1999
DOI: 10.1093/ndt/14.2.348
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Neovasularization at the vascular pole region in diabetic glomerulopathy

Abstract: The vascular abnormality localized to the vascular pole region is observed occasionally in the normal kidney, but the frequency is increased in patients with diabetic glomerulopathy. The abnormality may develop as a consequence of a long-standing diabetic glomerulopathy and might lead to less pronounced elevation of albumin excretion.

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Cited by 49 publications
(43 citation statements)
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“…Bohle and colleagues 45 found increases in vascular disease associate with more severe glomerular disease. Osterby et al 52 use a so-called "matrix to media ratio" to investigate the role of arteriosclerosis and find this ratio is increased in patients with microalbuminuria, suggesting that arteriolar matrix accumulation occurs early in the course of DN. In Table 2 we score the most severely affected artery in the biopsy and assign a score of 0 if no intimal thickening is present, 1 if intimal thickening is less than the thickness of the media, and 2 if intimal thickening is more than the thickness of the media.…”
Section: Vascular Lesionsmentioning
confidence: 99%
“…Bohle and colleagues 45 found increases in vascular disease associate with more severe glomerular disease. Osterby et al 52 use a so-called "matrix to media ratio" to investigate the role of arteriosclerosis and find this ratio is increased in patients with microalbuminuria, suggesting that arteriolar matrix accumulation occurs early in the course of DN. In Table 2 we score the most severely affected artery in the biopsy and assign a score of 0 if no intimal thickening is present, 1 if intimal thickening is less than the thickness of the media, and 2 if intimal thickening is more than the thickness of the media.…”
Section: Vascular Lesionsmentioning
confidence: 99%
“…Although the mesangial cells and podocytes are proposed as the major mediators of diabetic nephropathy, diabetic-induced microvasculature injury also plays a key role in the pathogenesis. Similar to diabetic retinopathy, increased density of glomerular capillaries, resulting from glomerular neovascularization, and increased number of efferent arterioles at the glomerular vascular pole have been seen in biopsies of patients with type 1 diabetes (4,5). In addition, there is increased glomerular expression of vascular growth factors, including angiopoietins and vascular endothelial growth factor (VEGF) (5)(6)(7), that likely contribute to diabetic nephropathy by promoting vessel leakage and reducing transendothelial electrical resistance (6,8).…”
mentioning
confidence: 98%
“…20 Hypothetically, angiogenic factors could underlie the peculiar neovascularization that is observed in glomerular nodules and about the glomerular hilus in ING and diabetes. 6,21 Vascular endothelial growth factor is expressed in podocytes and is upregulated in diabetes. 22 Vascular endothelial growth factor may promote albuminuria and GBM thickening in diabetic nephropathy by induction of endothelium-dependent vasodilation and dysregulation of type IV collagen production.…”
mentioning
confidence: 99%