Nephrocalcinosis Associated with Primary Aldosteronism

Yang, C W; Kim, S Y; Kim, Y S; Koo, Wan Suh; Choi, Eun Joo; Chang, Yun Woo; Yoon, Yong Suk; Bang, Byung Kee

doi:10.1159/000188318

Cited by 7 publications

(9 citation statements)

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“…Nephrocalcinosis associated with hyperaldosteronism is rare, with only a handful of cases described in literature [ 3 – 6 ]. Hyperaldosteronism is known to facilitate Ca + excretion in urine [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…In hyperaldosteronism, there is a reduced reabsorption of Na + from the aldosterone – insensitive tubular sites, causing subsequent hypercalciuria [ 3 ]. C.W Yang et al proposed an alternative theory for nephrocalcinosis due to hyperaldosteronism [ 6 ]. According to them, chronic hypokalemia seen in cases of hyperaldosteronism can cause a tubulointerstitial injury.…”

Section: Discussionmentioning

confidence: 99%

“…This is associated with elevated ammoniagenesis and subsequent renal damage through ammonia- activated compliment pathways. The medullary cyst formation, interstitial inflammation and medullary calcification may all be related to the ammonia- mediated nephropathy [ 6 ]. Schwedler et al proposed an alternative theory for nephrocalcinosis in chronic hypokalemic states [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…It can thus be conjectured that a chronic, long- standing hyperaldosteronic state can cause super- saturation and crystallization of calcium in the interstitium and induce nephrocalcinosis. Very few cases exist in literature linking hyperaldosteronism with nephrocalcinosis [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis

et al. 2015

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SummaryBackgroundAn association between chronic hyperaldosteronism and medullary nephrocalcinosis has rarely been made, with only a handful of cases described in literature.Case ReportWe describe five cases of hyperaldosteronism with a long- standing history in whom associated medullary nephrocalcinosis was established.ConclusionsWe infer that a chronic hyperaldosteronic status, whether primary or secondary, is a causal factor in the etiopathogenesis of medullary nephrocalcinosis. This article illustrates and summarizes various postulated theories that support our proposed association between hyperaldosteronism and nephrocalcinosis. We conclude that chronic hyperaldosteronism should be included as one of the causes of nephrocalcinosis and that our case series emphasizes the need of a well-organized retrospective study to prove it further.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis

et al. 2015

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“…Renal calculi or nephrocalcinosis associated with primary aldosteronism has been rarely reported (2)(3)(4)(5). Primary aldosteronism is reported to elevate urinary calcium excretion (10).…”

Section: Discussionmentioning

confidence: 99%

A Case of Nephrocalcinosis Associated with Primary Aldosteronism

Yasuda¹,

Sasaki²,

Yamato³

et al. 2012

Intern. Med.

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Herein, we report a 37-year-old man presenting with nephrocalcinosis associated with primary aldosteronism. Primary hyperaldosteronism is reported to facilitate urinary calcium excretion; however, renal calculi or calcinosis in this disorder has been rarely reported. The patient had renal dysfunction and calcification in the renal medulla on both kidneys. A kidney biopsy was performed. His renal dysfunction seemed to be mainly caused by hypertension and tubulointerstitial damage. Furthermore, von Kossa-positive stones were seen in some tubules. X-ray element analysis revealed that the stones were composed of calcium phosphate.

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An unusual case of recurrent hypokalemic paralysis in an adolescent: Answers

Okechuku

Upadhyay

2014

Pediatr Nephrol

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Nephrocalcinosis Associated with Primary Aldosteronism

Cited by 7 publications

References 0 publications

An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis

An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis

A Case of Nephrocalcinosis Associated with Primary Aldosteronism

An unusual case of recurrent hypokalemic paralysis in an adolescent: Answers

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