Nephropathy Associated with Gardner-Diamond Syndrome

McIntosh, Rawle M.; Ozawa, Takeshi; Persoff, Michael; Altshuler, John H.; Guggenheim, Stephen; Boedecker, Edward

doi:10.1056/nejm197706022962205

Cited by 17 publications

(6 citation statements)

References 7 publications

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“…Autoerythrocyte sensitization syndrome is not known to be associated with thrombotic phenomena or recurrent miscarriages. Other autoimmune diseases have been reported in association with AES 6,13 , 14 . However, these were isolated case reports and are unlikely to be of any significance.…”

Section: Discussionmentioning

confidence: 94%

Periodic painful purpura: Fact or factitious?

Vun

Muir

2004

Aust J Dermatology

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A 60-year-old woman with multiple psychosocial issues presented with a history of spontaneous painful bruising on her left upper arm. Extensive investigations did not reveal any abnormality apart from an elevated activated partial thromboplastin time as a result of factor XII deficiency. An autoerythrocyte sensitization test reproduced the tender bruises on her back. Our patient reported relief of pain with promethazine injections. She was subsequently referred to the psychiatric team for ongoing assessment and management. Having an awareness of this rare condition will assist in the prevention of unnecessary investigation of such cases and will allow the early referral of patients for appropriate psychological counselling.

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Section: Discussionmentioning

confidence: 94%

Periodic painful purpura: Fact or factitious?

Vun

Muir

2004

Aust J Dermatology

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“…Lesions are most commonly located over the arms, trunk and legs. [78] However, multiple areas can be involved at the same time. Some may also present as cellulitis or even bullous lesions.…”

Section: Discussionmentioning

confidence: 99%

Perplexing purpura in two females: Rare case of autoerythrocyte sensitization syndrome

Tainwala

Phiske

Raghuwanshi

et al. 2013

Indian Dermatol Online J

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Autoerythrocyte sensitization syndrome is a psychologically induced painful bruising condition. Two female, 19 and 30-year-old presented with recurrent episodes of painful ecchymotic bruising over accessible areas of body. In the younger female, episodes were since 3 years and were precipitated by stress and trivial trauma. The elder female presented with similar lesions since 3 months which were spontaneous in presentation. There were no obvious psychiatric manifestations in either. Clinically, ecchymotic changes in various stages of development were seen. Routine hemogram and coagulation profile were normal. Histopathology showed extravasated erythrocytes, perivascular neutrophils and fibrinoid deposition. Intradermal injection of autologous whole blood produced a painful ecchymotic reaction after 2 h similar to the presenting lesions. Psychiatric evaluation revealed mild mixed depression – anxiety disorder in the younger female while the latter revealed no abnormalities. The diagnosis of autoerythrocyte sensitization syndrome was made based on clinical history and findings, positive autoerythrocyte sensitization test, psychiatric evaluation and absence of any other clinical or laboratory pathology.

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“…Le syndrome de Gardner-Diamond a été décrit en association avec certaines maladies auto-immunes ou inflammatoires [4][5][6][7][8] : lupus érythémateux disséminé [4], néphrite à complexes immuns [5], hypocomplémentémie [6], purpura thrombopénique idiopathique [7], adénopathie angio-immunoplastique [6] et présence d'anticorps anticardiolipine [8]. Ratnoff a décrit les lésions du syndrome de Gardner-Diamond comme des ecchymoses inflammatoires [2].…”

Section: Discussionunclassified

“…* Bien que le syndrome de Gardner-Diamond ne soit pas classé parmi les affections auto-inflammatoires, on peut y observer des signes immuno-inflammatoires [4][5][6][7][8]. Nous décrivons une observation de vascularite cutanée chez une femme qui avait un syndrome de Gardner-Diamond et nous passons brièvement en revue les signes inflammatoires qui peuvent accompagner cette affection.…”

Section: Introductionunclassified