2021
DOI: 10.7324/japs.2021.1101016
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Nephroprotective activity of medicinal plants: A review on in silico-, in vitro-, and in vivo-based studies

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Cited by 15 publications
(14 citation statements)
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“…The kidneys play an important role in human physiology, maintaining fluid homeostasis, regulating blood pressure, erythrocyte production and bone density, regulating hormonal balance, and filtering and removing nitrogenous and other waste products [ 1 , 2 ]. Chronic kidney disease (CKD) is characterized by a progressive loss of functions while acute kidney injury (AKI) is an abrupt reduction in kidney function.…”
Section: Introductionmentioning
confidence: 99%
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“…The kidneys play an important role in human physiology, maintaining fluid homeostasis, regulating blood pressure, erythrocyte production and bone density, regulating hormonal balance, and filtering and removing nitrogenous and other waste products [ 1 , 2 ]. Chronic kidney disease (CKD) is characterized by a progressive loss of functions while acute kidney injury (AKI) is an abrupt reduction in kidney function.…”
Section: Introductionmentioning
confidence: 99%
“…Chronic kidney disease (CKD) is characterized by a progressive loss of functions while acute kidney injury (AKI) is an abrupt reduction in kidney function. Both CKD and AKI have increased worldwide and are considered one of the leading public health problems [ 2 , 3 ]. A projection of health concerns by 2040 ranked CKD as the fifth leading cause of death worldwide [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…26 Antioksidan telah terbukti efektif dalam menangkal ROS, serta bertanggungjawab dalam berbagai aktivitas biologis yang bermanfaat. 26,27 Keberadaan gugus hidroksil sangat mempengaruhi efek penghambatan atau mempengaruhi interaksi flavonoid dengan jalur katalitik xantin oxidase. Selain itu, mekanisme polifenol dalam menghambat xantin oxidase dengan cara mengikat sisi aktif dan memblok masuknya xanthine dan pelepasan asam urat dan serta difusi radikal bebas.…”
Section: Pembahasanunclassified
“…The normal function of the kidneys is affected by inorganic metals such as mercury, thallium, barium, and bismuth, as well as non-steroidal antiinflammatory drugs (NSAIDs) like ibuprofen, indomethacin, and aspirin, as well as organic solvents like carbon tetra chloride and toluene, anticancer drugs, aminoglycoside antibiotics, and some antimicrobial agents (8). Nephrological problems can be attributed to a lack of oxygen and nutrients as a result of an inadequate supply of oxygen and nutrients to the kidneys and an increase in energy requirements as a result of oxidative stress (9,10). Medicinal herbal products are becoming increasingly popular around the world as a way of treating acute and chronic kidney illness (11).…”
Section: Introductionmentioning
confidence: 99%