Neopicrorhiza scrophulariiflora (Pennell) Hong: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety

Rokaya, Maan Bahadur; Parajuli, Bidur; Bhatta, Kuber Prasad; Timsina, Binu

doi:10.1016/j.jep.2019.112250

Cited by 11 publications

(3 citation statements)

References 49 publications

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“…This local knowledge is valuable not only for sustaining traditional medical practices but also for addressing future healthcare needs and conservation, with potential applications in modern pharmacology. In countries like Nepal, where contemporary pharmaceuticals are expensive and limited in remote mountain areas, the centuries-old practice of traditional medicine remains a practical and essential alternative (Chaudhary et al 2023, Kunwar et al 2015, Rokaya et al 2020.…”

Section: Discussionmentioning

confidence: 99%

Traditional socio-cultural utilization and harvesting practices of an alpine medicinal herb, Neopicrorhiza scrophulariiflora in Khumbu Valley, Nepal

Ghimire,

Gurung,

K.C.

et al. 2023

Ethnobot. Res. App.

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Background: This study aimed to document the traditional knowledge of people in the Khumbu Valley within Sagarmatha National Park and Buffer Zone in Nepal regarding the utilization and harvesting practices of the Himalayan medicinal plant Neopicrorhiza scrophulariiflora, which is under threat due to over-harvesting. Methods:The study used focus group discussions and key informant interviews to gather ethnobotanical knowledge from residents of seven enclave settlements of the park buffer zone. These settlements were later grouped into three village clusters based on their elevation. A total of 145 individuals of four ethnic groups with age between 20 and 72 years were interviewed. We analyzed the variation in the knowledge and usage of the plant among respondents in different village clusters, by gender, age-class, and ethnicity. Results:The majority of respondents were familiar with the plant and its medicinal value, mainly in the treatment of upper respiratory tract illnesses, gastrointestinal disorders, diabetes, and hypertension. There was no significant association between village clusters and the awareness of the plant's use for specific diseases. However, there was a significant relationship between the village cluster and the number of use reports for different diseases. This suggests variations in the applications of the plant for treating specific ailments across different geographic locations. Females showed higher awareness of the plant's medicinal uses, but gender did not significantly affect use reports for specific diseases or the overall number of use reports. Adults and seniors had the highest awareness of the plant's medicinal uses, with use reports increasing with age class. Ethnicity did not significantly influence awareness or use reports. Rhizomes of N. scrophulariiflora are primarily collected for local use, sometimes exchanged among villagers or used as gifts. Preferred harvesting seasons varied by age, with older individuals favoring mature stages. Younger harvesters showed less concern for sustainable harvesting practices.Conclusions: N. scrophulariiflora is recognized for its potential in treating various health issues. The study reveals variations in the knowledge and utilization of N. scrophulariiflora based on geographic location, gender, and age-class, but not ethnicity. The study highlights a generational gap in the knowledge of plant usage, with younger generations losing traditional knowledge due to economic transformation, particularly as they transition to tourism-related livelihoods. To preserve this vital resource and its associated traditional knowledge, efforts should be made to educate and engage younger generations and promote sustainable harvesting practices in the region.

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Section: Discussionmentioning

confidence: 99%

Traditional socio-cultural utilization and harvesting practices of an alpine medicinal herb, Neopicrorhiza scrophulariiflora in Khumbu Valley, Nepal

Ghimire,

Gurung,

K.C.

et al. 2023

Ethnobot. Res. App.

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“…kurrooa Royle ex Benth. (Huhuanglian) originated from India of Rhizoma Picrorhizae in the Chinese Pharmacopoeia 1995 edition [ 59 ]. However, in resource exploitation, some plant medicines whose related species were found in China had no pharmacological effects similar to target medicines [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

The biology of medicinal resource substitution in Salvia

et al. 2021

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Background The decrease of wild reserves and the sharp increase of market demand have led to resource substitution, but it is still not clear how to discover medicinal alternative resources. Here we reveal the biology of medicinal resource substitution in the case of Salvia. Methods A hypothesis was put forward that phylogeny and ecology were the main factors which determined alternative species selection. Phylogenetic analysis was performed based on chloroplast genomes. Spatial climatic pattern was assessed through three mathematical models. Results Salvia miltiorrhiza and alternative species were mainly located in Clade 3 in topology, and their growth environment was clustered into an independent group 3 inferred from principal component analysis. Correlation and Maxent major climate factor analyses showed that the ecological variations within each lineage were significantly smaller than the overall divergent between any two lineages. Mantel test reconfirmed the inalienability between phylogeny and ecology (P = 0.002). Only the species that are genetically and ecologically related to S. miltiorrhiza can form a cluster with it. Conclusions Phylogenetic relationship and geographical climate work together to determine which species has the potential to be selected as substitutes. Other medicinal plants can learn from this biology towards developing alternative resources.

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“…For example, Picroihiza scrophularii ora (Xizang Huanglian) was discovered to be a substitute for P. kurrooa Royle ex Benth. (Huhuanglian) originated from India of Rhizoma Picrorhizae in the Chinese Pharmacopoeia 1995 edition [59]. However, in resource exploitation, some plant medicines whose related species were found in China had no pharmacological effects similar to target medicines [31].…”

Section: Discussionmentioning

confidence: 99%

The Biology of Medicinal Resource Substitution in Salvia

Cui¹,

Chen²,

Bao-sheng³

et al. 2021

Preprint

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Background: The decrease of wild reserves and the sharp increase of market demand have led to resource substitution, but it is still not clear how to discover medicinal alternative resources. Here we reveal the biology of medicinal resource substitution in the case of Salvia.Methods: A hypothesis was put forward that phylogeny and ecology were the main factors which determined alternative species selection. Phylogenetic analysis was performed based on chloroplast genomes. Spatial climatic pattern was assessed through three mathematical models. Results: S. miltiorrhiza and alternative species were mainly located in Clade 3 in topology, and their growth environment was clustered into an independent group 3 inferred from Principal Component analysis. Correlation and Maxent major climate factor analyses showed that the ecological variations within each lineage were significantly smaller than the overall divergent between any two lineages. Mantel test reconfirmed the inalienability between phylogeny and ecology (P = 0.002). Only the species that are genetically and ecologically related to S. miltiorrhiza can form a cluster with it. Conclusion: Phylogenetic relationship and geographical climate work together to determine which species has the potential to be selected as substitutes. Other medicinal plants can learn from this biology towards developing alternative resources.

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Neopicrorhiza scrophulariiflora (Pennell) Hong: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety

Cited by 11 publications

References 49 publications

Traditional socio-cultural utilization and harvesting practices of an alpine medicinal herb, Neopicrorhiza scrophulariiflora in Khumbu Valley, Nepal

Traditional socio-cultural utilization and harvesting practices of an alpine medicinal herb, Neopicrorhiza scrophulariiflora in Khumbu Valley, Nepal

The biology of medicinal resource substitution in Salvia

The Biology of Medicinal Resource Substitution in Salvia

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