Neonatal sepsis: an international perspective

Vergnano, Stefania; Sharland, Mike; Kazembe, Peter N.; Mwansambo, Charles; Heath, Paul T

doi:10.1136/adc.2002.022863

Cited by 401 publications

(412 citation statements)

References 36 publications

(31 reference statements)

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“…Neonatal sepsis incidents in Asia occur within the rate of 7.1-38/1000 live births. The most common bacteria causing neonatal sepsis in Asian and African countries are Gram-negative bacteria [2][3][4]13]. The result of this study also revealed that BSIs in NICU was dominated by Gramnegative bacteria (72% or 162 isolates out of 225 isolates).…”

Section: Discussionsupporting

confidence: 57%

“…In this study, 225 neonatal patients admitted in NICU had BSIs. In developed countries, most nosocomial infections in neonatal patients are caused by BSIs and pneumonia [12], while in developing countries, most of the baby deliveries are performed at home, so various infections might occur, such as septicaemia, meningitis, respiratory infections, diarrhea and neonatal tetanus, although, BSIs poses a greater threat [13]. Neonatal sepsis incidents in Asia occur within the rate of 7.1-38/1000 live births.…”

Section: Discussionmentioning

confidence: 99%

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The Study of Multidrug-Resistance in Neonatal Intensive Care Unit at the Central Java Hospital

Sari

Nuryastuti²,

Wahyono

2017

Asian J Pharm Clin Res

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Objective: Multidrug-resistance (MDR) is defined as an acquired non-susceptibility to at least one agent in three or more antimicrobial categories. MDR can be caused by several factors, including the misuse of antibiotics. Resistance to antibiotics still poses a global challenge, especially in Indonesia. This study aimed to identify patterns of MDR in neonatal intensive care unit (NICU) at the Central Java Hospital, during the period of January 2014 to December 2015. Methods:The study was conducted using a descriptive retrospective design. The research population comprised 225 patients. The patient inclusion criteria were neonatal patients treated in NICU ward with infection diagnosis. All patients had culture and sensitivity examinations on their bloods. The culture and sensitivity examinations were performed by microbiology clinicians. Results:The most common infection type was sepsis (60%). The most common bacteria found in the blood specimen of patients in the NICU ward was Gram-negative bacteria with a 72% rate; the other was Gram-positive bacteria. Bacteria which infected patients include Klebsiella pneumoniae ssp. pneumoniae, Pseudomonas aeruginosa, Burkholderia cepacia, Acinetobacter baumannii, Enterobacter cloacae ssp. cloacae, Serratia marcescens, Staphylococcus haemolyticus, and Staphylococcus epidermidis. The research result showed that 97.8% MDR cases were reported in the NICU ward. Antibiotics which were still potent for all bacteria found in NICU patients were tigecycline, meropenem and ciprofloxacin (for Gram-negative bacteria) and tigecycline, linezolid, nitrofurantoin, moxifloksacin, and vancomycin (for Gram-positive bacteria). Conclusion:A high percentage of MDR occurred in NICU patients. Sepsis is the most common diagnosis in NICU patients. The usage of third generation antibiotics should be limited and regulated systematically.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

The Study of Multidrug-Resistance in Neonatal Intensive Care Unit at the Central Java Hospital

Sari

Nuryastuti²,

Wahyono

2017

Asian J Pharm Clin Res

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“…Además, en el HNAL los casos de sepsis confirmada han aumentado en los últimos años, en el 2005 se reportó una incidencia de 1,74 por cada 1000 nacidos vivos (datos no publicados). En América del Sur y el Caribe la incidencia es de 3,59 a 8,91 por cada 1000 nacidos vivos (18) . En Chile, algunos centros han reportado un caso por cada 1000 nacidos vivos (19) , similar a los países desarrollados.…”

Section: Discussionunclassified

Características microbiológicas y terapéuticas de la sepsis neonatal confirmada en un hospital de Lima, Perú

Alvarado-Gamarra

Alcalá-Marcos

Abarca-Alfaro

et al. 2016

Rev Peru Med Exp Salud Publica

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“…Drug sensitivity patterns shows that 5-50%staphylococcus including coagulase negative & streptococcus have developed resistance against third generation cephalosporin. 13,14 In our study gram negative organism was observed in 6.67% (12/180), which include 2(1.1%) acinetobacter, 2(1.1%) E.coli, 5(2.8%) klebsiella and 3 (1.6%) pseudomonas. Only 1 were gram positive that is enterococcus.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Sepsis; Common Bacterial Isolates and Their Antimicrobial Susceptibility Patterns in Neonatal Intensive Care Unit, Islamabad

Abbasi¹,

Jabeen

Khatoon³

2017

TPMJ

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Neonatal sepsis: an international perspective

Cited by 401 publications

References 36 publications

The Study of Multidrug-Resistance in Neonatal Intensive Care Unit at the Central Java Hospital

The Study of Multidrug-Resistance in Neonatal Intensive Care Unit at the Central Java Hospital

Características microbiológicas y terapéuticas de la sepsis neonatal confirmada en un hospital de Lima, Perú

Neonatal Sepsis; Common Bacterial Isolates and Their Antimicrobial Susceptibility Patterns in Neonatal Intensive Care Unit, Islamabad

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