Neopterin and Human Immunodeficiency Virus Infection

Hofmann, Bo

doi:10.1515/cclm.1993.31.4.191

Cited by 6 publications

(6 citation statements)

References 43 publications

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“…human immunodeficiency virus (HIV) infection (1)(2)(3)(4). Neopterin derived from guanosine triphosphate (GTP) is released by monocytes/macrophages upon activation by interferon-γ secreted from T cells.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a New Simple and Rapid Enzyme-Linked Immunosorbent Assay Kit for Neopterin Determination

Westermann¹,

Thiemann²,

Gerstner³

et al. 2000

CCLM

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A new commercially available enzyme-linked immunosorbent assay (ELISA) kit has been evaluated for the measurement of neopterin concentrations in serum, plasma and urine. This competitive ELISA is technically simple, requires only small sample volume and is rapid to perform. The assay procedure consists of sequential 1.5 h and 10 min room temperature incubation steps. The ELISA is accurate, sensitive, specific, and precise. Linear regression analysis of neopterin concentrations measured with the new ELISA and with an established method yielded a highly significant correlation (r = 0.99). The new assay is applicable to ELISA workstations, thus enabling determination of neopterin in large series of samples. The neopterin ELISA kit has been used in routine laboratory testing of blood donations in a blood bank.

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Section: Introductionmentioning

confidence: 99%

Evaluation of a New Simple and Rapid Enzyme-Linked Immunosorbent Assay Kit for Neopterin Determination

Westermann¹,

Thiemann²,

Gerstner³

et al. 2000

CCLM

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“…Levels have been shown to be raised early in HIV infection 30 to change earlier in infection than T cell sub-populations 31 and to correlate well with progression 18± 20 . The predictive value of either urinary or serum neopterin or B2 microglobulin varies between studies with some showing neopterin to be equal to CD4 cell counts 32 , whilst Fahey showed an advantage of CD4+ cell percentage, compared to neopterin levels 15 .…”

Section: Discussionmentioning

confidence: 99%

Urinary neopterin as a prognostic index of survival time in HIV-1 infection

Rogstad¹,

Morgan²

1998

Int J STD AIDS

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A prospective semi-longitudinal study was undertaken to determine if urinary neopterin was a predictor for survival in HIV-positive patients. One hundred and one HIV-positive subjects attending a department of genitourinary medicine over a 41-month period were included. Survival data were analysed 6 months after the end of recruitment. Ninety-two subjects were followed up for a minimum of 6 months. Survival figures at 1 and 2 years were 93% (SE 3%) and 79% (SE 5%). There was an inverse relationship between urinary neopterin excretion and 1 and 2-year survival. Two-year survival fell from 70% (SE 6%) for neopterin levels > or = 300 mmol/mol creatinine to 25% (SE 9%) for levels > or = 700 mmol/mol creatinine (P < 0.001). Urinary neopterin may be a useful non-invasive technique in predicting survival in HIV-positive patients.

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“…Inwieweit die Bestimmung des Neopterins eine Verbesserung bringt, müssen erst weitere Studien zeigen. Es ist jedoch 885 nachgewiesen, daß es zu einem Anstieg des Neopterins bereits 1 Woche nach HIV-Infektion kommt [19], also lange vor der Möglichkeit des Antikörpernachweises. Somit ergäbe sich hier eine zusätzliche Möglichkeit, die diagnostische Lücke bis zur Serokonversion zu schließen.…”

Section: Bone and Tissue Bank -Hiv Infection -Hepatitis-c Infectionunclassified

Die Organisation einer Knochen- und Gewebebank

Regel

Lobenhoffer

et al. 1996

Der Unfallchirurg

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The use of non-treated cryopreserved bone allografts has been criticized following the publication of new cases of HIV and hepatitis-C infection caused by such grafts. However, the "new" cases of HIV infection arose in 1984/1985. when HIV testing was not possible. A critical analysis of the German bone bank procedures shows that the official guidelines are not adequate. Furthermore, new sterilization techniques are propagated for clinical use. This leads to a false feeling of security, and does not help to solve the problem of virus transmission by way of bone allografts. It is therefore essential that new guidelines for bone bank management be developed as a matter of urgency, with due consideration for everything known about this problem to date. Our current bone bank procedure is presented and the various points in the official guidelines that need updating are discussed, including the necessity for 6-month HIV and hepatitis testing modified donor screening, and special guidelines for multiple organ donors.

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Neopterin and Human Immunodeficiency Virus Infection

Cited by 6 publications

References 43 publications

Evaluation of a New Simple and Rapid Enzyme-Linked Immunosorbent Assay Kit for Neopterin Determination

Evaluation of a New Simple and Rapid Enzyme-Linked Immunosorbent Assay Kit for Neopterin Determination

Urinary neopterin as a prognostic index of survival time in HIV-1 infection

Die Organisation einer Knochen- und Gewebebank

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