Nephroblastoma with Transcoelomic Metastasis in a Japanese Black Bull

Yamamoto, Yu; Yamada, Manabu; Nakamura, Kikuyasu; Takahashi, Yûji; Miyamoto, Toru

doi:10.1292/jvms.68.891

Cited by 5 publications

(11 citation statements)

References 10 publications

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“…In a case reported with pulmonary metastasis, mesenchymal stroma was scanty and consisted of thin bundles, which penetrated the neoplastic epithelial tissue (SCAGLIONE et al, 2012). Yamamoto et al (2006) also found that epithelial elements were rare in metastatic nodules, which were composed mainly of blastema and stromal elements, as observed during this investigation.…”

Section: Introductionsupporting

confidence: 87%

“…Instead, in this report we found in this case that the blastema cells were negative for cytokeratin and vimentin, which is in agreement with Castiglioni et al (2013), and marked positive for S100. The mesenchymal cells are marked positive for vimentin and smooth muscle actin, which is in agreement with Yamamoto et al (2006), which may demonstrate that these cells are differentiating into smooth muscle tissue (CASTIGLIONI et al, 2013).…”

Section: Introductionsupporting

confidence: 69%

“…Nephroblastoma is the most common primary renal neoplasm of swine and chicken (MEUTEN, 2002), and more recently has also been reported in cattle, mostly in fetus, in which it was associated with dystocia in cows and buffalo during calving (DEVI et al, 2011;MADHESWARAN et al, 2014); cases have also been described a few in adult cattle (YAMAMOTO et al, 2006;SCAGLIONE et al, 2012), and there is no apparent breed predisposition. This tumor has been occasionally reported in horses (JARDINE; NESBIT, 1996), sheep (HEADLEY et al, 2006) and dogs (MONTINARO et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The stromal element is composed of spindle cells revealing positive immunostaining for vimentin, smooth muscle actin and desmin; epithelial component is marked positive for cytokeratin; while blastema cells are mildly positive for cytokeratin (YAMAMOTO et al, 2006) and vimentin (SCAGLIONE et al, 2012). Instead, in this report we found in this case that the blastema cells were negative for cytokeratin and vimentin, which is in agreement with Castiglioni et al (2013), and marked positive for S100.…”

Section: Introductionmentioning

confidence: 99%

“…Transcelomic metastasis to the lungs was described by Yamamoto et al (2006) in a bull. However, herein we described based on histopathology that metastasis most likely occurred through lymphatic vessels than transcelomical, because blastema neoplastic cells were observed within lymphatic vessels on the lungs.…”

Section: Introductionmentioning

confidence: 99%

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Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Bianchi

Konradt

Leite-Filho

et al. 2017

SCA

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Nephroblastoma is a congenital renal neoplasm composed of metanephric blastema and stromal cells. A one-year-old male Angus calf presented with diarrhea, nasal discharge, cough and weight loss. Serum levels of creatinine and urea were increased, with reduction in the level of albumin. After eight days, clinical condition got worse and the calf died. On necropsy, the cranial pole of the left kidney presented a firm whitish mass (30 x 21 x 14 cm). Multifocal to coalescing firm whitish nodules were observed on the serosa of the large intestine, in the mesentery and in the adventitia of the urinary bladder. All lung lobes contained multifocal to coalescing firm whitish elevated nodules (0.5 to 1 cm of diameter). Histologically, renal mass consisted of neoplastic proliferation of embryonal epithelial and mesenchymal cells, intermixed with large amounts of blastema cells. The nodules on large intestine, mesentery, urinary bladder and lungs were composed mainly of blastema cells and mild amount of mesenchymal cells. Blastema cells were also observed within lymphatic vessels in lung parenchyma. Embryonal epithelial, mesenchymal and blastema cells showed, respectively, positive immunostain for cytokeratin, vimentin and S100. Based on pathological and immunohistochemical findings, the tumor was diagnosed as nephroblastoma in a calf with metastasis through lymphatic vessels to lungs, large intestine, mesentery and urinary bladder. Key words: Cattle. Congenital. Neoplasm. Nephroblastoma. ResumoO nefroblastoma é uma neoplasia renal congênita composta por um blastema metanéfrico e células estromais. Um bezerro Angus, macho, de um ano de idade apresentou diarreia, descarga nasal, tosse e perda de peso. Os níveis de creatinina e ureia estavam aumentados, com albumina diminuída. Após oito dias, a condição clínica piorou e o bezerro veio a óbito. Na necropsia, o polo cranial do rim esquerdo apresentou uma massa brancacenta firme (30 x 21 x 14 cm). Nódulos brancacentos firmes multifocais a coalescentes foram visualizados na serosa do intestino grosso, mesentério e adventícia da bexiga. Nos pulmões nódulos elevados brancacentos firmes (0.5 a 1 cm de diâmetro) multifocais a coalescentes foram observados. Histologicamente, a massa no rim consistia em proliferação neoplásica de células embrionais epiteliais e mesenquimais, entremeadas a grande quantidade de células blastemais. Os nódulos no intestino grosso, mesentério, bexiga e pulmões eram compostos principalmente por células

