Neonatal tryptophan dietary restriction alters development of retinotectal projections in rats

González, Éricka M.C.; Penedo, Letícia Abel; Oliveira-Silva, Priscilla; Campello-Costa, Paula; Guedes, Rubem Carlos Araújo; Serfaty, Claudio Alberto

doi:10.1016/j.expneurol.2008.02.009

Cited by 25 publications

(22 citation statements)

References 79 publications

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“…Since agonistic displays may be markedly affected by this interaction, xenoestrogenic activity of BPA as it relates to ER and ERRγ agonism (general: Zuercher et al 2005; Ben-Jonathan and Steinmetz 1998; human: Okada et al 2008; rat: Washington et al 2001), and the consequent effects on the serotonergic system during development may be an example of BPA-induced neuroendocrine disruption. Because serotonin is important during brain development and in controlling levels of aggression, and BPA enhances 5-HT activity, BPA-induced changes in embryonic 5-HT levels may be responsible for altered brain development (fish: Elipot et al 2013; Dahlbom et al 2012; Clotfelter et al 2007; mice: Rood and Beck 2013; rat: Cao et al 2013; Donner and Handa 2011; Matsuda et al 2010; González et al 2008; Honma et al 2006; Orozco-Suárez 2003; Persico et al 2000; Yan et al 1997). …”

Section: Discussionmentioning

confidence: 99%

Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions

Weber

Hoffmann

Hoke³

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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Developmental bisphenol A (BPA) exposure is associated with adverse behavioral effects, although underlying modes of action remain unclear. Because BPA is a suspected xenoestrogen, the objective was to identify sex-based changes in adult zebrafish social behavior developmentally exposed to BPA (0.0, 0.1 or 1 μM) or one of two control compounds (0.1μM 17β-estradiol [E2], and 0.1 μM GSK4716, a synthetic estrogen-related receptor γ ligand). A test chamber was divided lengthwise so each arena held one fish unable to detect the presence of the other fish. A mirror was inserted at one end of each arena; baseline activity levels were determined without mirror. Arenas were divided into 3, computer-generated zones to represent different distances from mirror image. Circadian rhythm patterns were evaluated at 1–3 (= AM) and 5–8 (= PM) hr postprandial. Adult zebrafish were placed into arenas and monitored by digital camera for 5 min. Total distance traveled, % time spent at mirror image, and number of attacks on mirror image were quantified. E2, GSK4716, and all BPA treatments dampened male activity and altered male circadian activity patterns; there was no marked effect on female activity. BPA induced non-monotonic effects (response curve changes direction within range of concentrations examined) on male % time at mirror only in AM. All treatments produced increased % time at the mirror during PM. Male attacks on the mirror were reduced by BPA exposure only during AM. There were sex-specific effects of developmental BPA on social interactions and time-of-day of observation affected results.

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Section: Discussionmentioning

confidence: 99%

Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions

Weber

Hoffmann

Hoke³

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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“…Recent evidence from a tryptophan restriction model shows that decreased 5-HT content in animals fed with a corn-/gelatin-based diet is associated with a developmental delay in the time course of axonal elimination in retinotectal projections, consistent, therefore, with a decreased developmental plasticity in the visual system [38] . Also, it has recently been shown that tryptophan restriction is associated with high basal levels of cAMP, which could be acting as a stabilization signal that could delay axonal elimination ( fig.…”

Section: Role For 5-ht In Developmental Plasticitymentioning

confidence: 98%

“…Low tryptophan diet is an efficient way to induce nonpharmacological 5-HT deprivation [37,38] . Recent evidence from a tryptophan restriction model shows that decreased 5-HT content in animals fed with a corn-/gelatin-based diet is associated with a developmental delay in the time course of axonal elimination in retinotectal projections, consistent, therefore, with a decreased developmental plasticity in the visual system [38] .…”

Section: Role For 5-ht In Developmental Plasticitymentioning

confidence: 99%

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Nutritional Tryptophan Restriction and the Role of Serotonin in Development and Plasticity of Central Visual Connections

Serfaty

Oliveira-Silva

Faria-Melibeu

et al. 2008

Neuroimmunomodulation

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Tryptophan is an essential amino acid and metabolic precursor of serotonin. Serotonin is both a classical neurotransmitter and a signaling molecule that plays crucial roles in the development of neural circuits and plasticity. The specification of neural circuits in rodents occurs during the postnatal period with conspicuous influence of environmental factors including the nutritional status. Sensory, motor and cognitive systems develop during a critical period, a time window that is crucial to the use-dependent organization of neuronal circuits. This review presents recent experimental findings that disclose some mechanism of tryptophan- and serotonin-dependent plasticity in the developing and adult brain.

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“…Rat pups and lactating dams fed a tryptophan-restricted diet showed growth retardation accompanied by serotonin depletion and reduced developmental plasticity in the brain (129,130). Young rats fed a tryptophan-restricted diet that was 80% lower in tryptophan than a control diet showed decreased serotonin content in brain and altered brain morphology (131,132).…”

Section: Limitation Of Essential Amino Acids and Growth In Animal Modelsmentioning

confidence: 99%

Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting

Semba

Trehan

González-Freire

et al. 2016

Advances in Nutrition

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Stunting is the best summary measure of chronic malnutrition in children. Approximately one-quarter of children under age 5 worldwide are stunted. Lipid-based or micronutrient supplementation has little to no impact in reducing stunting, which suggests that other critical dietary nutrients are missing. A dietary pattern of poor-quality protein is associated with stunting. Stunted children have significantly lower circulating essential amino acids than do nonstunted children. Inadequate dietary intakes of essential amino acids could adversely affect growth, because amino acids are required for synthesis of proteins. The master growth regulation pathway, the mechanistic target of rapamycin complex 1 (mTORC1) pathway, is exquisitely sensitive to amino acid availability. mTORC1 integrates cues such as nutrients, growth factors, oxygen, and energy to regulate growth of bone, skeletal muscle, nervous system, gastrointestinal tract, hematopoietic cells, immune effector cells, organ size, and whole-body energy balance. mTORC1 represses protein and lipid synthesis and cell and organismal growth when amino acids are deficient. Over the past 4 decades, the main paradigm for child nutrition in developing countries has been micronutrient malnutrition, with relatively less attention paid to protein. In this Perspective, we present the view that essential amino acids and the mTORC1 pathway play a key role in child growth. The current assumption that total dietary protein intake is adequate for growth among most children in developing countries needs reevaluation. Adv Nutr 2016;7:853-65.

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Neonatal tryptophan dietary restriction alters development of retinotectal projections in rats

Cited by 25 publications

References 79 publications

Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions

Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions

Nutritional Tryptophan Restriction and the Role of Serotonin in Development and Plasticity of Central Visual Connections

Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting

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