The Egyptian Journal of Hospital Medicine

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Background: Children in neonatal intensive care units (ICU) are more susceptible to medical errors. Measuring adverse events is a very important issue for patient safety and using trigger tool methodology as a different strategy is beneficial to both more focused as well as rapid chart review to establish whether or not an adverse event occurred. Aim: For evaluation the prevalence of adverse events (AEs) in Mit-Ghamr Neonatal ICU using the trigger tool and to evaluate the prevalence of adverse events in Mit-Ghamr neonatal Intensive Care Unit with other hospitals in Egypt and abroad. Subjects and Methods: A cross sectional analytic study using medical record review and charts study was done including 511 medical records, it consisted of all neonates admitted to Mit-Ghamr neonatal ICU between 1 st January to 31 December 2017. Results: a total of 465 adverse events with incidence rate of 0.91 adverse event/patient and 1.16 trigger/patient. The most common adverse event was nosocomial infections with more than half of the overall adverse events (n=282; 55.2%), followed by catheter infiltration (n=64; 12.5%), hypotension was 5.5%, respiratory arrest 4.7%, accidental extubation 4.1%, death 3.5%, renal insufficiency 2%, and seizures was 0.6%. Category (F) was the most prevalent harm category among the occurred adverse events (45.7%) followed by category (E) (28.8%). Only a minority (3.1%) had a permanent harm (category G) and category H was 22.4%. Conclusion: Nosocomial infections constitute the majority of all adverse events, followed by catheter infiltration and hypotension.

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Section: Discussionmentioning

confidence: 98%

Measuring Adverse Events in the Neonatal Intensive Care Units in Mit-Ghamr Central Hospital

2023

The Egyptian Journal of Hospital Medicine

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“…[1][2][3][4][5] Main causes for NS include hypoxic ischemic encephalopathy, intracranial hemorrhage, stroke, intracranial infection, and metabolic disorders. [6][7][8][9][10] Since NS carry a major risk for death (up to 20%) or subsequent neurological disability, 11 it is crucial to identify risk factors associated with a higher risk for NS. The identification of such risk factors, whether modifiable or not, can allow the medical staff and public health scholars and policymakers to better predict populations at risk and to work toward tackling modifiable risk factors.…”

Section: Introductionmentioning

confidence: 99%

Communal Poverty Is a Significant Risk Factor for Neonatal Seizures

Tanous,

Haj-Yahya,

Ershead

et al. 2023

Neuropediatrics

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Introduction Neonatal seizures (NS) are a severe condition with significant mortality and long-term morbidity. This study aims to identify risk factors for NS in a racially or ethnically diverse population in Israel. Methods This is a case–control study. The cases were all newborns born between 2001 and 2019 at Emek Medical Center in Israel and admitted with NS. Two healthy controls born in the same period were matched for each case. Demographic, maternal, and neonatal variables were abstracted from the electronic medical files. Results A total of 139 cases were matched with 278 controls. Residing in a town with lower socioeconomic status (SES), primiparity and abnormal prenatal ultrasound were significantly associated with NS. Prematurity, assisted delivery, a lower birthweight, being small for gestational age, and lower Apgar score were also associated with NS. In two different multivariable regression models, lower SES (odds ratio [OR] = 4.07) and Arab race/ethnicity (OR = 2.66) were risk factors for NS. Other significant risk factors in the multivariable regression models included an assisted mode of delivery (OR = 2.33), prematurity (OR = 2.27), and a 5-minute Apgar score below 7 (OR = 54.1). Discussion Communal poverty, as reflected by lower SES of towns of residence, was found to be a stronger risk factor than race or ethnicity, for NS. More studies should focus on social class, as a risk factor for maternal and neonatal adverse outcomes. As SES is a modifiable variable every effort should be invested in fighting communal poverty and improving the SES of impoverished towns and population.

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Risk Factors for Mortality among Newborns with Neonatal Seizures

et al. 2020

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Objective The aim of the study is to examine the incidence and risk factors for death among neonates who developed neonatal seizures (NS) in an ethnically distinctive community with high consanguinity rate in Israel. Methods Retrospective study was conducted at a single institution on data between January 2001 and January 2016. All neonates diagnosed with NS developed up to age 28 days were included. Mortality was defined as death within the first year of life. Results Of all 69,460 neonates born during the study period, 118 (1.7 per 1,000 live births) developed NS; 35 (29.7%) died within the first year while 83 (70.3%) survived. The leading causes of death were developmental brain malformation (31.4%), genetic/metabolic (20%), hypoxic ischemic encephalopathy (20%), intracranial hemorrhage (11.4%) and infections (11.4%). Any consanguinity between the parents was found in 18 and 14.6% among the survivors and deceased groups, respectively (p = 0.24). Developmental brain malformations that lead to death were present in 3.6 and 31.4% in the survivors and deceased groups, respectively (p = 0.001; relative risk 8.70; 95% confidence interval 2.58–29.27). Stepwise backward logistic regression analysis revealed that developmental brain malformations (p < 0.0001), use of more than one antiepileptic medication (p = 0.006), and multiorgan failure (p = 0.004) were significant risk factors that predicted death. Conclusion The results of the current study show that developmental brain malformations that cause NS were the leading risk factor for death.

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Neonatal Seizures: Incidence, Etiologies, Clinical Features and EEG Findings in the Neonatal Intensive Care Unit

Cited by 4 publications

References 7 publications

Measuring Adverse Events in the Neonatal Intensive Care Units in Mit-Ghamr Central Hospital

Measuring Adverse Events in the Neonatal Intensive Care Units in Mit-Ghamr Central Hospital

Communal Poverty Is a Significant Risk Factor for Neonatal Seizures

Risk Factors for Mortality among Newborns with Neonatal Seizures

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