Nephron Prorenin Receptor Deficiency Alters Renal Medullary Endothelin-1 and Endothelin Receptor Expression

Ramkumar, Nirupama; Stuart, Deborah; Abraham, Nikita; Kohan, Donald E.

doi:10.33549/physiolres.933809

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…Therefore, Endothelin-1 is a key factor contributing to the extracellular volume and blood pressure homeostasis. Alterations of the Endothelin-1 system have been documented in renal diseases in which cardiovascular illness including hypertension and endothelial dysfunction coexist [5]. Individuals obtain vitamin D either through consuming vitamin D-rich foods (oily fish, dairy products) or supplements, or through the skin's exposure to ultraviolet B radiation producing vitamin D [6].…”

Section: Introductionmentioning

confidence: 99%

Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease

Amir¹,

Zeidan²

2019

Tikrit J. Pure Sci.

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Chronic renal disease is a worldwide public health problem with an increasing incidence, prevalence, poor outcomes, and high cost. A cross-sectional study was carried out in balad city from 10th of November 2018 to 15th of March 2019. The number of patients under study were 60 patients with renal disease (30 acute renal disease and 30 chronic renal disease under hemodialysis). Their ages were between (20-75) years. Patients with acute renal disease were admitted to Balad general hospital and patients with chronic renal disease who admitted to Salahaddin general hospital for hemodialysis. The study included 30 apparently healthy subject as control group. The results showed that the highest mean level of endothelin-1 was found in patients with chronic renal disease (13.15±7.81)pg/ml followed by patients with acute renal disease (1.78±1.49) pg/ml compared with the control group (0.41±0.31) pg/ml. These result were significant higher (P< 0.01). The results showed that the lowest mean level of vitamin D was found in patients with chronic renal disease (14.45±5.92) ng/ml followed by patients with acute renal disease (23.49±13.14) ng/ml compared with the control group (24.02 ±8.22) ng/ml. The results were significant higher than control (P≤0.01). The study showed that patients with acute renal disease were distributed equally to male and female (1:1) while 56.67% of patients with chronic renal disease were males. The conclute from this study that the endothelin elevated in chronic renal disease patients and vitamin D was reduced.

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Section: Introductionmentioning

confidence: 99%

Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease

Amir¹,

Zeidan²

2019

Tikrit J. Pure Sci.

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The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice

Mendoza

Hyndman

2019

American Journal of Physiology-Renal Physiology

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The collecting duct (CD) concentrates the urine, thereby maintaining body water volume and plasma osmolality within a normal range. The endocrine hormone arginine vasopressin acts in the CD to increase water permeability via the vasopressin 2 receptor (V2R)-aquaporin (AQP) axis. Recent studies have suggested that autocrine factors may also contribute to the regulation of CD water permeability. Nitric oxide is produced predominantly by nitric oxide synthase 1 (NOS1) in the CD and acts as a diuretic during salt loading. The present study sought to determine whether CD NOS1 regulates diuresis during changes in hydration status. Male and female control and CD NOS1 knockout (CDNOS1KO) mice were hydrated (5% sucrose water), water deprived, or acutely challenged with the V2R agonist desmopressin. In male mice, water deprivation resulted in decreased urine flow and increased plasma osmolality, copeptin concentration, and kidney AQP2 abundance independent of CD NOS1. In female control mice, water deprivation reduced urine flow, increased plasma osmolality and copeptin, but did not significantly change total AQP2; however, there was increased basolateral AQP3 localization. Surprisingly, female CDNOS1KO mice while on the sucrose water presented with symptoms of dehydration. Fibroblast growth factor 21, an endocrine regulator of sweetness preference, was significantly higher in female CDNOS1KO mice, suggesting that this was reducing their drive to drink the sucrose water. With acute desmopressin challenge, female CDNOS1KO mice failed to appropriately concentrate their urine, resulting in higher plasma osmolality than controls. In conclusion, CD NOS1 plays only a minor role in urine-concentrating mechanisms.

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Renal Autocrine and Paracrine Signaling: A Story of Self-protection

Leipziger

Praetorius

2020

Physiological Reviews

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Autocrine and paracrine signaling in the kidney adds an extra level of diversity and complexity to renal physiology. The extensive scientific production on the topic precludes easy understanding of the fundamental purpose of the vast number of molecules and systems that influence the renal function. This systematic review provides the broader pen strokes for a collected image of renal paracrine signaling. First, we recapitulate the essence of each paracrine system one by one. Thereafter the single components are merged into an overarching physiological concept. The presented survey shows that despite the diversity in the web of paracrine factors, the collected effect on renal function may not be complicated after all. In essence, paracrine activation provides an intelligent system that perceives minor perturbations and reacts with a coordinated and integrated tissue response that relieves the work load from the renal epithelia and favors diuresis and natriuresis. We suggest that the overall function of paracrine signaling is reno-protection and argue that renal paracrine signaling and self-regulation are two sides of the same coin. Thus local paracrine signaling is an intrinsic function of the kidney, and the overall renal effect of changes in blood pressure, volume load, and systemic hormones will always be tinted by its paracrine status.

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Nephron Prorenin Receptor Deficiency Alters Renal Medullary Endothelin-1 and Endothelin Receptor Expression

Cited by 4 publications

References 25 publications

Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease

Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease

The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice

Renal Autocrine and Paracrine Signaling: A Story of Self-protection

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