2007
DOI: 10.1016/j.jaad.2007.02.021
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Nephrogenic systemic fibrosis: A clinicopathologic study of six cases

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Cited by 57 publications
(35 citation statements)
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“…3,4,[12][13][14][15][16][17] In fact, some researchers have hypothesized an early link between Gd deposition and the activation of certain profibrotic enzymes, such as tissue transglutaminases. 18 Our own research group was the first to document Gd deposition within skin affected by NSF using SEM/EDS, 5 ICP-MS, 10 and now, SXRFS.…”
Section: Discussionmentioning
confidence: 99%
“…3,4,[12][13][14][15][16][17] In fact, some researchers have hypothesized an early link between Gd deposition and the activation of certain profibrotic enzymes, such as tissue transglutaminases. 18 Our own research group was the first to document Gd deposition within skin affected by NSF using SEM/EDS, 5 ICP-MS, 10 and now, SXRFS.…”
Section: Discussionmentioning
confidence: 99%
“…Skin biopsies demonstrate dermal fibrosis with a significant increase in cellularity, but no inflammation (59). Often the cells are described as being spindle shaped (61,77), fibroblasts (6), fibroblast like (56), fibrohistiocytic (68,75,82), or "polygonal epitheliod fibroblasts" (6). With the use of light microscopy, the dermal collagen is notably increased (27), with bundles haphazardly arranged (56) or "disorganized" (48).…”
Section: Histology and Immunohistologymentioning
confidence: 99%
“…1,2,4 NSF was first reported in the year 2000 as a scleromyxedema-like condition affecting patients with end-stage renal disease. 3,5 Given the association between the characteristic skin findings and presence of endstage renal disease, without an associated paraproteinemia, the disorder was named ''nephrogenic fibrosing dermopathy.'' 5,6 Postmortem studies in patients given a diagnosis of this skin disorder revealed widespread fibrosis, resulting in a change in nomenclature from ''nephrogenic fibrosing dermopathy'' to ''nephrogenic systemic fibrosis.''…”
mentioning
confidence: 99%