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Section: Introductionsupporting

confidence: 87%

Section: Introductionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Bianchi

Konradt

Leite-Filho

et al. 2017

SCA

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Experimental determination of shear stresses on an artificial transcoelomic metastasis model using optical tweezers: A comparison with numerical simulation

2022

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Background: One of the reported pathways of cancer spread is the transcoelomic pathway, which is understood as the spread of cancer cells in the abdominal and thoracic cavities through interstitial fluid. It has been proven that the shear stresses caused by microfluidic currents on cancer tumors in the abdominal and thoracic cavities cause the detachment of cancer cells triggering transcoelomic metastasis; however, the magnitude of shear stresses has not yet been measured experimentally.Objectives: The objective of this study is to develop an experimental methodology using optical tweezers to approximate the shear stresses suffered by a nonporous, rigid artificial cancerous nodule model. Methods: Artificial cancerous nodule model was made by the agglomeration of 2 μm diameter polystyrene particles in a microfluidic platform. Optical tweezers were used as a velocimetry tool and shear stresses on the surface of the nodule model were approximated with the viscous shear stress equation. The results were verified with a numerical simulation performed in Ansys Fluent. Results: Shear stress originated by microflow over artificial cancerous nodule model were quantified both experimentally and numerically, showing good agreement between both methods. Such stress on the nodules' surface was much greater than that suffered by the wall on which the nodule model was located and dependent of the nodule model geometry. Although the experiment and simulation of this study were performed using a rigid and nonporous nodule model, the conclusion obtained about the increase of shear stresses applies to permeable, porous, and soft nodules as well, because the shear stresses are associated to the acceleration of the fluid originated by the reduction of the crosssectional area. Conclusions: Shear stress over artificial nodule model were successfully quantified using optical tweezer-based velocimetry technique and verified through numerical calculation. Advantages of experimental technique are: (1) it allows to control the position in a three-dimensional plane, allowing measurements in the vicinity of the analyzed surfaces, and (2) it is applicable for very low Reynolds number (R e « 1). On the other hand, as disadvantages: (1) it tends to be complicated to perform velocity measurements over obstacles and (2) it is limited in trapping distance.

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Immunohistochemical Characterization of a Renal Nephroblastoma in a <i>Trp</i>53-mutant and Prolyl Isomerase 1-deficient Mouse

et al. 2013

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A nephroblastoma is a tumor arising from metanephric blastema occurring in childhood. Among laboratory rodents, nephroblastoma has been frequently reported in rats, but it remains exceedingly rare in mice. The present work describes a nephroblastoma in a young mouse homozygous for the specific Trp53 R172H point mutation coupled with targeted deletion of the Pin1 gene. The affected kidney was effaced by a biphasic tumor with an epithelial component arranged in tubules surrounded by nests of blastemal cells. Immunohistochemically, the neoplasm was diffusely positive for Wilms’ tumor antigen. The epithelial component expressed markers of renal tubular differentiation including wide-spectrum cytokeratin, E-cadherin and folate-binding protein. Furthermore, the neoplasm exhibited a high proliferative index and diffuse nucleocytoplasmic β-catenin expression. Based on histological and immunohistochemical features, a diagnosis of nephroblastoma potentially associated with Trp53 loss and oncogenic β-catenin activation has been proposed.

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Nephroblastoma with Transcoelomic Metastasis in a Japanese Black Bull

Cited by 5 publications

References 10 publications

Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Experimental determination of shear stresses on an artificial transcoelomic metastasis model using optical tweezers: A comparison with numerical simulation

Immunohistochemical Characterization of a Renal Nephroblastoma in a <i>Trp</i>53-mutant and Prolyl Isomerase 1-deficient Mouse

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