Neoplastic Risk Among Workers Exposed to Vinyl Chloride

Waxweiler, Richard J.; Stringer, William; Wagoner, Joseph K.; Jones, James H.; Falk, Henry; Carter, Coleman

doi:10.1111/j.1749-6632.1976.tb23091.x

Cited by 183 publications

(47 citation statements)

References 18 publications

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“…These results are at odds with earlier data suggesting a positive association. Some of the populations in which increased mortality from lung cancer or an increased incidence of lung cancer was reported have been included in either the European multicenter study (17,19,23) or the North American one (29,31). In figure 4, we have summarized the accumulating evidence on an association between lung cancer and vinyl chloride exposure by presenting the results of repeated meta-analyses conducted on the data reported up to each year between 1974 and 2002.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality

Boffetta¹,

Matisāne²,

Mundt³

et al. 2003

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality

Boffetta¹,

Matisāne²,

Mundt³

et al. 2003

Scand J Work Environ Health

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“…Because of the uncertainty in the literature regarding the association between VCM exposure and lung cancer and because of the diversity of occupational chemical exposures experienced by the lung cancer cases in our previous study (1), we decided to evaluate our cohort further to determine whether or not lung cancer was associated with VCM or with other chemical exposures. Thus, the following research had three objectives: (1) by using a retrospective cohort design, to determine if our previously published excess lung cancer risk among employees exposed to VCM at this synthetic plastics plant also existed for the total plant population (2) by using a case-comparand study, to determine whether an excess lung cancer risk of a particular histologic type was in force at the plant and (3) by using a serially additive expected dose model, to test whether one or more particular chemicals used at the plant were associated with either the excess risk of all or of a specific histologic type of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the following research had three objectives: (1) by using a retrospective cohort design, to determine if our previously published excess lung cancer risk among employees exposed to VCM at this synthetic plastics plant also existed for the total plant population (2) by using a case-comparand study, to determine whether an excess lung cancer risk of a particular histologic type was in force at the plant and (3) by using a serially additive expected dose model, to test whether one or more particular chemicals used at the plant were associated with either the excess risk of all or of a specific histologic type of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Excess Lung Cancer Risk in a Synthetic Chemicals Plant

Waxweiler¹,

Smith²,

Falk³

et al. 1981

Environmental Health Perspectives

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“…Waxweiler et al (5) conducted a cohort study of workers who had been exposed to VC in the U.S. Fox and Collier (7) studied U.K. workers exposed to VC. In eight factories studied, they observed a total of four liver cancer deaths as compared to 1.64 expected.…”

mentioning

confidence: 99%

Observations of the site-specific carcinogenicity of vinyl chloride to humans.

Infante¹

1981

Environ Health Perspect

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A review of epidemiologic studies of workers exposed to vinyl chloride (VC) was conducted. Some of these studies comprised small cohorts and thus were insensitive in the evaluation of carcinogenic response for sites that do not demonstrate a high relative risk. Other larger studies used methodology and design that precluded an interpretation of the results. Such limitations were acknowledged by some authors.Use of restrictive disease rubrics also lead to the submerging of sites that would have demonstrated significant excesses. For example, some investigators analyzed data for liver cancer deaths with the board category of digestive system cancer deaths, while others combined data for CNS cancer deaths with the broad cateogry of "other and unspecified cancer," and most studies analyzed information for lymphatic and hematopoietic system cancer deaths with all data combined. Only four of eight studies reviewed could demonstrate a significant excess of liver cancer among VC-exposed workers-a site confirmed in humans by 1974. In contrast, five of eight studies appear to demonstrate a significant excess of CNS cancer mortality. Workers exposed to VC also demonstrate a significant excess of mortality for lung cancer, while the data for lymphatic and hematopoietic system cancer are suggestive. Interpretation of cancer of the latter systems may have been clarified if investigators had not analyzed their data by broad disease classifications.

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Neoplastic Risk Among Workers Exposed to Vinyl Chloride

Cited by 183 publications

References 18 publications

Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality

Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality

Excess Lung Cancer Risk in a Synthetic Chemicals Plant

Observations of the site-specific carcinogenicity of vinyl chloride to humans.

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