Nepeta angustifolia C. Y. Wu improves renal injury in HFD/STZ-induced diabetic nephropathy and inhibits oxidative stress-induced apoptosis of mesangial cells

Huang, Shan; Tan, Meng H.; Guo, Feng; Dong, Linsha; Liu, Zhiming; Yuan, Ruiying; Dongzhi, Zhuoma; Lee, Dong-Sung; Wang, Yuefei; Li, Bin

doi:10.1016/j.jep.2020.112771

Cited by 31 publications

(16 citation statements)

References 31 publications

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“…Meinhardt et al evaluated the olfactory mucosa/nerves/tracts in patients with COVID-19 portmortem and found the highest levels of viral RNA for SARS-CoV-2 in the olfactory mucosa directly beneath the cribriform plate for 20 out of 30 patients [61] . Using magnetic resonance microscopy, histopathological evaluation and immunohistochemical analysis, Lee et al observed multifocal microvascular injury in the olfactory bulbs of postmortem patients with COVID-19 without evidence of viral infection [62] . Additional neuropathology studies, which incorporate both premortem clinical data, neuroimaging and CSF results, are needed.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid from COVID-19 patients with olfactory/gustatory dysfunction: A review

Lewis

Frontera

Placantonakis

et al. 2021

Clinical Neurology and Neurosurgery

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Objective We reviewed the literature on cerebrospinal fluid (CSF) testing in patients with altered olfactory/gustatory function due to COVID-19 for evidence of viral neuroinvasion. Methods We performed a systematic review of Medline and Embase to identify publications that described at least one patient with COVID-19 who had altered olfactory/gustatory function and had CSF testing performed. The search ranged from December 1, 2019 to November 18, 2020. Results: We identified 51 publications that described 70 patients who met inclusion criteria. Of 51 patients who had CSF SARS-CoV-2 PCR testing, 3 (6%) patients had positive results and 1 (2%) patient had indeterminate results. Cycle threshold (Ct; the number of amplification cycles required for the target gene to exceed the threshold, which is inversely related to viral load) was not provided for the patients with a positive PCR. The patient with indeterminate results had a Ct of 37 initially, then no evidence of SARS-CoV-2 RNA on repeat testing. Of 6 patients who had CSF SARS-CoV-2 antibody testing, 3 (50%) were positive. Testing to distinguish intrathecal antibody synthesis from transudation of antibodies to the CSF via breakdown of the blood-brain barrier was performed in 1/3 (33%) patients; this demonstrated antibody transmission to the CSF via transudation. Conclusion Detection of SARS-CoV-2 in CSF via PCR or evaluation for intrathecal antibody synthesis appears to be rare in patients with altered olfactory/gustatory function. While pathology studies are needed, our review suggests it is unlikely that these symptoms are related to viral neuroinvasion.

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Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid from COVID-19 patients with olfactory/gustatory dysfunction: A review

Lewis

Frontera

Placantonakis

et al. 2021

Clinical Neurology and Neurosurgery

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“…Nepeta angustifolia C. Y. Wu, an important medicinal material constituting a variety of traditional Chinese medicine prescription, has significant antioxidant activity [ 98 ]. Nepeta angustifolia C. Y. Wu inhibits proinflammatory mediators and renal oxidative stress in diabetic rats, as well as improves mitochondrial potential to disrupt mesangial cell apoptosis caused by oxidative stress in vitro [ 23 ]. AMPK is an energy sensor in metabolic homeostasis [ 99 ].…”

Section: The Modulation Of Mitochondrial Ros: the Effect Of Herb Medicine In Dnmentioning

confidence: 99%

Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities

Zhang

Zhou

Guo

et al. 2021

Journal of Diabetes Research

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Diabetic nephropathy (DN) is a progressive microvascular diabetic complication. Growing evidence shows that persistent mitochondrial dysfunction contributes to the progression of renal diseases, including DN, as it alters mitochondrial homeostasis and, in turn, affects normal kidney function. Pharmacological regulation of mitochondrial networking is a promising therapeutic strategy for preventing and restoring renal function in DN. In this review, we have surveyed recent advances in elucidating the mitochondrial networking and signaling pathways in physiological and pathological contexts. Additionally, we have considered the contributions of nontraditional therapy that ameliorate mitochondrial dysfunction and discussed their molecular mechanism, highlighting the potential value of nontraditional therapies, such as herbal medicine and lifestyle interventions, in therapeutic interventions for DN. The generation of new insights using mitochondrial networking will facilitate further investigations on nontraditional therapies for DN.

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“…Oxidative stress has been confirmed as a predominant pathogenesis for diabetes, and hyperglycemia is a primary risk factor for promoting the production of reactive oxygen species (ROS). There are multiple kinds of ROS, such as superoxide anion (O 2− ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH − ), nitrogen dioxide (NO 2 ) and nitric oxide (NO) free radicals, and so on [25]. A series of antioxidant in the normal body, include vitamin A, vitamin C, vitamin E, GSH, superoxide dismutase (SOD), GSH-Px, and GSH-R, etc., [26].…”

Section: Nano-drug Design Based On the Role Of Gsh In Oxidative Stressmentioning

confidence: 99%

Nano-Drug Design Based on the Physiological Properties of Glutathione

2021

Molecules

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Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.

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Nepeta angustifolia C. Y. Wu improves renal injury in HFD/STZ-induced diabetic nephropathy and inhibits oxidative stress-induced apoptosis of mesangial cells

Cited by 31 publications

References 31 publications

Cerebrospinal fluid from COVID-19 patients with olfactory/gustatory dysfunction: A review

Cerebrospinal fluid from COVID-19 patients with olfactory/gustatory dysfunction: A review

Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities

Nano-Drug Design Based on the Physiological Properties of Glutathione

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