Neonatal Sepsis

Alojipan, Leticia C.; Andrews, Billy F.

doi:10.1177/000992287501400209

Cited by 20 publications

(4 citation statements)

References 8 publications

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“…Since the susceptibility of males to sepsis is higher, due to the possession of a single x chromosome thought to contain a gene which regulates the synthesis of immunoglobulins (Rhodes ef al. 1969, Alojipan and Andrews 1981), the higher mortality rate among females is sur-…”

Section: Discussionmentioning

confidence: 99%

Neonatal Bacterial Meningitis in the Middle Belt of Nigeria

Airede

1993

Develop Med Child Neuro

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SUMMARY A three‐year prospective study of neonatal meningitis in a tertiary hospital in Nigeria was carried out to determine its clinical spectrum and particular characteristics. The 36 infants studied represented a high incidence of 1.9 per 1000 live births, and the infection was significantly higher among lowbirthweight babies. Non‐specific signs and symptoms were common, and temperature instability was a constant finding. Specific neurological manifestations were noted that differed from other reports in the literature and contributed significantly to outcome. The most common aetiological pathogen isolated was Gram‐positive Staphylococcus aureus and the most common Gram‐negative organisms were Klebsiella spp: there was no case of group B streptococci. The pathogens isolated were also at variance with other reports. The mortality rate was 33 per cent and was higher for females. There was no significant difference in outcome between inborn and referred infants, nor between early onset and late onset of the disease. A bulging anterior fontanelle was a significant indicator of poor prognosis. Gentamicin and ceftazidime were the most appropriate antibiotics. RÉSUMÉ Méningítes bactériennes néo‐natales dans la ‘middle‐bell’ du Nigéria Une étude prospective durant trois ans et concernant les méningites néonatales constatees dans un hǒpital tertiaire du Nigéria a été entreprise pour déterminer I'allure clinique et les principales caractéristiques. Les 36 nourrissons examinés traduisaient une incidence élevée de 1.9 cas pour 1OOO naissances vivantes et l'infection est apparue significativement plus elevee parmi les nourrissons de faible poids de naissance. Les signes non spécifiques et les symptǒmes étaient communs et I'instabilite thermique ctait une caracteristique constante. Des manifestations neurologiques spécifiques ont été notees qui differaient de celles d'autres publications et qui contribuaient significativement au devenir. L'etiologie pathogène la plus comrnunement isolee fut le staphylocoque dore parmi les germes gram + et la Klebsiella spp parmi les gram ‐; aucun cas n'etait liéà un streptocoque du groupe B. Les germes isolés étaient égalernent différents de ceux d'autres publications. Le taus de mortalité fut de 33 pour cent, plus éléve chez les filles. II n'a pas été observé de différénce de devenir zntre les nourrissons nes a I'hCApital ou adressés ulterieurement. ni selon un debut precoce ou tardif de I'affection. Une fontanelle antérieure bornbee Sut un indicateur significatif de mauvais pronostic. La gentamicine et la ceftazidime se montrèrent les antibiotiques les plus appropries. ZUSAMMENFASSUNG Neonarale baicterielle Meningitis in Mittelnigeria Es wurde eine prospektive 3‐Jahresstudie über neonatale Meningitis in einem Krankenhaus der dritten Versorgungsstüfe in Nigeria durchgefuhrt, um das klinische Spektrum und die besonderen Charakteristika zu untersuchen. 36 Säuglinge wurden untersucht, das bedeutete eine hohe lnzidenz Von 1.9 pro 1000 Lebendgeburten; die Infek...

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Section: Discussionmentioning

confidence: 99%

Neonatal Bacterial Meningitis in the Middle Belt of Nigeria

Airede

1993

Develop Med Child Neuro

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“…Unfortunately no atoxic antibiotic is of any value against septicaemia caused by Gramnegative rods, which still are very important in newborn infants (2,29). Therefore we have used Kanamycin although at present Gentamycin may be the drug of choice (7, 22, 23).…”

Section: Actu Pzdiirtr Sclrnd65mentioning

confidence: 99%

Septicaemia of the Newborn, Associated With Ruptured Foetal Membranes. Discoloured Amniotic Fluid or Maternal Fever

Knudsen

STEINRUD

1976

Acta Paediatrica

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Abstract. The incidence of neonatal septicaemia associated with prolonged rupture of foetal membranes, discoloured amniotic fluid and/or maternal fever was investigated. A total of 807 blood cultures were performed on 329 neonates, the placental end of 239 umbilical cords and on 239 mothers. The study showed that in 97% of the neonates with a complicated delivery there was no evidence of septicaemia. Septicaemia was verified in 3% of the infants, and was intimately associated with low birth weight (p=0.02), neonatal asphyxia (p<10‐4), clinical evidence of septicaemia (p<10‐4) and maternal fever (p=0.002). The incidence was particularly high in premature infants with neonatal asphyxia (27%) and in neonates born to febrile mothers (20%). None of the mothers showed any evidence of septicaemia, and haematogenous, transplacental spread of infection to the child was not seen. Routine prophylactic antibiotic therapy in neonates with a complicated delivery should therefore be reserved, in our opinion, for those infants at high risk of infection.

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“…Neonatal septicemia is still a serious condition with attendant high mortality (1,4,5). In numerous retrospective studies certain predisposing factors related to pregnancy, delivery as well as neonatal diseases have been identified (4,14).…”

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confidence: 99%

Neonatal Septicemia and Perinatal Risk Factors

1979

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Many methods for screening and prediction of neonatal septicemia have been tried. In this study a score, related to both perinatal risk factors and neonatal diseases, was tested upon healthy newborn infants, infants with septicemia and infants with other diseases. Statistical differences were found between infants with neonatal septicemia and infants with other neonatal diseases as well as normal newborns. It was also possible to find a relationship between certain predisposing factors and predominance of certain pathogens. Complications during pregnancy and delivery were most often found in the group B streptococcal, combinations of invasive procedures and neonatal diseases in the staphylococcal group and surgical procedures in the gram-negative group.

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Neonatal Sepsis

Cited by 20 publications

References 8 publications

Neonatal Bacterial Meningitis in the Middle Belt of Nigeria

Neonatal Bacterial Meningitis in the Middle Belt of Nigeria

Septicaemia of the Newborn, Associated With Ruptured Foetal Membranes. Discoloured Amniotic Fluid or Maternal Fever

Neonatal Septicemia and Perinatal Risk Factors

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