Nephrogenic Adenoma:A Rare Bladder Tumor in Children

Unique clinicopathologic and molecular characteristics of urinary bladder tumors in children and young adults

“…Although most studies indicate that NA typically occurs in adults ranging from 49 to 62 years of age [69,[72][73][74], NA does occur in pediatric patients, especially in a background of previous bladder surgery [71]. Although a male predilection is sometimes cited for adult patients, pediatric cases of NA appear to occur more commonly in females (5:1) [71,75]. Symptoms in children commonly include gross hematuria or irritative bladder symptoms.…”

“…Symptoms in children commonly include gross hematuria or irritative bladder symptoms. Recurrence of NA is common in the pediatric population (80%) [71]. Microscopically, NA exhibits architectural and cytologic complexity.…”

Recurrent nephrogenic adenoma in a 10-year-old boy with prune belly syndrome : a case presentation

“…It was first described in 1950 [2]. Incidence is highest in middle-aged males [1], although pediatric patients are more commonly female [3]. To our knowledge, this is the first reported case of nephrogenic adenoma in a patient with prune belly syndrome.…”

“…Recurrences are common. Heidenreich et al report an 80% recurrence rate in children, with peak recurrence at approximately 4 years after treatment [3]. Malignancy arising from NA has also been described in the adult literature, although no pediatric cases have been reported [4,9,10].…”

Rare cause of macroscopic hematuria in a pediatric patient: Nephrogenic adenoma of the bladder

“…Increased risk of infection and recurrence necessitates prophylactic antibiotic therapy and routine cystoscopy. Generally cystoscopy is advised to be done every 3 months for 2 years, every 6 months for 3 years and then once per year in the absence of infection or voiding complaints, but some authors have suggested that cystoscopy may itself stimulate new lesions . Also, patient compliance with recurrent cystoscopy is low; if symptoms recur, cystoscopy should be strongly suggested.…”