Neonatal tumours: A thirty‐year population‐based study

Abstract

Estimates of the incidence and outcome of tumours in neonates are uncertain and most reports relate to selected experience in single centres. The definition of neonatal tumour is also unclear and histology is not always an accurate predictor of outcome. This report documents the incidence, clinical features, and outcome of neonatal tumours (birth-3 months) in a population-based paediatric register over a 30-year period from 1960-89. Case note and pathology review identified 170 cases for analysis, of which 21 were leukaemias, 14 CNS tumours, and 135 solid tumours of differing types. Fifty-eight percent were diagnosed in the first month and mature teratoma was the most common diagnosis (29%). Overall incidence increased over the period of the study. Important family medical history was identified in 16% of cases and 15% of patients had associated congenital abnormalities. Overall survival at 1 year was 55%, with leukaemia having the poorest prognosis. Treatment strategies must be individualised but many patients may have a better prognosis than expected and would benefit from assessment at a designated paediatric oncology centre.

Spectrum and outcome of prenatally diagnosed fetal tumors

“…The most common tumors reported from pediatric oncology units or tumor registries are neuroblastoma, teratoma and retinoblastoma 19,21,22,24,25 . Among cardiac tumors diagnosed in neonates, about 75% consist of rhabdomyomas, with an associated tuberous sclerosis in up to 70% of cases 26 .…”

“…SD (1) TOP (1) Cardiomegaly (1) Maternal digoxin (1) CS (6) Alive and well (4) Pericardial effusion (1) Major handicap (3) Hemangioma (2) 27 (24)(25)(26)(27)(28)(29)(30) Cardiomegaly and fetal anemia (1) 38 CS (2) Alive and well (2) Turner mosaic (1) Ranula (2) 26 (23)(24)(25)(26)(27)(28) 38 SD (1) Alive and well (2) CS (1) Struma (3) 27 (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) Polyhydramnios (2) Amniodrainage (2) 37 (29-42) SD (2) Alive and well (2) Hydrops fetalis (1) Intra-amniotic L-thyroxine (2) CS (1) NND (1) Intravenous L-thyroxine (1) Teratoma (4) 23 …”

“…Maternal digoxin (1) CS (1) NND (2) Cardiomegaly (2) Porencephaly (1) Thorax (8) Lymphangioma (8) 25 (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36) Hydrops fetalis (1) 39 (38-40)…”

“…Alive and well (4) CS (1) Mesenteric cyst (3) 20 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) Polyhydramnios (1) 40 (40-41)…”

“…Major handicap (2) Sacrococcygeal Teratoma (9) 22 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) Polyhydramnios (3) Amniodrainage (3) 34 (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) CS (6) TOP (1) region (9) Hydrops fetalis (2) RFA (1) IUFD (2) Heart failure (2) The gestational age and mode of delivery varied with the site of origin and histology of the tumor. The majority of infants was delivered near term, although cases with teratoma were frequently associated with preterm birth (77.8%).…”