Brain and Spinal Tumors - Primary and Secondary 2020
DOI: 10.5772/intechopen.84726
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Neoplastic Brain, Glioblastoma, and Immunotherapy

Abstract: IGF-I, insulin-like growth factor 1, is present in normal fetal/neonatal brain development and reappears in the mature brain participating in the development of malignant tumor, glioblastoma multiforme. Targeting the IGF-I system has emerged as a useful method to reduce glial malignant development. Downregulation in the expression of IGF-I using antigene anti-IGF-I technology (antisense, AS, and triple helix, TH) applied in glioma cell culture established from glioblastoma biopsies induces the expression of B7… Show more

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Cited by 5 publications
(2 citation statements)
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References 119 publications
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“…The HDF and PRF methods ranked some nodes as important, such as APOH, FBLN5, AFP, and MMP12. Although these proteins are not present in the studied pathway, their association with GBM was previously discovered in transcriptomic or proteomic studies ( Varma Polisetty et al, 2012 ; Kros et al, 2015 ; Trojan et al, 2020 ).…”
Section: Resultsmentioning
confidence: 95%
“…The HDF and PRF methods ranked some nodes as important, such as APOH, FBLN5, AFP, and MMP12. Although these proteins are not present in the studied pathway, their association with GBM was previously discovered in transcriptomic or proteomic studies ( Varma Polisetty et al, 2012 ; Kros et al, 2015 ; Trojan et al, 2020 ).…”
Section: Resultsmentioning
confidence: 95%
“…A observação e análise de indicadores anteriores ao contexto atual é relevante, visto que é dessa análise que pode-se compreender a situação atual e pensar na estruturação futura da empresa. Os indicadores ilustram o cenário da empresa, e também a sua rentabilidade e liquidez, por tanto, tornando possível uma perspectiva geral das organizações (Silva, 2015) Essas reflexões acerca do passado, presente e futuro da empresa possibilitam a comparação dos níveis de retorno e de riscos em diversos períodos, contribuindo para a tomada de decisão (Trojan et al 2020). Diante desse contexto, evidencia-se que os indicadores de desempenho são relevantes e importantes ferramentas utilizadas para traçar o planejamento estratégico da organização e mensurar o desempenho (Fischmann & Zilber, 2000).…”
Section: Desempenho De Organizaçõesunclassified