Neopterin as a potential cytoprotective brain molecule

Ghisoni, Karina; Martins, Roberta de Paula; Barbeito, Luis; Latini, Alexandra

doi:10.1016/j.jpsychires.2015.10.003

Cited by 52 publications

(53 citation statements)

References 67 publications

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“…Npt is brain‐derived and not associated with blood‐brain barrier dysfunction 29. The CSF Npt concentration is greatly higher than the serum Npt concentration 29, 37, 38. Moreover, serum Npt concentration cannot be used in place of CSF Npt concentration for the diagnosis of PCNSL, as the serum Npt concentration is affected by many factors such as viral or bacterial infection and renal diseases 19.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

et al. 2018

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This study aimed at evaluating the diagnostic and prognostic role of neopterin (Npt) concentration in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma (PCNSL). Ninety‐nine patients were enrolled in this retrospective study; these included patients with PCNSL (n = 21), other brain tumors (n = 44), and inflammatory diseases (n = 34). CSF Npt concentration was measured using ELISA. Receiver operating characteristic (ROC) curve analysis was performed to assess the discriminative ability of CSF Npt concentration for the diagnosis of PCNSL. CSF Npt concentration in patients with PCNSL was significantly higher than that in patients with other brain tumors and inflammatory diseases (P < .001). On ROC curve analysis, the optimal cutoff CSF Npt level of 10.77 ng/mL for the diagnosis of PCNSL and the diagnostic yield of MRI were increased when used in conjunction with CSF Npt concentration. The CSF Npt concentrations in PCNSL patients with multiple lesions were significantly higher than those in patients with a single lesion. Changes in CSF Npt concentration were consistent with post‐treatment changes in tumor sizes. The CSF Npt concentration may be a good biomarker for the diagnosis, for monitoring of disease course, and for prognostic evaluation of patients with PCNSL.

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Section: Discussionmentioning

confidence: 99%

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

et al. 2018

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“…The clinical biochemical data were determined in a biochemical autoanalyser Dimension RxL (Siemens Healthcare Diagnostics Inc., EUA). Neopterin concentrations were determined by high-performance liquid chromatography coupled with fluorescence detection as previously reported by our group [8,9], and values were expressed as µmol/L. AGEs were measured by fluorimetry (Tecan, Grödig/ Salzburg, Austria), as previously reported [10].…”

Section: Methodsmentioning

confidence: 99%

Blood advanced glycation end products and biomarkers of inflammation in class III obese Brazilian subjects

Silva¹,

Linhares²,

Remor³

et al. 2017

Integr Obesity Diabetes

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“…Control animals received vehicle injections (saline; i.p.). The LPS dosage was selected due to the already known proinflammatory cytokine response in the adult mice brains (Henry et al, 2009;Ghisoni et al, 2015;de Paula Martins et al, 2018). Behavioral tests were performed 4 h after LPS administration.…”

Section: Lps-induced Neuroinflammationmentioning

confidence: 99%

De novo tetrahydrobiopterin biosynthesis is impaired in the inflammed striatum of parkin^(−/−) mice

Martins

Glaser

Aguiar

et al. 2018

Cell Biology International

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Parkinson's disease (PD), the second-most prevalent neurodegenerative disease, is primarily characterized by neurodegeneration in the substantia nigra pars compacta, resulting in motor impairment. Loss-of-function mutations in parkin are the major cause of the early onset familial form of the disease. Although rodents deficient in parkin (parkin ) have some dopaminergic system dysfunction associated with central oxidative stress and energy metabolism deficiencies, these animals only display nigrostriatal pathway degeneration under inflammatory conditions. This study investigated the impact of the inflammatory stimulus induced by lypopolisaccharide (LPS) on tetrahydrobiopterin (BH4) synthesizing enzymes (de novo and salvage pathways), since this cofactor is essential for dopamine synthesis. The mitochondrial content and architecture was investigated in the striatum of LPS-exposed parkin mice. As expected, the LPS (0.33 mg/kg; i.p.) challenge compromised spontaneous locomotion and social interaction with juvenile parkin and WT mice. Moreover, the genotype impacted the kinetics of the investigation of the juvenile. The inflammatory scenario did not induce apparent changes in mitochondrial ultrastructure; however, it increased the quantity of mitochondria, which were of smaller size, and provoked the perinuclear distribution of the organelle. Furthermore, the BH4 de novo biosynthetic pathway failed to be up-regulated in the LPS challenge, a well-known stimulus for its activation. The LPS treatment increased sepiapterin reductase (SPR) expression, suggesting compensation by the salvage pathway. This might indicate that dopamine synthesis is compromised in parkin mice under inflammatory conditions. Finally, this scenario impaired the striatal expression of the transcription factor BDNF, possibly favoring cell death.

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Neopterin as a potential cytoprotective brain molecule

Cited by 52 publications

References 67 publications

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

Blood advanced glycation end products and biomarkers of inflammation in class III obese Brazilian subjects

De novo tetrahydrobiopterin biosynthesis is impaired in the inflammed striatum of parkin^(−/−) mice

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Neopterin as a potential cytoprotective brain molecule

Cited by 52 publications

References 67 publications

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

Blood advanced glycation end products and biomarkers of inflammation in class III obese Brazilian subjects

De novo tetrahydrobiopterin biosynthesis is impaired in the inflammed striatum of parkin(−/−) mice

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De novo tetrahydrobiopterin biosynthesis is impaired in the inflammed striatum of parkin^(−/−) mice