Nephrotic syndrome associated with human parvovirus B19 infection

Ohtomo, Yoshiyuki; Kawamura, Risako; Kaneko, Kazunari; Yamashiro, Yuichiro; Kiyokawa, Nobutaka; Taguchi, Tomoko; Mimori, Kenichi; Fujimoto, Junichiro

doi:10.1007/s00467-002-1056-2

Cited by 34 publications

(16 citation statements)

References 18 publications

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“…In some but not all cases studied, parvovirus antigens were localized to glomerular cells that were not further characterized [19, 23], but were entirely absent in six cases [25]. Thus, a major unresolved issue is the localization of parvoviral nucleic acid and protein within kidney tissue from individuals with parvovirus B19 infection; it is unclear whether this is due to methodologic or biologic differences or to inclusion of subjects lacking parvoviral infection or at different stages of glomerular disease evolution [26].…”

mentioning

confidence: 99%

Viruses and collapsing glomerulopathy: a brief critical review: Table 1.

Chandra

Kopp

2013

Clin Kidney J

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BackgroundCollapsing glomerulopathy may occur in an idiopathic (primary) form and in association with a wide spectrum of infectious and inflammatory conditions and medications. The association of collapsing glomerulopathy with human immunodeficiency virus (HIV)-1 infection is well established; less certain is the association with other viral infections.MethodsWe searched PubMed for articles in all languages that addressed glomerulopathies associated with parvovirus B19, cytomegalovirus (CMV), Epstein-Barr virus (EBV), hepatitis C virus (HCV) and simian virus 40 (SV40).ResultsCase reports and small-case series link infection with these common viruses and glomerular injury. The evidence for a pathogenic role is generally stronger for glomerulonephritis than for collapsing glomerulopathy.ConclusionsThe evidence linking collapsing glomerulopathy with CMV is relatively strong but not yet conclusive, while the evidence for a pathogenic role for EBV and parvovirus B19 is weaker.

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confidence: 99%

Viruses and collapsing glomerulopathy: a brief critical review: Table 1.

Chandra

Kopp

2013

Clin Kidney J

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“…Our paediatric patient presented with urine abnormalities indicating nephritis. Notably, the association of parvovirus B19 infection with acute postinfectious glomerulonephritis has been earlier described in previously healthy children [1,7,12] and in children with sickle cell disease . Besides acute nephritic syndrome, clinical characteristics of previous case reports included systemic oedema and hypocomplementaemia [8] .…”

Section: Case Reportmentioning

confidence: 83%

Renal Complications Associated with Human Parvovirus B19 Infection in Early Childhood

C¹,

Herz²,

Vieth³

et al. 2007

Klin Padiatr

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A previously healthy two-year-old girl presented with proteinuria and macroscopic haematuria. Laboratory findings included haemolytic anaemia with thrombocytopenia. Interestingly, continuing reticulocytopenia was noted. Therefore an acute parvovirus B19 infection was suspected, which could be confirmed by serological and molecularbiological evidence. This case report underlines renal complications of parvovirus B19 infection in early childhood including haemolytic-uraemic syndrome (HUS)-like episodes, and potential pathogenetic mechanisms are discussed.

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“…Besides, studies have shown that the incidence of nosocomial infections increases significantly after 20 days of admission, and the general length of hospital stay is preferably controlled within 20 days. [ 3 ] So, minimizing the length of hospital stay and reducing the chance of contact with pathogenic bacteria are both good ways for children with PNS. While, the ratio cannot help us judge the specific details of the antibiotics use.…”

Section: Discussionmentioning

confidence: 99%

An empirical study on the index system of rational drug use in children with primary nephrotic syndrome

et al. 2020

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In the study's early stage, the research group had established an evaluation index system for the rational drug use of primary nephrotic syndrome in children. To assess the feasibility of the established index system, we conducted this empirical study. The cross-sectional study was conducted by using the Hospital Information System to extract some general clinical data of hospitalized children with primary nephrotic syndrome, which included registration number, age, sex, diagnosis and medication, etc. Utilize the SPSS23.0 software and Excel 2016 to descriptively analyze information. 224 hospitalized children with primary nephrotic syndrome who met the inclusion criteria were included, ranging from 18 years old and 10 months to 11 months and 23 days, with an average age of 8.40, plus or minus 4.30 years. 148 males (66.07%) and 76 females (33.93%). The duration of hospitalization was 1–57 days, with an average hospitalization time of 10.59 days. The most common is respiratory infections, such as the bronchopneumonia, the mycoplasma pneumonia, etc. This study had successfully completed the measurement of the evaluation index system for the rational drug use of primary nephrotic syndrome in children. All indicators are feasible, but the operability and applicability need further research and improvement.

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Nephrotic syndrome associated with human parvovirus B19 infection

Cited by 34 publications

References 18 publications

Viruses and collapsing glomerulopathy: a brief critical review: Table 1.

Viruses and collapsing glomerulopathy: a brief critical review: Table 1.

Renal Complications Associated with Human Parvovirus B19 Infection in Early Childhood

An empirical study on the index system of rational drug use in children with primary nephrotic syndrome

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