Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure

Shebeko, S. K.; Chernykh, V. V.; Zupanets, K. O.

doi:10.3390/scipharm88040047

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…The herbal combination BNO 2103 is known to be efficacious for treating urogenital infections in humans by impeding the adhesion of pathogens in the urogenital tract, as well as having spasmolytic, diuretic, anti-oxidative, anti-inflammatory, and anti-nociceptive effects that contribute to the successful treatment [ 82 , 136 , 138 , 139 , 140 , 141 , 142 , 143 ]. Further, in contrast to antibiotics and NSAIDs, herbal medical products are thought to preserve the gut microbiome.…”

Section: Preservation Of the Gut Microbiome Under Bno 2103: Results I...mentioning

confidence: 99%

Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health

et al. 2022

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Epithelial surfaces in humans are home to symbiotic microbes (i.e., microbiota) that influence the defensive function against pathogens, depending on the health of the microbiota. Healthy microbiota contribute to the well-being of their host, in general (e.g., via the gut–brain axis), and their respective anatomical site, in particular (e.g., oral, urogenital, skin, or respiratory microbiota). Despite efforts towards a more responsible use of antibiotics, they are often prescribed for uncomplicated, self-limiting infections and can have a substantial negative impact on the gut microbiota. Treatment alternatives, such as non-steroidal anti-inflammatory drugs, may also influence the microbiota; thus, they can have lasting adverse effects. Herbal drugs offer a generally safe treatment option for uncomplicated infections of the urinary or respiratory tract. Additionally, their microbiota preserving properties allow for a more appropriate therapy of uncomplicated infections, without contributing to an increase in antibiotic resistance or disturbing the gut microbiota. Here, herbal treatments may be a more appropriate therapy, with a generally favorable safety profile.

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Section: Preservation Of the Gut Microbiome Under Bno 2103: Results I...mentioning

confidence: 99%

Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health

et al. 2022

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“…The second task was to examine the AIA of the active ingredients of the test drug in the model of phlogogen -induced paw inflammation in rats. According to the study results in the model of RF using laboratory and histomorphological methods, it was proved that the composition BNO 2103 has nephroprotective, diuretic, hypoazotemic and antiproteinuric effects and is superior to comparator drugs in most respects [25]. This article presents the results of the second stage of the study -to examine the anti-inflammatory activity of the test drug.…”

Section: оригінальні дослідженняmentioning

confidence: 98%

Effect of phytoneering remedy BNO 2103 on the course of experimental exudative inflammation caused by different phlogogens

Chernykh

Зупанец

Shebeko

2022

ZMJ

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Kidney and urinary tract diseases play an important role in the disease distribution in most countries of the world. The pharmaceutical industry offers many means for the treatment and prevention of these diseases, but there is a trending tendency to pay more attention to herbal medicines, their empirical application and scientific study. The aim of this research is to study anti-inflammatory properties of standardized herbal composition BNO 2103 in a model of paw inflammation in rats caused by different phlogogens to justify the use of it in the treatment of chronic kidney disease (CKD). Materials and methods. The experimental study was performed using 90 male white outbreed rats weighing 150–200 g, which were divided into 3 series of 30 animals each, each series included 3 groups. Inflammation of the paw was induced by subplantar administration of phlogogens – zymosan, histamine and serotonin. The study agent and the reference drug, diclofenac sodium, were administered intragastrically (i. g.) once. Edema was observed and recorded, and anti-inflammatory activity (AIA) was assessed in 0.5, 1.0, 2.0, 3.0 and 6.0 hours after phlogogen injection. Results. BNO 2103 showed a remarkable anti-exudative effect in the model of zymosan and histamine edema, being significantly superior to diclofenac sodium. In the serotonin edema model, BNO 2103 was significantly superior to the comparator by the endpoints, showing the moderate but prolonged anti-exudative effect. Conclusions. BNO 2103 has the significant anti-inflammatory effect, exerting an inhibitory effect on exudative inflammation caused by various phlogogens (zymosan, histamine, serotonin), mainly acting on the lipoxygenase pathway of arachidonic acid conversion, which is most likely due to the presence of flavonoids. This allows us to consider BNO 2103 as a promising drug for the treatment of CKD.

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“…Along with the conventional medication, phytotherapeutic agents (for example polyphenols) are effectively used for the symptomatic treatment of renal failure [11,12].…”

Section: Introductionmentioning

confidence: 99%

Interactions of Bioflavonoid Robinin With Efflux Transporters: P-Glycoprotein and Breast Cancer Resistance Protein

Tsiklauri

Alania

et al. 2023

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Present study investigated the possible role of P-glycoprotein in the intracellular exposure of active substance (robinin) of natural medicine Flaroninum™ and effect of robinin on the cellular accumulation of mitoxantrone in either BCRP-overexpressing and BCRP-negative cells.Robinin -kaempferol-3-O--D-robinoside-7-O-α-L-rhamnopyranoside, has been obtained from over ground parts of Astragalus falcatus Lam., growing in Georgia. The compound possesses hypoazotemic and diuretic activities and is proposed for the complex therapy of kidney diseases. Pgp-overexpressing and P-gp-negative human breast cancer cells (MCF7) were used to examine the absorption character of kaempferol and robinin with or without of verapamil (P-gp inhibitor).Flavonoids concentrations were determined by LC/MS/MS. Robinin transport was P-gp-dependent and verapamil significantly increased the extent of uptake of robinin in cells, which is attributed in part to P-gp-inhibition by verapamil. When comparing the intracellular accumulation of aglycone with kaempferol-3-O--D-robinoside-7-O-α-L-rhamnopyranoside, we found that kaempferol uptake was greater than robinin. Since some glycosylated forms of flavonoids have been demonstrated to significantly suppress breast cancer resistance protein (BCRP/ABCG2), we hypothesized that kaempferol-3-O--D-robinoside-7-O-α-L-rhamnopyranoside may act as a BCRP-inhibitor. Mitoxantrone accumulation studies were performed in BCRP-overexpressing and BCRP-negative MCF7 cells using flow cytometric analysis. Robinin (5 and 50 M) had no significant impacts on the BCRP-mediated mitoxantrone transport; on the contrary, the aglycone kaempferol produced increased accumulation of mitoxantrone. From these results, we suggest that the active component of natural hypoazotemic medicine Flaroninum™, robinin, may be a substrate of P-gp and its efflux outside of the cells mediated P-gp may contribute to its decreased intracellular concentration.

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Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure

Cited by 7 publications

References 30 publications

Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health

Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health

Effect of phytoneering remedy BNO 2103 on the course of experimental exudative inflammation caused by different phlogogens

Interactions of Bioflavonoid Robinin With Efflux Transporters: P-Glycoprotein and Breast Cancer Resistance Protein

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