Nephrotic syndrome and acute kidney injury following CoronaVac anti-SARS-CoV-2 vaccine

Abstract

A 67-year-old female with type 2 diabetes mellitus developed nephrotic syndrome with in one week of receiving the first dose of SARS-CoV-2 CoronaVac vaccine. A kidney biopsy was consistent with minimal change nephrotic syndrome and treatment was symptomatic with antiproteinurik therapy and improvement in proteinuria. Edema returned within one week of the second dose of CoronaVac. In this occasion acute kidney injury and massive proteinuria were noted. In kidney biopsy, glomeruli were normal, but tubulointerstitial inflammation consistent with acute tubulointerstitial nephritis were noted. Pulse followed by oral steroids were followed by recovery of kidney function. Proteinuria decreased after initiation of cyclosporine A.

Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review

“…After that, additional 85 articles were identified from other resources. Finally, 464 studies were included for qualitative and quantitative analysis [ 11 ], [ [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , ...…”

Minimal change disease and COVID-19 vaccination: Four cases and review of literature

“…One patient had spontaneous remission which is uncommon but is described in MCD. Spontaneous improvement was also noted in 2 cases after COVID-19 vaccine after the first dose (Unver et al [ 25 ], Marinaki et al [ 28 ]); however, both times, symptoms relapsed after the 2 nd dose, and the patient then required immunosuppression.…”

New-onset and relapse of nephrotic syndrome following COVID-19 vaccination: a questionnaire survey in Japan

“…Acute kidney injury (AKI) is an important and consistent feature that has been reported in most cases of new-onset and relapse of NS following COVID-19 vaccination [ 8 – 11 ]. Although a causal association cannot be confirmed definitively, clinicians and pathologists should be aware that NS is a potential adverse effect of the vaccines.…”