2022
DOI: 10.1038/s41390-021-01883-y
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Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials

Abstract: Background The lack of a consensus definition of neonatal sepsis and a core outcome set (COS) proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents. Methods A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In the included studies, the described outcomes were extracted in acc… Show more

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Cited by 12 publications
(7 citation statements)
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“…Definitions of neonatal sepsis in premature infants vary among published studies 53 , 54 . We chose to model events of culture-proven sepsis, knowing that this definition, while unequivocal, also excludes clinically important events associated with a negative blood culture.…”
Section: Discussionmentioning
confidence: 99%
“…Definitions of neonatal sepsis in premature infants vary among published studies 53 , 54 . We chose to model events of culture-proven sepsis, knowing that this definition, while unequivocal, also excludes clinically important events associated with a negative blood culture.…”
Section: Discussionmentioning
confidence: 99%
“…Definitions of neonatal sepsis in premature infants vary widely among published studies 45,46 due to challenges in developing a consensus definition for sepsis in this unique population 47 . We chose to model events of culture-proven sepsis, knowing that this definition, while unequivocal, also excludes many clinically important events associated with a negative blood culture.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, Henry et al published a systematic review of core outcomes from randomised trials of therapeutic interventions in neonatal sepsis. They reported 88 unique outcomes from 90 included studies [ 9 ].…”
Section: Methodsmentioning
confidence: 99%
“…The lack of a universally accepted definition for neonatal sepsis inhibits efforts to improve accurate diagnostic and prognostic testing methods for this vulnerable population [ 8 ]. In addition, there is substantial heterogeneity in the outcomes measured and reported in studies evaluating the effectiveness of treatments for neonatal sepsis, with Henry et al identifying 88 outcomes across 90 studies [ 9 ]. This heterogeneity in outcomes limits the ability to compare, contrast, and synthesise [ 10 ] the findings of individual studies and contributes to research waste.…”
Section: Introductionmentioning
confidence: 99%